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Study · Measured the body's own peptide · 2004

2 results

Rapid neurosecretory and cardiovascular response to osmotic stimulation in conscious mice.

Chen H, Morris M, Key MP, Chen Y

Neuroendocrinology14 Dec 2004Cited by 6 (Europe PMC)

PMID15604594 (opens in a new tab)DOI10.1159/000082751 (opens in a new tab)PepBankPUB-15604594
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In conscious mice, vascular injection of hypertonic saline caused a rapid, transient rise in the body's own plasma oxytocin.

    In plain wordsIn conscious mice, a salty injection into the blood quickly and briefly raised the body's own oxytocin in blood.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after vascular hypertonic saline
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Measurements

    Plasma OT baseline
    1.5 pg/ml
    hypertonic saline
    Plasma OT earliest time point
    8.6 pg/ml
    hypertonic saline

    Source sentences

    Summary
    Vascular injection of HS (30 microl, 3.4 M NaCl) caused rapid and transient increases in plasma VP and OT.
    2 context sentences
    Summary · context
    plasma OT increased from 1.5 +/- 0.6 to 8.6 +/- 2.4 pg/ml
    Summary · context
    Hypertonic saline (HS) was administered centrally or via the blood stream to conscious mice during measurement of blood pressure (BP), heart rate (HR) and plasma vasopressin (VP) and oxytocin (OT).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In conscious mice, intracerebroventricular hypertonic saline did not change the body's own plasma oxytocin, while it raised plasma vasopressin.

    In plain wordsIn conscious mice, a salty injection into the brain ventricles did not change the body's own oxytocin in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin after intracerebroventricular hypertonic saline
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    ICV osmotic stimulation produced a rapid and sustained increase in plasma VP, with no change in OT.
    1 context sentence
    Summary · context
    Hypertonic saline (HS) was administered centrally or via the blood stream to conscious mice during measurement of blood pressure (BP), heart rate (HR) and plasma vasopressin (VP) and oxytocin (OT).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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