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Study · Not a test of the peptide alone · 2004

8 results

[Antiviral activity of human recombinant gamma-interferon and recombinant hybrid protein of tumor necrosis factor-alpha-thymosin-alpha1 on models of herpes-virus and cytomegalovirus infection in vitro].

Barinskiĭ IF, Alimbarova LM, Platonova AA, Shmelev VA

Voprosy virusologii1 Sept 2004

PMID15529863 (opens in a new tab)PepBankPUB-15529863
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In human embryo fibroblast cultures, IFN-gamma and the TNF-alpha-thymosin-alpha1 hybrid protein (TNF-T) had no virucidal action.

    In plain wordsIn cells, interferon-gamma and the TNF-T hybrid protein did not kill virus particles directly.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeVirucidal action
    Study

    humann: not reported in source

    Human embryo fibroblast cell cultures
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    The drugs have no viricidal action.
    1 context sentence
    Summary · context
    The conducted studies showed a certain efficiency of gene-engineering preparation of IFN-gamma and TNF-T in virus infections caused by herpes simplex virus 2 (HSV-2) and cytomegalovirus (CMV) in cell cultures of human embryo fibroblast (HEF).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In human embryo fibroblast cultures infected with HSV-2 or CMV, IFN-gamma was more effective than the TNF-T hybrid protein under the treatment scheme.

    In plain wordsIn cells infected with herpes virus or cytomegalovirus, interferon-gamma worked better than the TNF-T hybrid protein when used as treatment.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAntiviral efficacy of TNF-T relative to IFN-gamma
    Study

    humann: not reported in source

    Human embryo fibroblast cell cultures
    Comparator
    IFN-gamma
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    IFN-gamma, when used according to the treatment scheme in vitro, proved to be more effective versus TMF-T both in HSV-2 and in CMV.
    1 context sentence
    Summary · context
    The conducted studies showed a certain efficiency of gene-engineering preparation of IFN-gamma and TNF-T in virus infections caused by herpes simplex virus 2 (HSV-2) and cytomegalovirus (CMV) in cell cultures of human embryo fibroblast (HEF).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In human embryo fibroblast cultures with cytomegalovirus, TNF-T was effective at dilutions of 1:500 and lower, and in 0.1 multiple infection.

    In plain wordsIn cells infected with cytomegalovirus, the TNF-T hybrid protein reduced virus growth at dilutions of 1:500 and lower.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseCMV inhibition by TNF-T (treatment scheme)
    Study

    humann: not reported in source

    Human embryo fibroblast cell cultures
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    whereas TNF-T was effective within the range of 1:500 and lower as well as in 0.1 multiple infection
    1 context sentence
    Summary · context
    The conducted studies showed a certain efficiency of gene-engineering preparation of IFN-gamma and TNF-T in virus infections caused by herpes simplex virus 2 (HSV-2) and cytomegalovirus (CMV) in cell cultures of human embryo fibroblast (HEF).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  4. 04LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In human embryo fibroblast cultures, when used for prevention, TNF-T was effective against HSV-2 in the 1:50 dilution range.

    In plain wordsIn cells, the TNF-T hybrid protein used before infection reduced herpes simplex virus 2 growth at a 1:50 dilution.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseHSV-2 inhibition by TNF-T (prevention scheme)
    Study

    humann: not reported in source

    Human embryo fibroblast cell cultures
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    whereas TNF-T was effective in the range of 1:50
    1 context sentence
    Summary · context
    The conducted studies showed a certain efficiency of gene-engineering preparation of IFN-gamma and TNF-T in virus infections caused by herpes simplex virus 2 (HSV-2) and cytomegalovirus (CMV) in cell cultures of human embryo fibroblast (HEF).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  5. 05LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In human embryo fibroblast cultures, IFN-gamma and TNF-T gave a significantly higher antiviral effect when used for prevention than when used for treatment.

    In plain wordsIn cells, interferon-gamma and the TNF-T hybrid protein worked better when added before infection than when added after.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseEffect of preventive use compared with treatment use
    Study

    humann: not reported in source

    Human embryo fibroblast cell cultures
    Comparator
    Treatment scheme
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    A significantly higher effect was ensured when the drugs were used for prevention.
    1 context sentence
    Summary · context
    The conducted studies showed a certain efficiency of gene-engineering preparation of IFN-gamma and TNF-T in virus infections caused by herpes simplex virus 2 (HSV-2) and cytomegalovirus (CMV) in cell cultures of human embryo fibroblast (HEF).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  6. 06LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In human embryo fibroblast cultures, TNF-T added 24 hours before HSV-2 infection gave its highest inhibition, 1.0 Ig at a 1:50 dilution.

    In plain wordsIn cells, the TNF-T hybrid protein worked best against herpes simplex virus 2 when added 24 hours before infection.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseHighest HSV-2 inhibition (TNF-T, 24 h before infection)
    Study

    humann: not reported in source

    Human embryo fibroblast cell cultures
    Outcome group
    Antiviral activity · Infection

    Measurements

    Inhibition
    1 Ig
    TNF-T, HSV-2, 24 h before infection, dilution 1:50

    Source sentences

    Summary
    The highest inhibition values were registered for HSV-2, when it was used 24 hours before infection (IFN-gamma--2.25 Ig, dilution range of 1:50; TNF-2--1.0 Ig, dilution range of 1:50).
    1 context sentence
    Summary · context
    The conducted studies showed a certain efficiency of gene-engineering preparation of IFN-gamma and TNF-T in virus infections caused by herpes simplex virus 2 (HSV-2) and cytomegalovirus (CMV) in cell cultures of human embryo fibroblast (HEF).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  7. 07LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Mechanism

    In human embryo fibroblast cultures, IFN-gamma and TNF-T together acted synergistically on different stages of virus reproduction.

    In plain wordsIn cells, interferon-gamma and the TNF-T hybrid protein together acted on different stages of virus growth.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableSynergy of IFN-gamma and TNF-T
    Study

    humann: not reported in source

    Human embryo fibroblast cell cultures
    Outcome group
    Receptor activity and mechanism · Infection

    Source sentences

    Summary
    IFN-gamma and TNF-2 exert a synergic action on different stages of virus reproduction.
    1 context sentence
    Summary · context
    The conducted studies showed a certain efficiency of gene-engineering preparation of IFN-gamma and TNF-T in virus infections caused by herpes simplex virus 2 (HSV-2) and cytomegalovirus (CMV) in cell cultures of human embryo fibroblast (HEF).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  8. 08LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In human embryo fibroblast cultures with cytomegalovirus, IFN-gamma and TNF-T given 4 hours before infection gave an additive antiviral effect.

    In plain wordsIn cells infected with cytomegalovirus, interferon-gamma and the TNF-T hybrid protein together added up their effects when given before infection.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAdditive effect of IFN-gamma and TNF-T against CMV
    Study

    humann: not reported in source

    Human embryo fibroblast cell cultures
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    A reliable additive effect was ensured in prevention made 4 hour before infection by IFN-gamma and TNF-T only in experimental CMV infection.
    1 context sentence
    Summary · context
    The conducted studies showed a certain efficiency of gene-engineering preparation of IFN-gamma and TNF-T in virus infections caused by herpes simplex virus 2 (HSV-2) and cytomegalovirus (CMV) in cell cultures of human embryo fibroblast (HEF).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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