Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to the brain.

Dufes C, Gaillard F, Uchegbu IF, Schätzlein AG, Olivier JC, Muller JM

International journal of pharmaceutics1 Nov 2004Cited by 44 (Europe PMC)

PMID15488681DOI10.1016/j.ijpharm.2004.07.020PepBankPUB-15488681

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In mice, HPLC showed intact VIP in the brain after injection of VIP-loaded niosomes but not after injection of VIP solution.
In plain wordsIn mice, intact VIP reached the brain when carried in niosomes but not when injected as a plain solution.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableIntact VIP in brain by HPLC
Study
mousen: not reported in source
in vivo
Comparator
VIP solution
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · intravenousAs given in this study (mouse).
Source sentences
Summary
HPLC analysis confirmed the presence of intact VIP in brain after administration of VIP-loaded niosomes, but not after administration of VIP solution.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end, VIP/125I-VIP-loaded glucose-bearing niosomes were intravenously injected to mice.
Report a problemFND-1548868101
02AnimalAnimal study (in vivo)Pharmacokinetics
In mice, VIP in glucose-bearing niosomes gave a significantly higher brain uptake than VIP in control niosomes, up to 86% at 5 min after treatment.
In plain wordsIn mice, VIP in glucose-bearing niosomes reached the brain more than VIP in control niosomes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseBrain uptake of VIP
Study
mousen: not reported in source
in vivo
Comparator
Control niosomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · intravenousAs given in this study (mouse).
Measurements
Increase in brain uptake
≤ 86%
5 min after treatment
Source sentences
Summary
Encapsulation within glucose-bearing niosomes mainly allowed a significantly higher VIP brain uptake compared to control niosomes (up to 86%, 5min after treatment).
1 context sentence(design, population, supporting numbers)
Summary · context
To this end, VIP/125I-VIP-loaded glucose-bearing niosomes were intravenously injected to mice.
Report a problemFND-1548868102
03AnimalAnimal study (in vivo)Pharmacokinetics
In mice, intact VIP from glucose-bearing niosomes was found mainly in the posterior and anterior brain, but was spread evenly after control niosomes.
In plain wordsIn mice, VIP from glucose-bearing niosomes collected in the front and back of the brain; control niosomes spread it evenly.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableRegional brain distribution of intact VIP
Study
mousen: not reported in source
in vivo
Comparator
Control niosomes
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · intravenousAs given in this study (mouse).
Source sentences
Summary
Brain distribution of intact VIP after injection of glucose-bearing niosomes, indicated that radioactivity was preferentially located in the posterior and the anterior parts of the brain, whereas it was homogeneously distributed in the whole brain after the administration of control vesicles.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end, VIP/125I-VIP-loaded glucose-bearing niosomes were intravenously injected to mice.
Report a problemFND-1548868103

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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