Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofecoxib.

Dogan E, Saygili U, Posaci C, Tuna B, Caliskan S, Altunyurt S, Saatli B

Fertility and sterility1 Oct 2004Cited by 64 (Europe PMC)

PMID15474083DOI10.1016/j.fertnstert.2004.06.033PepBankPUB-15474083

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with endometriosis, implant size decreases were comparable with leuprolide and rofecoxib, at 64.3% and 62.4%, respectively.
In plain wordsIn rats with endometriosis, leuprolide and rofecoxib produced comparable implant shrinkage.
Peptide
Leuprolide
Outcome
DecreaseImplant size decrease versus rofecoxib
Study
ratn = 18
experimentally induced endometriosis
Comparator
Rofecoxib
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 mg/kg single depot injection · subcutaneous · 3 weeksAs given in this study (rat).
Measurements
Implant size decrease
64.3%
leuprolide
Implant size decrease
62.4%
rofecoxib
Source sentences
Summary
Three weeks of treatment with rofecoxib statistically significantly decreased the implant size (62.4%) compared with control (16.6%), and this effect was comparable with the decrease in leuprolide (64.3%).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-six rats with experimentally induced endometriosis.
Summary · context
Rats were treated for 3 weeks with oral rofecoxib (3 mg/kg per day; n = 9); single subcutaneous injection of depot leuprolide acetate (1 mg/kg; n = 9); or vehicle (control; n = 8).
Report a problemFND-1547408302
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with endometriosis, implant size decreased 64.3% with leuprolide versus 16.6% with control.
In plain wordsIn rats with endometriosis, implant size decreased more with leuprolide than with vehicle control.
Peptide
Leuprolide
Outcome
DecreaseImplant size decrease versus vehicle
Study
ratn = 17
experimentally induced endometriosis
Comparator
Vehicle control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 mg/kg single depot injection · subcutaneous · 3 weeksAs given in this study (rat).
Measurements
Implant size decrease
64.3%
leuprolide
Implant size decrease
16.6%
control
Source sentences
Summary
Three weeks of treatment with rofecoxib statistically significantly decreased the implant size (62.4%) compared with control (16.6%), and this effect was comparable with the decrease in leuprolide (64.3%).
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-six rats with experimentally induced endometriosis.
Summary · context
Rats were treated for 3 weeks with oral rofecoxib (3 mg/kg per day; n = 9); single subcutaneous injection of depot leuprolide acetate (1 mg/kg; n = 9); or vehicle (control; n = 8).
Report a problemFND-1547408301
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with endometriosis, semiquantitative explant scores were significantly lower with leuprolide than with control.
In plain wordsIn rats with endometriosis, explant scores were significantly lower with leuprolide than with control.
Peptide
Leuprolide
Outcome
DecreaseSemiquantitative histologic score
Study
ratn = 17
experimentally induced endometriosis
Comparator
Vehicle control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 mg/kg single depot injection · subcutaneous · 3 weeksAs given in this study (rat).
Source sentences
Summary
Histologic examination of the explants indicated mostly atrophy and regression in treatment groups, and semiquantitative analysis showed statistically significantly lower scores in rats treated with rofecoxib and leuprolide compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-six rats with experimentally induced endometriosis.
Summary · context
Rats were treated for 3 weeks with oral rofecoxib (3 mg/kg per day; n = 9); single subcutaneous injection of depot leuprolide acetate (1 mg/kg; n = 9); or vehicle (control; n = 8).
Report a problemFND-1547408304
04AnimalAnimal study (in vivo)Mechanism
In rats with endometriosis, leuprolide significantly decreased peritoneal VEGF levels compared with control.
In plain wordsIn rats with endometriosis, leuprolide reduced peritoneal VEGF levels compared with control.
Peptide
Leuprolide
Outcome
DecreasePeritoneal VEGF
Study
ratn = 17
experimentally induced endometriosis
Comparator
Vehicle control
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
1 mg/kg single depot injection · subcutaneous · 3 weeksAs given in this study (rat).
Source sentences
Summary
Both rofecoxib and leuprolide statistically significantly decreased VEGF levels compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-six rats with experimentally induced endometriosis.
Summary · context
Rats were treated for 3 weeks with oral rofecoxib (3 mg/kg per day; n = 9); single subcutaneous injection of depot leuprolide acetate (1 mg/kg; n = 9); or vehicle (control; n = 8).
Report a problemFND-1547408305
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with endometriosis, histologic examination showed mostly explant atrophy and regression in the leuprolide treatment group.
In plain wordsIn rats with endometriosis, explants mostly showed atrophy and regression after leuprolide treatment.
Peptide
Leuprolide
Outcome
Not applicableExplant atrophy and regression
Study
ratn = 9
experimentally induced endometriosis
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 mg/kg single depot injection · subcutaneous · 3 weeksAs given in this study (rat).
Source sentences
Summary
Histologic examination of the explants indicated mostly atrophy and regression in treatment groups, and semiquantitative analysis showed statistically significantly lower scores in rats treated with rofecoxib and leuprolide compared with controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-six rats with experimentally induced endometriosis.
Summary · context
Rats were treated for 3 weeks with oral rofecoxib (3 mg/kg per day; n = 9); single subcutaneous injection of depot leuprolide acetate (1 mg/kg; n = 9); or vehicle (control; n = 8).
Report a problemFND-1547408303

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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