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Study · Measured the body's own peptide · 2004

4 results

Beta-defensins and LL-37 in bronchoalveolar lavage fluid of patients with cystic fibrosis.

Chen CI, Schaller-Bals S, Paul KP, Wahn U, Bals R

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society1 Mar 2004Cited by 114 (Europe PMC)

PMID15463886 (opens in a new tab)DOI10.1016/j.jcf.2003.12.008 (opens in a new tab)PepBankPUB-15463886
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In bronchoalveolar lavage fluid of patients with cystic fibrosis, the body's own LL‑37 could be detected.

    In plain wordsThe body's own LL‑37 was found in lung fluid samples from people with cystic fibrosis.

    Peptide
    LL-37
    Outcome
    Not applicableLL-37 detection in bronchoalveolar lavage fluid
    Study

    n = 20

    Outcome group
    Infection and antimicrobial activity · Respiratory

    Source sentences

    Summary
    All three peptides could be detected in lavage fluid of the study population.
    1 context sentence
    Summary · context
    We measured the concentrations of hBD-1, hBD-2, and LL-37 in bronchoalveolar lavage fluid of 20 patients (5-34 years) participating in the prospective BEAT-study (bronchoalveolar lavage for the evaluation of anti-inflammatory treatment) using an immuno-dot blot-assay.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In patients with cystic fibrosis, higher lavage fluid total cell count was associated with higher concentrations of the body's own LL‑37/hCAP-18.

    In plain wordsIn people with cystic fibrosis, more lung inflammation cells were linked to higher levels of the body's own LL‑37.

    Peptide
    LL-37
    Outcome
    IncreaseLL-37/hCAP-18 versus total cell count in lavage fluid
    Study

    n = 20

    Outcome group
    Inflammation markers · Respiratory

    Measurements

    P value, total cell count
    0.006
    LL-37/hCAP-18 association

    Source sentences

    Summary
    Increased levels of inflammatory markers in bronchoalveolar lavage fluid were associated with elevated concentrations of LL-37/hCAP-18 (total cell count, P = 0.006
    1 context sentence
    Summary · context
    We measured the concentrations of hBD-1, hBD-2, and LL-37 in bronchoalveolar lavage fluid of 20 patients (5-34 years) participating in the prospective BEAT-study (bronchoalveolar lavage for the evaluation of anti-inflammatory treatment) using an immuno-dot blot-assay.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients with cystic fibrosis, higher relative neutrophil count in lavage fluid was associated with higher concentrations of the body's own LL‑37/hCAP-18.

    In plain wordsIn people with cystic fibrosis, more neutrophils in lung fluid were linked to higher levels of the body's own LL‑37.

    Peptide
    LL-37
    Outcome
    IncreaseLL-37/hCAP-18 versus relative neutrophil count in lavage fluid
    Study

    n = 20

    Outcome group
    Inflammation markers · Respiratory

    Measurements

    P value, relative neutrophil count
    0.002
    LL-37/hCAP-18 association

    Source sentences

    Summary
    Increased levels of inflammatory markers in bronchoalveolar lavage fluid were associated with elevated concentrations of LL-37/hCAP-18 (total cell count, P = 0.006; relative neutrophil count, P = 0.002).
    1 context sentence
    Summary · context
    We measured the concentrations of hBD-1, hBD-2, and LL-37 in bronchoalveolar lavage fluid of 20 patients (5-34 years) participating in the prospective BEAT-study (bronchoalveolar lavage for the evaluation of anti-inflammatory treatment) using an immuno-dot blot-assay.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In patients with cystic fibrosis, deterioration of lung function measured by MEF25 correlated with increased LL‑37/hCAP-18 concentrations.

    In plain wordsIn people with cystic fibrosis, worse lung function was linked to higher levels of the body's own LL‑37.

    Peptide
    LL-37
    Outcome
    IncreaseLL-37/hCAP-18 versus lung function (MEF25)
    Study

    n = 20

    Outcome group
    Inflammation markers · Respiratory

    Measurements

    P value, MEF25 correlation
    0.016
    LL-37/hCAP-18 concentration

    Source sentences

    Summary
    Deterioration of lung function, measured by MEF25 (maximal flow rate at 25% of residual forced vital capacity), correlated with decreased hBD-2 (P = 0.026), but increased LL-37/hCAP-18 concentrations (P = 0.016)
    1 context sentence
    Summary · context
    We measured the concentrations of hBD-1, hBD-2, and LL-37 in bronchoalveolar lavage fluid of 20 patients (5-34 years) participating in the prospective BEAT-study (bronchoalveolar lavage for the evaluation of anti-inflammatory treatment) using an immuno-dot blot-assay.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:59 UTC

    First added · source update from Europe PMC

Subjects

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