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Study · Animal study (in vivo) · mouse · 2004

6 results

[Application of immunomodulators for correction of changes in the immune system in conditions of experimental hypothyroidism].

Zamotaieva HA, Sydorenko DS, Stepura NM, Zakharchenko TF, Hoĭdash MM, Skvyrs'ka LM

Klinichna khirurhiia1 Jul 2004

PMID15495616 (opens in a new tab)PepBankPUB-15495616
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In thyroidectomized mice, thymogen partly restored reduced thymus endocrine function.

    In plain wordsIn mice after thyroid removal, thymogen partly restored thymus endocrine function.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseThymus endocrine function
    Study

    Micen: not reported in source

    Thyroidectomy-induced hypothyroidism
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · InjectionAs given in this study (Mice).

    Source sentences

    Summary
    The restorational therapy conduction using thyroxin, injections of thymogen or polyoxydonium removed the above mentioned changes only in part.
    2 context sentences
    Summary · context
    In hypothyrosis there was observed the trustworthy lowering of the thymus endocrine function, interleukine-2 activity, cytotoxic activity in the physiological cell-killers, the leukocytes proliferating ability and increase of the blood content of circulating immune complexes as well.
    Summary · context
    Changes of the immune system state were investigated in mice after performance of thyroidectomy under the influence of hormonal therapy using thyroxin and immunotropic preparations thymogen and polyoxydonium.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In thyroidectomized mice, thymogen partly restored reduced interleukin-2 activity.

    In plain wordsIn mice after thyroid removal, thymogen partly restored interleukin-2 activity.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseInterleukin-2 activity
    Study

    Micen: not reported in source

    Thyroidectomy-induced hypothyroidism
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · InjectionAs given in this study (Mice).

    Source sentences

    Summary
    The restorational therapy conduction using thyroxin, injections of thymogen or polyoxydonium removed the above mentioned changes only in part.
    2 context sentences
    Summary · context
    In hypothyrosis there was observed the trustworthy lowering of the thymus endocrine function, interleukine-2 activity, cytotoxic activity in the physiological cell-killers, the leukocytes proliferating ability and increase of the blood content of circulating immune complexes as well.
    Summary · context
    Changes of the immune system state were investigated in mice after performance of thyroidectomy under the influence of hormonal therapy using thyroxin and immunotropic preparations thymogen and polyoxydonium.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In thyroidectomized mice, thymogen partly restored reduced natural killer cell cytotoxic activity.

    In plain wordsIn mice after thyroid removal, thymogen partly restored natural killer cell activity.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseNatural killer cell cytotoxic activity
    Study

    Micen: not reported in source

    Thyroidectomy-induced hypothyroidism
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · InjectionAs given in this study (Mice).

    Source sentences

    Summary
    The restorational therapy conduction using thyroxin, injections of thymogen or polyoxydonium removed the above mentioned changes only in part.
    2 context sentences
    Summary · context
    In hypothyrosis there was observed the trustworthy lowering of the thymus endocrine function, interleukine-2 activity, cytotoxic activity in the physiological cell-killers, the leukocytes proliferating ability and increase of the blood content of circulating immune complexes as well.
    Summary · context
    Changes of the immune system state were investigated in mice after performance of thyroidectomy under the influence of hormonal therapy using thyroxin and immunotropic preparations thymogen and polyoxydonium.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In thyroidectomized mice, thymogen partly restored reduced leukocyte proliferation.

    In plain wordsIn mice after thyroid removal, thymogen partly restored leukocyte proliferation.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseLeukocyte proliferation
    Study

    Micen: not reported in source

    Thyroidectomy-induced hypothyroidism
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · InjectionAs given in this study (Mice).

    Source sentences

    Summary
    The restorational therapy conduction using thyroxin, injections of thymogen or polyoxydonium removed the above mentioned changes only in part.
    2 context sentences
    Summary · context
    In hypothyrosis there was observed the trustworthy lowering of the thymus endocrine function, interleukine-2 activity, cytotoxic activity in the physiological cell-killers, the leukocytes proliferating ability and increase of the blood content of circulating immune complexes as well.
    Summary · context
    Changes of the immune system state were investigated in mice after performance of thyroidectomy under the influence of hormonal therapy using thyroxin and immunotropic preparations thymogen and polyoxydonium.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In thyroidectomized mice, thymogen partly reduced elevated circulating immune complexes.

    In plain wordsIn mice after thyroid removal, thymogen partly reduced elevated circulating immune complexes.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseCirculating immune complexes
    Study

    Micen: not reported in source

    Thyroidectomy-induced hypothyroidism
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · InjectionAs given in this study (Mice).

    Source sentences

    Summary
    The restorational therapy conduction using thyroxin, injections of thymogen or polyoxydonium removed the above mentioned changes only in part.
    2 context sentences
    Summary · context
    In hypothyrosis there was observed the trustworthy lowering of the thymus endocrine function, interleukine-2 activity, cytotoxic activity in the physiological cell-killers, the leukocytes proliferating ability and increase of the blood content of circulating immune complexes as well.
    Summary · context
    Changes of the immune system state were investigated in mice after performance of thyroidectomy under the influence of hormonal therapy using thyroxin and immunotropic preparations thymogen and polyoxydonium.

Studies that did not test the peptide alone1

In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymogen (oglufanide).

  1. 06AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome

    In thyroidectomized mice with compensated hypothyroidism, immunomodulators including thymogen restored immune state.

    In plain wordsIn mice with compensated hypothyroidism, immunomodulators including thymogen restored immune state.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseImmune state restoration with compensated hypothyroidism
    Study

    Micen: not reported in source

    Thyroidectomy-induced hypothyroidism
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The immunomodulators application, under condition of the hypothyrosis compensation occurrence, have had promoted the essential raising of their therapeutic action and secured the immune state restoration after thyroidectomy performance.
    1 context sentence
    Summary · context
    Changes of the immune system state were investigated in mice after performance of thyroidectomy under the influence of hormonal therapy using thyroxin and immunotropic preparations thymogen and polyoxydonium.

    In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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