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Study · Measured the body's own peptide · 2005

3 results

Mechanical signals and IGF-I gene splicing in vitro in relation to development of skeletal muscle.

Cheema U, Brown R, Mudera V, Yang SY, McGrouther G, Goldspink G

Journal of cellular physiology1 Jan 2005Cited by 81 (Europe PMC)

PMID15389530 (opens in a new tab)DOI10.1002/jcp.20107 (opens in a new tab)PepBankPUB-15389530
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In C2C12 cells in static 3D culture, MGF showed no significant constitutive expression.

    In plain wordsIn cells, the cells' own MGF was not made at a meaningful level without stretch.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF constitutive expression in static cultures
    Study

    n: not reported in source

    C2C12 cells in 3D culture under mechanical strain
    Comparator
    Stretched cultures
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    MGF), which is involved in the proliferation of mononucleated myoblasts that are required for secondary myotube formation and to establish the muscle satellite (stem) cell pool, showed no significant constitutive expression in static cultures
    1 context sentence
    Summary · context
    In order to study how mechanical signals influence this gene splicing in developing muscle, C2C12 cells were grown in three-dimensional (3D) culture and subjected to different regimens of mechanical strain.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In C2C12 cells, a single ramp stretch upregulated MGF expression.

    In plain wordsIn cells, one stretch raised the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF expression after a single ramp stretch
    Study

    n: not reported in source

    C2C12 cells in 3D culture under mechanical strain
    Comparator
    Static cultures
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    but was upregulated by a single ramp stretch and by cycling loading.
    1 context sentence
    Summary · context
    In order to study how mechanical signals influence this gene splicing in developing muscle, C2C12 cells were grown in three-dimensional (3D) culture and subjected to different regimens of mechanical strain.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In C2C12 cells, cycling loading upregulated MGF expression.

    In plain wordsIn cells, repeated stretch raised the cells' own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF expression after cycling loading
    Study

    n: not reported in source

    C2C12 cells in 3D culture under mechanical strain
    Comparator
    Static cultures
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    but was upregulated by a single ramp stretch and by cycling loading.
    1 context sentence
    Summary · context
    In order to study how mechanical signals influence this gene splicing in developing muscle, C2C12 cells were grown in three-dimensional (3D) culture and subjected to different regimens of mechanical strain.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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