Role of tachykinin receptors and melatonin in oxitocin secretion from isolated rat hypothalmo-neurohypophysial system.

Juszczak M, Furykiewicz-Nykiś K, Stempniak B

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Dec 2004Cited by 1 (Europe PMC)

PMID15613740PepBankPUB-15613740

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01LabEndogenous levelEx vivo tissueMechanism
In the isolated rat hypothalamo-neurohypophysial system, the NK-1 receptor agonist [Sar(9),Met(O(2))(11)]-Substance P increased release of the body's own oxytocin.
In plain wordsIn isolated rat brain tissue, an NK-1 receptor activator increased release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
IncreaseOxytocin release with NK-1 agonist
Study
ratn: not reported in source
isolated hypothalamo-neurohypophysial system
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
highly selective NK-1 receptor agonist, i.e., [Sar(9),Met(O(2))(11)]-Substance P, enhances
1 context sentence(design, population, supporting numbers)
Summary · context
Present investigations were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on oxytocin (OT) release from isolated rat hypothalamo-neurohypophysial (H-N) system
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1561374001
02LabEndogenous levelEx vivo tissueMechanism
In the isolated rat hypothalamo-neurohypophysial system, the NK-1 receptor antagonist sendide significantly reduced release of the body's own oxytocin.
In plain wordsIn isolated rat brain tissue, an NK-1 receptor blocker reduced release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
DecreaseOxytocin release with NK-1 antagonist sendide
Study
ratn: not reported in source
isolated hypothalamo-neurohypophysial system
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
the NK-1 receptor antagonist (Tyr(6),D-Phe(7),D-His(9))-Substance P (6-11) - sendide - diminishes significantly OT secretion
1 context sentence(design, population, supporting numbers)
Summary · context
Present investigations were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on oxytocin (OT) release from isolated rat hypothalamo-neurohypophysial (H-N) system
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1561374002
03LabEndogenous levelEx vivo tissueMechanism
In the isolated rat hypothalamo-neurohypophysial system, sendide at 10(-7) M/L antagonized substance P-induced release of the body's own oxytocin.
In plain wordsIn isolated rat brain tissue, sendide blocked the rise in the body's own oxytocin release caused by substance P.
Peptide
Oxytocin
Outcome
DecreaseSubstance P-induced oxytocin release with sendide
Study
ratn: not reported in source
isolated hypothalamo-neurohypophysial system
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
the latter peptide was also found to antagonize the substance P-induced hormone release from isolated rat H-N system, when used at the concentration of 10(-7) M/L.
1 context sentence(design, population, supporting numbers)
Summary · context
Present investigations were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on oxytocin (OT) release from isolated rat hypothalamo-neurohypophysial (H-N) system
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1561374003
04LabEndogenous levelEx vivo tissueMechanism
In the isolated rat hypothalamo-neurohypophysial system, melatonin significantly inhibited basal and substance P-stimulated release of the body's own oxytocin.
In plain wordsIn isolated rat brain tissue, melatonin reduced release of the body's own oxytocin, both at rest and after substance P.
Peptide
Oxytocin
Outcome
DecreaseOxytocin secretion with melatonin
Study
ratn: not reported in source
isolated hypothalamo-neurohypophysial system
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Melatonin significantly inhibited basal and substance P-stimulated OT secretion.
1 context sentence(design, population, supporting numbers)
Summary · context
Present investigations were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on oxytocin (OT) release from isolated rat hypothalamo-neurohypophysial (H-N) system
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1561374004
05LabEndogenous levelEx vivo tissueMechanism
In the isolated rat hypothalamo-neurohypophysial system, neurokinin A and NK-2 receptor agonist and antagonist did not change release of the body's own oxytocin.
In plain wordsIn isolated rat brain tissue, neurokinin A and NK-2 receptor drugs did not change release of the body's own oxytocin.
Peptide
Oxytocin
Outcome
No significant changeOxytocin release with NK-2 ligands and neurokinin A
Study
ratn: not reported in source
isolated hypothalamo-neurohypophysial system
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Neurokinin A and the NK-2 receptor selective agonist (beta-Ala(8))-Neurokinin A (4-10) as well as the NK-2 receptor antagonist (Tyr(5),D-Trp(6,8,9),Lys-NH(2)(10))-Neurokinin A (4-10) were essentially inactive in modifying OT release from the rat H-N system in vitro.
1 context sentence(design, population, supporting numbers)
Summary · context
Present investigations were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on oxytocin (OT) release from isolated rat hypothalamo-neurohypophysial (H-N) system
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1561374005

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

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