Postprandial changes in plasma GH and insulin concentrations, and responses to stimulation with GH-releasing hormone (GHRH) and GHRP-6 in calves around weaning.

Katoh K, Furukawa G, Kitade K, Katsumata N, Kobayashi Y, Obara Y

The Journal of endocrinology1 Dec 2004Cited by 17 (Europe PMC)

PMID15590976DOI10.1677/joe.1.05898PepBankPUB-15590976

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In 3-week-old calves, venous GHRP‑6 significantly increased plasma GH.
In plain wordsIn young calves, GHRP‑6 raised growth hormone in the blood.
Peptide
GHRP-6
Outcome
IncreasePlasma GH after GHRP-6 in 3-week-old calves
Study
calfn: not reported in source
3-week-old milk-fed calves
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.5 microg/kg · venous injectionAs given in this study (calf).
Source sentences
Summary
The venous injection of either GHRH (0.25 microg/kg) or GHRP-6 (2.5 microg/kg) significantly increased plasma GH concentrations in both 3- and 12-week-old animals, but GH AUC was significantly greater in 3-week-old than in 12-week-old animals.
1 context sentence(design, population, supporting numbers)
Summary · context
Changes in plasma concentrations of GH and insulin in response to feeding and stimulation with GH-releasing hormone (GHRH) or GH-releasing peptide (GHRP-6, a ligand for endogenous GH secretagogue receptors) were compared between 3-week-old (milk-fed) and 12-week-old (concentrate and hay-fed) calves.
Report a problemFND-1559097601
02AnimalAnimal study (in vivo)Efficacy outcome
In 12-week-old calves, venous GHRP‑6 significantly increased plasma GH.
In plain wordsIn older calves, GHRP‑6 raised growth hormone in the blood.
Peptide
GHRP-6
Outcome
IncreasePlasma GH after GHRP-6 in 12-week-old calves
Study
calfn: not reported in source
12-week-old calves
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.5 microg/kg · venous injectionAs given in this study (calf).
Source sentences
Summary
The venous injection of either GHRH (0.25 microg/kg) or GHRP-6 (2.5 microg/kg) significantly increased plasma GH concentrations in both 3- and 12-week-old animals, but GH AUC was significantly greater in 3-week-old than in 12-week-old animals.
1 context sentence(design, population, supporting numbers)
Summary · context
Changes in plasma concentrations of GH and insulin in response to feeding and stimulation with GH-releasing hormone (GHRH) or GH-releasing peptide (GHRP-6, a ligand for endogenous GH secretagogue receptors) were compared between 3-week-old (milk-fed) and 12-week-old (concentrate and hay-fed) calves.
Report a problemFND-1559097602
03AnimalAnimal study (in vivo)Efficacy outcome
In calves, the GH area under the curve after GHRP‑6 was significantly greater in 3-week-old than in 12-week-old animals.
In plain wordsIn calves, the growth hormone rise after GHRP‑6 was larger in 3-week-old animals than in 12-week-old animals.
Peptide
GHRP-6
Outcome
IncreaseGH AUC after GHRP-6, 3-week versus 12-week-old
Study
calfn: not reported in source
3- and 12-week-old calves
Comparator
12-week-old calves
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.5 microg/kg · venous injectionAs given in this study (calf).
Source sentences
Summary
The venous injection of either GHRH (0.25 microg/kg) or GHRP-6 (2.5 microg/kg) significantly increased plasma GH concentrations in both 3- and 12-week-old animals, but GH AUC was significantly greater in 3-week-old than in 12-week-old animals.
1 context sentence(design, population, supporting numbers)
Summary · context
Changes in plasma concentrations of GH and insulin in response to feeding and stimulation with GH-releasing hormone (GHRH) or GH-releasing peptide (GHRP-6, a ligand for endogenous GH secretagogue receptors) were compared between 3-week-old (milk-fed) and 12-week-old (concentrate and hay-fed) calves.
Report a problemFND-1559097603
04AnimalAnimal study (in vivo)Efficacy outcome
In 12-week-old calves, GHRP‑6 transiently and significantly increased plasma insulin.
In plain wordsIn older calves, GHRP‑6 briefly raised insulin in the blood.
Peptide
GHRP-6
Outcome
IncreasePlasma insulin after GHRP-6 in 12-week-old calves
Study
calfn: not reported in source
12-week-old calves
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
2.5 microg/kg · venous injectionAs given in this study (calf).
Source sentences
Summary
Insulin concentration was transiently but significantly increased by the injection of GHRP-6 only in 12-week-old animals, the AUC being greater in 12-week-old than 3-week-old animals.
1 context sentence(design, population, supporting numbers)
Summary · context
Changes in plasma concentrations of GH and insulin in response to feeding and stimulation with GH-releasing hormone (GHRH) or GH-releasing peptide (GHRP-6, a ligand for endogenous GH secretagogue receptors) were compared between 3-week-old (milk-fed) and 12-week-old (concentrate and hay-fed) calves.
Report a problemFND-1559097604
05AnimalAnimal study (in vivo)Efficacy outcome
In 3-week-old calves, GHRP‑6 did not significantly increase plasma insulin.
In plain wordsIn young calves, GHRP‑6 did not clearly change insulin in the blood.
Peptide
GHRP-6
Outcome
No significant changePlasma insulin after GHRP-6 in 3-week-old calves
Study
calfn: not reported in source
3-week-old milk-fed calves
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
2.5 microg/kg · venous injectionAs given in this study (calf).
Source sentences
Summary
Insulin concentration was transiently but significantly increased by the injection of GHRP-6 only in 12-week-old animals, the AUC being greater in 12-week-old than 3-week-old animals.
1 context sentence(design, population, supporting numbers)
Summary · context
Changes in plasma concentrations of GH and insulin in response to feeding and stimulation with GH-releasing hormone (GHRH) or GH-releasing peptide (GHRP-6, a ligand for endogenous GH secretagogue receptors) were compared between 3-week-old (milk-fed) and 12-week-old (concentrate and hay-fed) calves.
Report a problemFND-1559097605
06AnimalAnimal study (in vivo)Efficacy outcome
In calves, the insulin area under the curve after GHRP‑6 was greater in 12-week-old than in 3-week-old animals.
In plain wordsIn calves, the insulin rise after GHRP‑6 was larger in 12-week-old animals than in 3-week-old animals.
Peptide
GHRP-6
Outcome
IncreaseInsulin AUC after GHRP-6, 12-week versus 3-week-old
Study
calfn: not reported in source
3- and 12-week-old calves
Comparator
3-week-old calves
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
2.5 microg/kg · venous injectionAs given in this study (calf).
Source sentences
Summary
Insulin concentration was transiently but significantly increased by the injection of GHRP-6 only in 12-week-old animals, the AUC being greater in 12-week-old than 3-week-old animals.
1 context sentence(design, population, supporting numbers)
Summary · context
Changes in plasma concentrations of GH and insulin in response to feeding and stimulation with GH-releasing hormone (GHRH) or GH-releasing peptide (GHRP-6, a ligand for endogenous GH secretagogue receptors) were compared between 3-week-old (milk-fed) and 12-week-old (concentrate and hay-fed) calves.
Report a problemFND-1559097606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

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