Skeletal unloading alleviates the anabolic action of intermittent PTH(1-34) in mouse tibia in association with inhibition of PTH-induced increase in c-fos mRNA in bone marrow cells.

Tanaka S, Sakai A, Tanaka M, Otomo H, Okimoto N, Sakata T, Nakamura T

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research16 Aug 2004Cited by 40 (Europe PMC)

PMID15476581DOI10.1359/jbmr.040808PepBankPUB-15476581

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

01AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In PTH-treated mice, unloading decreased bone volume at the reported endpoint.
In plain wordsIn mice receiving PTH, unloading reduced bone volume compared with loading.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseBone volume
Study
mousen: not reported in source
Tail-suspended male C57BL/6J mice
Comparator
Loaded PTH-treated mice
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
At 15 days of unloading, bone volume decreased in PTH-treated mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty male C57BL/6J mice, 8 weeks of age, were divided into four groups with loading or unloading and administration of PTH (40 microg/kg body weight) or vehicle five times per week.
Summary · context
Mice were killed at 8 or 15 days, and both tibias were obtained.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1547658101
02AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In mice receiving intermittent PTH, unloading accelerated bone resorption.
In plain wordsIn mice receiving PTH, unloading accelerated bone breakdown compared with loading.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone resorption
Study
mousen: not reported in source
Tail-suspended male C57BL/6J mice
Comparator
Loaded PTH-treated mice
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Unloading alleviated the PTH-induced increase of bone formation and accelerated bone resorption, consequently reducing bone mass.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty male C57BL/6J mice, 8 weeks of age, were divided into four groups with loading or unloading and administration of PTH (40 microg/kg body weight) or vehicle five times per week.
Summary · context
Mice were killed at 8 or 15 days, and both tibias were obtained.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1547658102
03AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In mice, unloading depressed the PTH-induced increase in bone formation rate.
In plain wordsIn mice, unloading reduced the PTH-related increase in bone formation compared with loading.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseBone formation rate
Study
mousen: not reported in source
Tail-suspended male C57BL/6J mice
Comparator
Loaded PTH-treated mice
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The increase in the bone formation rate by PTH was depressed, and the osteoclast surface was thoroughly increased.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty male C57BL/6J mice, 8 weeks of age, were divided into four groups with loading or unloading and administration of PTH (40 microg/kg body weight) or vehicle five times per week.
Summary · context
Mice were killed at 8 or 15 days, and both tibias were obtained.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1547658103
04AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In PTH-treated mice, unloading increased osteoclast surface.
In plain wordsIn mice receiving PTH, unloading increased osteoclast surface compared with loading.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteoclast surface
Study
mousen: not reported in source
Tail-suspended male C57BL/6J mice
Comparator
Loaded PTH-treated mice
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The increase in the bone formation rate by PTH was depressed, and the osteoclast surface was thoroughly increased.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty male C57BL/6J mice, 8 weeks of age, were divided into four groups with loading or unloading and administration of PTH (40 microg/kg body weight) or vehicle five times per week.
Summary · context
Mice were killed at 8 or 15 days, and both tibias were obtained.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1547658104
05AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In mice, unloading maintained the PTH-induced increase in alkaline phosphatase-positive CFU-f colonies.
In plain wordsIn mice, unloading preserved the PTH-related increase in bone-forming cell colonies compared with loading.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeAlkaline phosphatase-positive CFU-f colonies
Study
mousen: not reported in source
Tail-suspended male C57BL/6J mice
Comparator
Loaded PTH-treated mice
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The increase in alkaline phosphatase-positive colony-forming units-fibroblastic (CFU-f) colonies induced by PTH was maintained and that of TRACP+ multinucleated cells enhanced.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty male C57BL/6J mice, 8 weeks of age, were divided into four groups with loading or unloading and administration of PTH (40 microg/kg body weight) or vehicle five times per week.
Summary · context
Mice were killed at 8 or 15 days, and both tibias were obtained.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1547658105
06AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In mice, unloading enhanced the PTH-induced increase in TRACP-positive multinucleated cells.
In plain wordsIn mice, unloading enhanced the PTH-related increase in TRACP-positive cells compared with loading.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTRACP-positive multinucleated cells
Study
mousen: not reported in source
Tail-suspended male C57BL/6J mice
Comparator
Loaded PTH-treated mice
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The increase in alkaline phosphatase-positive colony-forming units-fibroblastic (CFU-f) colonies induced by PTH was maintained and that of TRACP+ multinucleated cells enhanced.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty male C57BL/6J mice, 8 weeks of age, were divided into four groups with loading or unloading and administration of PTH (40 microg/kg body weight) or vehicle five times per week.
Summary · context
Mice were killed at 8 or 15 days, and both tibias were obtained.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1547658106
07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In mice, unloading depressed the PTH-induced increase in c-fos mRNA.
In plain wordsIn mice, unloading reduced the PTH-related increase in c-fos mRNA compared with loading.
Peptide
Teriparatide (PTH 1-34)
Outcome
Decreasec-fos mRNA
Study
mousen: not reported in source
Tail-suspended male C57BL/6J mice
Comparator
Loaded PTH-treated mice
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The PTH-induced increase in c-fos mRNA was depressed, but the increases in Osterix and RANKL mRNA were maintained.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty male C57BL/6J mice, 8 weeks of age, were divided into four groups with loading or unloading and administration of PTH (40 microg/kg body weight) or vehicle five times per week.
Summary · context
Mice were killed at 8 or 15 days, and both tibias were obtained.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1547658107
08AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In mice, unloading maintained the PTH-induced increase in Osterix mRNA.
In plain wordsIn mice, unloading preserved the PTH-related increase in Osterix mRNA compared with loading.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeOsterix mRNA
Study
mousen: not reported in source
Tail-suspended male C57BL/6J mice
Comparator
Loaded PTH-treated mice
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The PTH-induced increase in c-fos mRNA was depressed, but the increases in Osterix and RANKL mRNA were maintained.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty male C57BL/6J mice, 8 weeks of age, were divided into four groups with loading or unloading and administration of PTH (40 microg/kg body weight) or vehicle five times per week.
Summary · context
Mice were killed at 8 or 15 days, and both tibias were obtained.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1547658108
09AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism
In mice, unloading maintained the PTH-induced increase in RANKL mRNA.
In plain wordsIn mice, unloading preserved the PTH-related increase in RANKL mRNA compared with loading.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeRANKL mRNA
Study
mousen: not reported in source
Tail-suspended male C57BL/6J mice
Comparator
Loaded PTH-treated mice
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The PTH-induced increase in c-fos mRNA was depressed, but the increases in Osterix and RANKL mRNA were maintained.
2 context sentences(design, population, supporting numbers)
Summary · context
Eighty male C57BL/6J mice, 8 weeks of age, were divided into four groups with loading or unloading and administration of PTH (40 microg/kg body weight) or vehicle five times per week.
Summary · context
Mice were killed at 8 or 15 days, and both tibias were obtained.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1547658109

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

PepBank is a research reference. Talk to a doctor before you use any peptide.

Skeletal unloading alleviates the anabolic action of intermittent PTH(1-34) in mouse tibia in association with inhibition of PTH-induced increase in c-fos mRNA in bone marrow cells.

Summary

Results from this study9

Studies that did not test the peptide alone9

Version history

Subjects

Publication types

MeSH terms