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Study · In vitro (cells) · rat · 2004

7 results

Effects of thymulin and GnRH on the release of gonadotropins by in vitro pituitary cells obtained from rats in each day of estrous cycle.

Hinojosa L, García L, Domínguez R, Romano MC, Damián-Matsumura PG, Castillo L, Rosas P

Life sciences1 Dec 2004Cited by 10 (Europe PMC)

PMID15581911 (opens in a new tab)DOI10.1016/j.lfs.2004.07.017 (opens in a new tab)PepBankPUB-15581911
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In rat pituitary cells from diestrus 1, thymulin increased FSH concentration.

    In plain wordsIn cells from rats in diestrus 1, thymulin increased FSH levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseFSH concentration in diestrus 1
    Study

    ratn: not reported in source

    anterior pituitary suspension cultures from adult female rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adding thymulin to pituitary cells from rats in diestrus 1 increased the concentration of FSH; while in cells from rats in estrus, FSH level decreased.
    1 context sentence
    Summary · context
    The effects of thymulin and GnRH on FSH and LH release were studied in suspension cultures of anterior pituitary cells from female adult rats sacrificed on each day of the estrous cycle.
  2. 02LabIn vitro (cells)Activity measurement

    In rat pituitary cells from estrus, thymulin decreased FSH concentration.

    In plain wordsIn cells from rats in estrus, thymulin decreased FSH levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseFSH concentration in estrus
    Study

    ratn: not reported in source

    anterior pituitary suspension cultures from adult female rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adding thymulin to pituitary cells from rats in diestrus 1 increased the concentration of FSH; while in cells from rats in estrus, FSH level decreased.
    1 context sentence
    Summary · context
    The effects of thymulin and GnRH on FSH and LH release were studied in suspension cultures of anterior pituitary cells from female adult rats sacrificed on each day of the estrous cycle.
  3. 03LabIn vitro (cells)Activity measurement

    In rat pituitary cells, thymulin stimulated basal LH concentration during most days of the estrous cycle.

    In plain wordsIn rat cells, thymulin increased basal LH levels during most days of the estrous cycle.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseBasal LH concentration
    Study

    ratn: not reported in source

    anterior pituitary suspension cultures from adult female rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymulin had a stimulatory effect on the basal concentration of LH during most days of the estrous cycle.
    1 context sentence
    Summary · context
    The effects of thymulin and GnRH on FSH and LH release were studied in suspension cultures of anterior pituitary cells from female adult rats sacrificed on each day of the estrous cycle.
  4. 04LabIn vitro (cells)Activity measurement

    In rat pituitary cells from diestrus 1, diestrus 2, or proestrus, thymulin with GnRH lowered FSH versus GnRH alone.

    In plain wordsIn rat cells from diestrus 1, diestrus 2, or proestrus, thymulin with GnRH lowered FSH compared with GnRH alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseFSH concentration with GnRH
    Study

    ratn: not reported in source

    anterior pituitary suspension cultures from adult female rats
    Comparator
    GnRH alone
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared to the GnRH treatment, the simultaneous addition of thymulin and GnRH to cells from rats in diestrus 1, diestrus 2, or proestrus resulted in lower FSH concentrations.
    1 context sentence
    Summary · context
    The effects of thymulin and GnRH on FSH and LH release were studied in suspension cultures of anterior pituitary cells from female adult rats sacrificed on each day of the estrous cycle.
  5. 05LabIn vitro (cells)Activity measurement

    In rat pituitary cells from diestrus 1, thymulin with GnRH lowered LH release versus GnRH alone.

    In plain wordsIn rat cells from diestrus 1, thymulin with GnRH lowered LH release compared with GnRH alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseLH release in diestrus 1 with GnRH
    Study

    ratn: not reported in source

    anterior pituitary suspension cultures from adult female rats
    Comparator
    GnRH alone
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similar results were observed in the LH release by cells from rats in diestrus 1, while in cells from rats in proestrus or estrus, LH concentrations increased.
    2 context sentences
    Summary · context
    Compared to the GnRH treatment, the simultaneous addition of thymulin and GnRH to cells from rats in diestrus 1, diestrus 2, or proestrus resulted in lower FSH concentrations.
    Summary · context
    The effects of thymulin and GnRH on FSH and LH release were studied in suspension cultures of anterior pituitary cells from female adult rats sacrificed on each day of the estrous cycle.
  6. 06LabIn vitro (cells)Activity measurement

    In rat pituitary cells from proestrus or estrus, thymulin with GnRH increased LH concentration versus GnRH alone.

    In plain wordsIn rat cells from proestrus or estrus, thymulin with GnRH increased LH levels compared with GnRH alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseLH concentration in proestrus or estrus with GnRH
    Study

    ratn: not reported in source

    anterior pituitary suspension cultures from adult female rats
    Comparator
    GnRH alone
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similar results were observed in the LH release by cells from rats in diestrus 1, while in cells from rats in proestrus or estrus, LH concentrations increased.
    2 context sentences
    Summary · context
    Compared to the GnRH treatment, the simultaneous addition of thymulin and GnRH to cells from rats in diestrus 1, diestrus 2, or proestrus resulted in lower FSH concentrations.
    Summary · context
    The effects of thymulin and GnRH on FSH and LH release were studied in suspension cultures of anterior pituitary cells from female adult rats sacrificed on each day of the estrous cycle.
  7. 07LabIn vitro (cells)Mechanism

    In rat pituitary cultures, serum progesterone levels were directly proportional to thymulin effects on FSH release.

    In plain wordsIn rat cells, serum progesterone levels were linked to the size of thymulin effects on FSH release.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseProgesterone association with FSH response
    Study

    ratn: not reported in source

    anterior pituitary suspension cultures from adult female rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A directly proportional relation between progesterone serum levels and the effects of thymulin on FSH release was observed.
    1 context sentence
    Summary · context
    The effects of thymulin and GnRH on FSH and LH release were studied in suspension cultures of anterior pituitary cells from female adult rats sacrificed on each day of the estrous cycle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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