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Study · Measured the body's own peptide · 2005

3 results

Co-expression patterns of the neuropeptides vasoactive intestinal peptide and cholecystokinin with the transduction molecules alpha-gustducin and T1R2 in rat taste receptor cells.

Shen T, Kaya N, Zhao FL, Lu SG, Cao Y, Herness S

Neuroscience1 Jan 2005Cited by 68 (Europe PMC)

PMID15561439 (opens in a new tab)DOI10.1016/j.neuroscience.2004.09.017 (opens in a new tab)PepBankPUB-15561439
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rat posterior taste buds, 60% of VIP-expressing taste receptor cells also expressed alpha-gustducin mRNA.

    In plain wordsIn rats, most taste cells that make the body's own VIP also make gustducin, a taste signalling protein.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-expressing taste cells that co-express alpha-gustducin mRNA
    Study

    ratn: not reported in source

    taste buds of the posterior rat tongue
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Measurements

    Co-expression with alpha-gustducin mRNA
    60%
    VIP-expressing taste receptor cells

    Source sentences

    Summary
    A majority of VIP-expressing taste receptor cells co-expressed alpha-gustducin mRNA (60%) whereas only 19% of these cells co-expressed T1R2 mRNA.
    1 context sentence
    Summary · context
    Double labeling experiments were performed on taste buds of the posterior rat tongue combining immunocytochemistry for peptide expression and in situ hybridization experiments for either gustducin or T1R2 expression.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rat posterior taste buds, 19% of VIP-expressing taste receptor cells also expressed T1R2 mRNA.

    In plain wordsIn rats, few taste cells that make the body's own VIP also make T1R2, a sweet taste receptor.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-expressing taste cells that co-express T1R2 mRNA
    Study

    ratn: not reported in source

    taste buds of the posterior rat tongue
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Measurements

    Co-expression with T1R2 mRNA
    19%
    VIP-expressing taste receptor cells

    Source sentences

    Summary
    A majority of VIP-expressing taste receptor cells co-expressed alpha-gustducin mRNA (60%) whereas only 19% of these cells co-expressed T1R2 mRNA.
    1 context sentence
    Summary · context
    Double labeling experiments were performed on taste buds of the posterior rat tongue combining immunocytochemistry for peptide expression and in situ hybridization experiments for either gustducin or T1R2 expression.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rat posterior taste receptor cells, RT-PCR confirmed expression of VIP.

    In plain wordsIn rats, a lab test confirmed that posterior taste cells make the body's own VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP expression in posterior taste receptor cells (RT-PCR)
    Study

    ratn: not reported in source

    taste buds of the posterior rat tongue
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Additionally, vasoactive intestinal peptide (VIP)-expression in posterior taste receptor cells was confirmed using the technique of RT-PCR.
    1 context sentence
    Summary · context
    Double labeling experiments were performed on taste buds of the posterior rat tongue combining immunocytochemistry for peptide expression and in situ hybridization experiments for either gustducin or T1R2 expression.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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