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Study · Animal study (in vivo) · mouse · 2004

2 results

Genotype-dependent changes in pain thresholds in adult mice after neonatal treatment.

Boyarshinova OS, Shilova OB, Markina NV, Gichenok IV, Perepelkina OV, Poletaeva II

Bulletin of experimental biology and medicine1 Jun 2004Cited by 3 (Europe PMC)

PMID15455076 (opens in a new tab)DOI10.1023/b:bebm.0000042703.99534.40 (opens in a new tab)PepBankPUB-15455076
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult DBA/2 male mice, neonatal Semax significantly increased pain thresholds compared with neonatal solvent.

    In plain wordsIn male mice, Semax given soon after birth raised pain thresholds in adulthood more than solvent did.

    Peptide
    Semax
    Outcome
    IncreasePain threshold in adult DBA/2 males
    Study

    mousen: not reported in source

    Mice of 6 genotypes, neonatal treatment
    Comparator
    Solvent
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · neonatal periodAs given in this study (mouse).

    Source sentences

    Summary
    Neonatal administration of Semax significantly increased pain thresholds in adult DBA/2 and 101/HY males compared to those in animals neonatally treated with the solvent.
    1 context sentence
    Summary · context
    We studied the effect of neonatal treatment with pharmacological preparations (Semax and buspiron) and solvents (distilled water and physiological saline) on the pain threshold in 3-4-month-old mice of 6 genotypes.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult 101/HY male mice, neonatal Semax significantly increased pain thresholds compared with neonatal solvent.

    In plain wordsIn male mice, Semax given soon after birth raised pain thresholds in adulthood more than solvent did.

    Peptide
    Semax
    Outcome
    IncreasePain threshold in adult 101/HY males
    Study

    mousen: not reported in source

    Mice of 6 genotypes, neonatal treatment
    Comparator
    Solvent
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · neonatal periodAs given in this study (mouse).

    Source sentences

    Summary
    Neonatal administration of Semax significantly increased pain thresholds in adult DBA/2 and 101/HY males compared to those in animals neonatally treated with the solvent.
    1 context sentence
    Summary · context
    We studied the effect of neonatal treatment with pharmacological preparations (Semax and buspiron) and solvents (distilled water and physiological saline) on the pain threshold in 3-4-month-old mice of 6 genotypes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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