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Study · Randomized controlled trial · n = 53 · 2004

15 results

Intelligence and psychosocial functioning during long-term growth hormone therapy in children born small for gestational age.

van Pareren YK, Duivenvoorden HJ, Slijper FS, Koot HM, Hokken-Koelega AC

The Journal of clinical endocrinology and metabolism1 Nov 2004Cited by 83 (Europe PMC)

PMID15531473 (opens in a new tab)DOI10.1210/jc.2003-031187 (opens in a new tab)PepBankPUB-15531473
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. 15 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In children born SGA, the study found no significant differences between the two GH dosage groups.

    In plain wordsIn children born SGA, the study found no significant differences between the two growth hormone dosage groups.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeDose group differences
    Study

    n: not reported in source

    Comparator
    other GH dosage group
    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Source sentences

    Summary
    No significant differences between the two GH dosage groups were found.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  2. 02HumanNon-randomized trialEfficacy outcome

    In short children born SGA, 48 of 53 children (91%) had normal height in 2001 during long-term GH treatment.

    In plain wordsIn short children born SGA, 48 of 53 children had normal height during long-term growth hormone treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableNormal height in 2001
    Study

    n = 53

    Outcome group
    Linear growth · Musculoskeletal
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Measurements

    Children with normal height in 2001
    91%
    48 of 53 participating children, 2001
    Children with normal height in 2001
    48 children
    of 53 participating children, 2001

    Source sentences

    Summary
    In 2001, 48 (91%) of the 53 children participating in this study had reached a normal height.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  3. 03HumanNon-randomized trialEfficacy outcome

    In short children born SGA, 96% of both GH groups gained at least 1 height SD score after 2 yr.

    In plain wordsIn short children born SGA, 96% of both growth hormone groups gained at least 1 height SD score after 2 yr.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseHeight gain responder
    Study

    n: not reported in source

    Outcome group
    Linear growth · Musculoskeletal
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · 2 yrAs given in this study (human).

    Measurements

    Proportion with height gain SDS >= 1 SD from start
    96%
    both GH groups, after 2 yr

    Source sentences

    Summary
    After 2 yr of GH treatment, 96% of both GH groups showed a height gain sd score of 1 sd from the start of treatment or more, resulting in a normal height (i.e. height >/= -2.0 sd for age and sex) in 70% of the children.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  4. 04HumanNon-randomized trialEfficacy outcome

    In short children born SGA, 70% reached normal height after 2 yr of GH treatment.

    In plain wordsIn short children born SGA, 70% reached normal height after 2 yr of growth hormone treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableNormal height after two years
    Study

    n: not reported in source

    Outcome group
    Linear growth · Musculoskeletal
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · 2 yrAs given in this study (human).

    Measurements

    Children with normal height (height >= -2.0 SD) after 2 yr
    70%
    GH-treated children, 2 yr

    Source sentences

    Summary
    After 2 yr of GH treatment, 96% of both GH groups showed a height gain sd score of 1 sd from the start of treatment or more, resulting in a normal height (i.e. height >/= -2.0 sd for age and sex) in 70% of the children.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  5. 05HumanNon-randomized trialEfficacy outcome

    In children born SGA, Block-design scores increased during GH treatment (P < 0.001), reaching scores comparable to Dutch peers in 2001.

    In plain wordsIn children born SGA, Block-design scores increased during growth hormone treatment and became comparable to Dutch peers.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseBlock-design score
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Measurements

    P value
    < 0.001 P value
    Block-design s-score increase over time
    P value
    < 0.001 P value
    Block-design s-score lower than Dutch peers at start

    Source sentences

    Summary
    Block-design s-score and the estimated total IQ significantly increased (P < 0.001 and P < 0.001, respectively) from scores significantly lower than Dutch peers at start (P < 0.001 and P < 0.001, respectively) to comparable scores in 2001.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  6. 06HumanNon-randomized trialEfficacy outcome

    In children born SGA, estimated total IQ increased during GH treatment (P < 0.001), reaching scores comparable to Dutch peers in 2001.

    In plain wordsIn children born SGA, estimated IQ increased during growth hormone treatment and became comparable to Dutch peers.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseEstimated total IQ
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Measurements

    P value
    < 0.001 P value
    estimated total IQ increase over time
    P value
    < 0.001 P value
    estimated total IQ lower than Dutch peers at start

    Source sentences

    Summary
    Block-design s-score and the estimated total IQ significantly increased (P < 0.001 and P < 0.001, respectively) from scores significantly lower than Dutch peers at start (P < 0.001 and P < 0.001, respectively) to comparable scores in 2001.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  7. 07HumanNon-randomized trialEfficacy outcome

    In children born SGA, Vocabulary scores did not increase significantly during GH treatment.

    In plain wordsIn children born SGA, Vocabulary scores did not increase significantly during growth hormone treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeVocabulary score
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Source sentences

    Summary
    The increase over time for the Vocabulary s-score was not significant.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  8. 08HumanNon-randomized trialEfficacy outcome

    In children born SGA, Externalizing Behavior SD scores improved during GH treatment (P < 0.01), becoming comparable to Dutch peers.

    In plain wordsIn children born SGA, externalizing behavior scores improved during growth hormone treatment and became comparable to Dutch peers.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseExternalizing behavior
    Study

    n: not reported in source

    Outcome group
    Locomotor and behavioral activity · Mental health and mood
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Measurements

    P value
    < 0.01 P value
    Externalizing Behavior sd score improvement during GH therapy

    Source sentences

    Summary
    Internalizing Behavior sd scores remained comparable to Dutch peers, whereas Externalizing Behavior sd scores and Total Problem Behavior sd scores improved significantly during GH therapy (P < 0.01 and P < 0.05, respectively) to scores comparable to Dutch peers.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  9. 09HumanNon-randomized trialEfficacy outcome

    In children born SGA, Total Problem Behavior SD scores improved during GH treatment (P < 0.05), becoming comparable to Dutch peers.

    In plain wordsIn children born SGA, total problem behavior scores improved during growth hormone treatment and became comparable to Dutch peers.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseTotal problem behavior
    Study

    n: not reported in source

    Outcome group
    Locomotor and behavioral activity · Mental health and mood
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Measurements

    P value
    < 0.05 P value
    Total Problem Behavior sd score improvement during GH therapy

    Source sentences

    Summary
    Internalizing Behavior sd scores remained comparable to Dutch peers, whereas Externalizing Behavior sd scores and Total Problem Behavior sd scores improved significantly during GH therapy (P < 0.01 and P < 0.05, respectively) to scores comparable to Dutch peers.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  10. 10HumanNon-randomized trialEfficacy outcome

    In children born SGA, self-perception SD scores improved during GH treatment until 2001 (P < 0.001).

    In plain wordsIn children born SGA, self-perception scores improved from the start of growth hormone treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSelf-perception change
    Study

    n: not reported in source

    Outcome group
    Quality of life · Mental health and mood
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Measurements

    P value
    < 0.001 P value
    self-perception sd score improvement from start of GH treatment until 2001

    Source sentences

    Summary
    Self-perception sd scores improved from start of GH treatment until 2001 (P < 0.001) to scores significantly higher than Dutch peers (P < 0.05).
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  11. 11HumanObservational studyEfficacy outcome

    In children born SGA given GH, Internalizing Behavior SD scores remained comparable to Dutch peers.

    In plain wordsIn children born SGA given growth hormone, internalizing behavior scores remained comparable to Dutch peers.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeInternalizing behavior
    Study

    n: not reported in source

    Comparator
    Dutch peers
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Source sentences

    Summary
    Internalizing Behavior sd scores remained comparable to Dutch peers, whereas Externalizing Behavior sd scores and Total Problem Behavior sd scores improved significantly during GH therapy (P < 0.01 and P < 0.05, respectively) to scores comparable to Dutch peers.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  12. 12HumanObservational studyEfficacy outcome

    In children born SGA given GH, self-perception SD scores became higher than Dutch peers (P < 0.05).

    In plain wordsIn children born SGA given growth hormone, self-perception scores became higher than Dutch peers.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSelf-perception peer comparison
    Study

    n: not reported in source

    Comparator
    Dutch peers
    Outcome group
    Quality of life · Mental health and mood
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Measurements

    P value
    < 0.05 P value
    self-perception sd score higher than Dutch peers

    Source sentences

    Summary
    Self-perception sd scores improved from start of GH treatment until 2001 (P < 0.001) to scores significantly higher than Dutch peers (P < 0.05).
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  13. 13HumanObservational studyOther

    In GH-treated children born SGA, improvement in Externalizing Behavior scores was linked to height SD score change (P < 0.05).

    In plain wordsIn children born SGA given growth hormone, improved externalizing behavior was linked to height change.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableExternalizing behavior and height association
    Study

    n: not reported in source

    Outcome group
    Locomotor and behavioral activity · Mental health and mood
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Measurements

    P value
    < 0.05 P value
    Externalizing Behavior improvement related to change in height sd score

    Source sentences

    Summary
    Improvement in Externalizing and Total Problem Behavior sd scores over time was significantly related to change in height sd score (P < 0.05 and P < 0.01, respectively),
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  14. 14HumanObservational studyOther

    In GH-treated children born SGA, improvement in Total Problem Behavior scores was linked to height SD score change (P < 0.01).

    In plain wordsIn children born SGA given growth hormone, improved total problem behavior was linked to height change.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableTotal problem behavior and height association
    Study

    n: not reported in source

    Outcome group
    Locomotor and behavioral activity · Mental health and mood
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Measurements

    P value
    < 0.01 P value
    Total Problem Behavior improvement related to change in height sd score

    Source sentences

    Summary
    Improvement in Externalizing and Total Problem Behavior sd scores over time was significantly related to change in height sd score (P < 0.05 and P < 0.01, respectively),
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).
  15. 15HumanObservational studyOther

    In GH-treated children born SGA, Vocabulary, Block-design, Internalizing, and total self-perception scores were not related to height SD score changes.

    In plain wordsIn children born SGA given growth hormone, the other listed cognitive, behavior, and self-perception scores were not linked to height changes.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableOther scores and height association
    Study

    n: not reported in source

    Outcome group
    Overall treatment effect · Mental health and mood
    Studied dose
    1 or 2 mg GH/m(2) body surface.d · mean 8.0 (0.2) yrAs given in this study (human).

    Source sentences

    Summary
    whereas scores over time for Vocabulary, Block-design, Internalizing, or total Harter Self-Perception score were not related to change in height sd scores.
    2 context sentences
    Summary · context
    We show the longitudinal results of a randomized, double-blind, GH-dose response study initiated in 1991 to follow growth, intelligence quotient (IQ), and psychosocial functioning in SGA children during long-term GH treatment.
    Summary · context
    Patients were assigned to one of two treatment groups (1 or 2 mg GH/m(2) body surface.d, or approximately 0.035 or 0.07 mg/kg.d).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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