Skip to content

Study · Measured the body's own peptide · 2004

4 results

Estrogen reduces serotonin-1A receptor-mediated oxytocin release and Galpha(i/o/z) proteins in the hypothalamus of ovariectomized rats.

D'Souza DN, Zhang Y, Damjanoska KJ, Carrasco GA, Sullivan NR, Garcia F, Battaglia G, Doncarlos LL, Muma NA, Van de Kar LD

Neuroendocrinology1 Jan 2004Cited by 21 (Europe PMC)

PMID15385710 (opens in a new tab)DOI10.1159/000080795 (opens in a new tab)PepBankPUB-15385710
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In ovariectomized rats, (+)8-OH-DPAT and (+/-)8-OH-DPAT produced a similar increase in plasma oxytocin.

    In plain wordsIn rats, a serotonin-receptor drug raised the body's own oxytocin in blood by a similar amount for both drug forms.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin response to 8-OH-DPAT
    Study

    Ratn: not reported in source

    Ovariectomized female rats
    Comparator
    (+/-)8-OH-DPAT versus (+)8-OH-DPAT
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    (+)8-OH-DPAT and (+/-)8-OH-DPAT produced a similar magnitude of increase in plasma levels of ACTH and oxytocin.
    2 context sentences
    Summary · context
    The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats.
    Summary · context
    We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 100, 200 or 500 microg/kg, s.c.) on plasma hormones in ovariectomized rats that received a daily injection o…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In ovariectomized rats, the maximal plasma oxytocin response to (+)8-OH-DPAT was reached at a dose of 200 microg/kg.

    In plain wordsIn rats, the body's own oxytocin in blood peaked at the 200 microg/kg dose of the serotonin-receptor drug.

    Peptide
    Oxytocin
    Outcome
    IncreaseMaximal plasma oxytocin response dose
    Study

    Ratn: not reported in source

    Ovariectomized female rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    the maximal oxytocin response was achieved with a dose of 200 microg/kg, s.c.
    2 context sentences
    Summary · context
    The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats.
    Summary · context
    We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 100, 200 or 500 microg/kg, s.c.) on plasma hormones in ovariectomized rats that received a daily injection o…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In ovariectomized rats, estrogen treatment reduced the plasma oxytocin response to the highest dose of 8-OH-DPAT but did not alter the ACTH response.

    In plain wordsIn rats, estrogen lowered the rise in the body's own oxytocin in blood after a serotonin-receptor drug.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin response to 8-OH-DPAT with estrogen
    Study

    Ratn: not reported in source

    Ovariectomized female rats
    Comparator
    Vehicle (sesame oil)
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Treatment with beta-estradiol 3-benzoate produced a significant and comparable reduction in the oxytocin response to the highest dose (200 microg/kg, s.c.) of both (+)8-OH-DPAT and (+/-)8-OH-DPAT but did not alter the ACTH response to either (+)8-OH-DPAT or (+/-)8-OH-DPAT.
    2 context sentences
    Summary · context
    The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats.
    Summary · context
    We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 100, 200 or 500 microg/kg, s.c.) on plasma hormones in ovariectomized rats that received a daily injection o…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In ovariectomized rats, estrogen treatment reduced the maximal plasma oxytocin response to (+)8-OH-DPAT by 29%.

    In plain wordsIn rats, estrogen cut the peak rise in the body's own oxytocin in blood by 29%.

    Peptide
    Oxytocin
    Outcome
    DecreaseMaximal oxytocin response to (+)8-OH-DPAT with estrogen
    Study

    Ratn: not reported in source

    Ovariectomized female rats
    Comparator
    Vehicle (sesame oil)
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    Reduction in maximal oxytocin response
    29%
    estrogen versus vehicle

    Source sentences

    Summary
    Treatment with beta-estradiol 3-benzoate reduced the maximal oxytocin response to (+)8-OH-DPAT (by 29%)
    2 context sentences
    Summary · context
    The present study examined the effect of estradiol on hypothalamic serotonin-1A (5-HT(1A)) receptor signaling in female rats.
    Summary · context
    We first examined the time-course effects of a single injection of the 5-HT(1A) receptor agonist (+/-)8-OH-DPAT (5, 15 or 30 min prior to decapitation), and dose response of (+)8-OH-DPAT (50, 100, 200 or 500 microg/kg, s.c.) on plasma hormones in ovariectomized rats that received a daily injection o…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.