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Study · Not a test of the peptide alone · 2004

2 results

Pro-VGF-derived peptides induce penile erection in male rats: possible involvement of oxytocin.

Succu S, Cocco C, Mascia MS, Melis T, Melis MR, Possenti R, Levi A, Ferri GL, Ferri GL, Argiolas A

The European journal of neuroscience1 Dec 2004Cited by 32 (Europe PMC)

PMID15579158 (opens in a new tab)DOI10.1111/j.1460-9568.2004.03781.x (opens in a new tab)PepBankPUB-15579158
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male rats, a vasotocin analogue given into the lateral ventricles reduced penile erection induced by VGF(588-617), but not when injected into the paraventricular nucleus.

    In plain wordsIn male rats, a vasotocin-type compound in the brain ventricles reduced erections caused by a VGF peptide, but not when given into the paraventricular nucleus.

    Peptide
    Oxytocin
    Outcome
    DecreaseVasotocin analogue effect on VGF-induced penile erection
    Study

    ratn: not reported in source

    Comparator
    VGF peptide alone
    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    d(CH2)5Tyr(Me)-Orn8-vasotocin (1 microg) effectively reduced VGF(588-617)-induced penile erection when given into the lateral ventricles but not when injected into the paraventricular nucleus.
    1 context sentence
    Summary · context
    The effect of five peptides derived from the C-terminal portion of rat pro-VGF (VGF(577-617), VGF(588-617), VGF(599-617), VGF(556-576) and VGF(588-597)) on penile erection was studied after injection into the hypothalamic paraventricular nucleus of male rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In the rat paraventricular nucleus, immunostained pro-VGF terminals impinged on parvocellular oxytocinergic neurons.

    In plain wordsIn rats, nerve endings containing a VGF peptide were found touching oxytocin-producing neurons in a brain area linked to erection.

    Peptide
    Oxytocin
    Outcome
    Not applicableVGF terminals contacting paraventricular oxytocinergic neurons
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    Here, many immunostained neuronal terminals impinged on parvocellular oxytocinergic neurons.
    1 context sentence
    Summary · context
    The effect of five peptides derived from the C-terminal portion of rat pro-VGF (VGF(577-617), VGF(588-617), VGF(599-617), VGF(556-576) and VGF(588-597)) on penile erection was studied after injection into the hypothalamic paraventricular nucleus of male rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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