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Study · Animal study (in vivo) · rat · 2004

4 results

Regulation of ghrelin gene expression in stomach and feeding response to a ghrelin analogue in two strains of rats.

Liu X, York DA, Bray GA

Peptides1 Dec 2004Cited by 18 (Europe PMC)

PMID15572207 (opens in a new tab)DOI10.1016/j.peptides.2004.08.020 (opens in a new tab)PepBankPUB-15572207
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In satiated S5B rats, GHRP‑2 stimulated intake of the low-fat diet in a dose-dependent manner.

    In plain wordsIn satiated S5B rats, GHRP‑2 made the rats eat more low-fat food, with larger doses giving larger effects.

    Peptide
    GHRP-2
    Outcome
    IncreaseLow-fat diet intake in satiated S5B rats
    Study

    ratn: not reported in source

    Osborne-Mendel and S5B/P1 rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    10, 30 and 90 nmol · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In satiated S5B rats, GHRP-2 stimulated intake of the LF diet in a dose dependent manner
    2 context sentences
    Summary · context
    OM and S5B rats were adapted to a choice of high fat (HF) and low fat (LF) diet for 2 weeks.
    Summary · context
    GHRP-2, an analogue of ghrelin, was injected intraperitoneally into satiated and 24 h fasted rats at doses of 10, 30 and 90 nmol.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In satiated S5B rats, GHRP‑2 did not affect intake of the high-fat diet.

    In plain wordsIn satiated S5B rats, GHRP‑2 did not change how much high-fat food the rats ate.

    Peptide
    GHRP-2
    Outcome
    No significant changeHigh-fat diet intake in satiated S5B rats
    Study

    ratn: not reported in source

    Osborne-Mendel and S5B/P1 rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    10, 30 and 90 nmol · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In satiated S5B rats, GHRP-2 stimulated intake of the LF diet in a dose dependent manner but did not affect the intake of the HF diet.
    2 context sentences
    Summary · context
    OM and S5B rats were adapted to a choice of high fat (HF) and low fat (LF) diet for 2 weeks.
    Summary · context
    GHRP-2, an analogue of ghrelin, was injected intraperitoneally into satiated and 24 h fasted rats at doses of 10, 30 and 90 nmol.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In satiated Osborne-Mendel rats, 90 nmol of GHRP‑2 stimulated intake of the high-fat diet.

    In plain wordsIn satiated Osborne-Mendel rats, a 90 nmol dose of GHRP‑2 made the rats eat more high-fat food.

    Peptide
    GHRP-2
    Outcome
    IncreaseHigh-fat diet intake in satiated OM rats
    Study

    ratn: not reported in source

    Osborne-Mendel and S5B/P1 rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    90 nmol · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In satiated OM rats, 90 nmol of GHRP-2 stimulated HF intake.
    2 context sentences
    Summary · context
    OM and S5B rats were adapted to a choice of high fat (HF) and low fat (LF) diet for 2 weeks.
    Summary · context
    GHRP-2, an analogue of ghrelin, was injected intraperitoneally into satiated and 24 h fasted rats at doses of 10, 30 and 90 nmol.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In fasted Osborne-Mendel and S5B rats, GHRP‑2 did not increase intake of either the high-fat or the low-fat diet.

    In plain wordsIn fasted rats of both strains, GHRP‑2 did not make the rats eat more high-fat or low-fat food.

    Peptide
    GHRP-2
    Outcome
    No significant changeFood intake in fasted OM and S5B rats
    Study

    ratn: not reported in source

    Osborne-Mendel and S5B/P1 rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    10, 30 and 90 nmol · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In contrast, neither fasted OM nor S5B rats increased the intake of either HF or LF diet in response to GHRP-2.
    2 context sentences
    Summary · context
    OM and S5B rats were adapted to a choice of high fat (HF) and low fat (LF) diet for 2 weeks.
    Summary · context
    GHRP-2, an analogue of ghrelin, was injected intraperitoneally into satiated and 24 h fasted rats at doses of 10, 30 and 90 nmol.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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