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Study · Ex vivo tissue · mouse (cba) · 2004

3 results

Effects of bioactive factors of the pineal gland on thymus function and cell composition of the bone marrow and spleen in mice of different age.

Labunets IF, Butenko GM, Khavinson VKh

Bulletin of experimental biology and medicine1 May 2004Cited by 2 (Europe PMC)

PMID15455131 (opens in a new tab)DOI10.1023/b:bebm.0000038166.54823.06 (opens in a new tab)PepBankPUB-15455131
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In thymus stroma cultures from mice of different age, Epithalon increased the titer of thymic serum factor.

    In plain wordsIn lab tests on mouse thymus cells, Epithalon raised the level of thymic serum factor.

    Peptide
    Epitalon
    Outcome
    IncreaseTiter of thymic serum factor in thymus stroma culture supernatant
    Study

    Mouse (CBA)n: not reported in source

    Thymus stroma, bone marrow and spleen cell cultures
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epithalamin, Epithalon, and melatonin appreciably increased the titer of thymic serum factor in the supernatant of thymus stroma cultures from mice of different age and increased the percentage of CD4+ cells in the bone marrow suspension from old animals in vitro.
    1 context sentence
    Summary · context
    The effects of factors from the pineal gland on the titer of thymic serum factor in the supernatant of 3-h thymus stroma cultures, number of stromal precursor fibroblasts and CD4+ cells in the bone marrow, and CD8+ cells in the spleens of adult and old CBA mice were studied in vitro.
  2. 02LabEx vivo tissueEfficacy outcome

    In bone marrow cells from old mice, Epithalon increased the percentage of CD4+ cells in vitro.

    In plain wordsIn lab tests on bone marrow cells from old mice, Epithalon raised the share of CD4+ cells.

    Peptide
    Epitalon
    Outcome
    IncreasePercentage of CD4+ cells in bone marrow suspension from old mice
    Study

    Mouse (CBA)n: not reported in source

    Thymus stroma, bone marrow and spleen cell cultures
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epithalamin, Epithalon, and melatonin appreciably increased the titer of thymic serum factor in the supernatant of thymus stroma cultures from mice of different age and increased the percentage of CD4+ cells in the bone marrow suspension from old animals in vitro.
    1 context sentence
    Summary · context
    The effects of factors from the pineal gland on the titer of thymic serum factor in the supernatant of 3-h thymus stroma cultures, number of stromal precursor fibroblasts and CD4+ cells in the bone marrow, and CD8+ cells in the spleens of adult and old CBA mice were studied in vitro.
  3. 03LabEx vivo tissueEfficacy outcome

    In bone marrow cells from adult and old mice, Epithalon did not appreciably change the percentage of fibroblast precursor cells.

    In plain wordsIn lab tests on mouse bone marrow cells, Epithalon did not clearly change the share of fibroblast precursor cells.

    Peptide
    Epitalon
    Outcome
    No significant changeBone marrow fibroblast precursor cells
    Study

    Mouse (CBA)n: not reported in source

    Thymus stroma, bone marrow and spleen cell cultures
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The percentage of bone marrow fibroblast precursor cells from adult and old mice did not appreciably change after incubation with the preparations.
    1 context sentence
    Summary · context
    The effects of factors from the pineal gland on the titer of thymic serum factor in the supernatant of 3-h thymus stroma cultures, number of stromal precursor fibroblasts and CD4+ cells in the bone marrow, and CD8+ cells in the spleens of adult and old CBA mice were studied in vitro.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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