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Study · In vitro (cells) · 2004

2 results

Peptide promotes overcoming of the division limit in human somatic cell.

Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD

Bulletin of experimental biology and medicine1 May 2004Cited by 8 (Europe PMC)

PMID15455129 (opens in a new tab)DOI10.1023/b:bebm.0000038164.49947.8c (opens in a new tab)PepBankPUB-15455129
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In aged human fetal fibroblasts, epithalon elongated telomeres to a size comparable to their length at early passages.

    In plain wordsIn human cells grown in the lab, epithalon lengthened telomeres in aged cells to about the length seen in early passages.

    Peptide
    Epitalon
    Outcome
    IncreaseTelomere length in aged fibroblasts
    Study

    humann: not reported in source

    human fetal pulmonary fibroblasts
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Addition of Epithalon to aging cells in culture induced elongation of telomeres to the size comparable to their length during early passages.
    2 context sentences
    Summary · context
    The mean size of telomeres in these cells was appreciably lower than during early passages (passage 10).
    Summary · context
    Primary pulmonary fibroblasts derived from a 24-week fetus lost the proliferative potential at the 34th passage.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human fetal fibroblasts, epithalon-treated cells with elongated telomeres made 10 extra divisions (44 passages) compared with control and continued dividing, which overcame the Hayflick limit.

    In plain wordsIn human cells grown in the lab, epithalon-treated cells divided 10 more times than untreated control cells and passed their usual division limit.

    Peptide
    Epitalon
    Outcome
    IncreaseExtra cell divisions before the division limit
    Study

    humann: not reported in source

    human fetal pulmonary fibroblasts
    Comparator
    Untreated control cells
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Measurements

    Extra divisions
    10 divisions
    epithalon-treated cells vs control
    Passages reached
    44 passages
    epithalon-treated cells

    Source sentences

    Summary
    Peptide-treated cells with elongated telomeres made 10 extra divisions (44 passages) in comparison with the control and continued dividing.
    2 context sentences
    Summary · context
    Hence, Epithalon prolonged the vital cycle of normal human cells due to overcoming the Heyflick limit.
    Summary · context
    Primary pulmonary fibroblasts derived from a 24-week fetus lost the proliferative potential at the 34th passage.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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