Serum thymic factor prevents LPS-induced pancreatic cell damage in mice via up-regulation of Bcl-2 expression in pancreas.

Saitoh N, Awaya A, Sakudo A, SungWook S, Saeki K, Matsumoto Y, Onodera T

Microbiology and immunology1 Jan 2004Cited by 15 (Europe PMC)

PMID15383698DOI10.1111/j.1348-0421.2004.tb03471.xPepBankPUB-15383698

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In LPS-treated mice, FTS prevented visible morphological changes in pancreatic cells.
In plain wordsIn mice, FTS prevented visible pancreatic cell damage compared with LPS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreasePancreatic morphological damage
Study
mousen: not reported in source
LPS-induced pancreatic injury in BALB/c male mice
Comparator
LPS without FTS
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
50 micro g/head before LPS and 50 micro g/head immediately before LPS · intraperitonealAs given in this study (mouse).
Source sentences
Summary
In contrast, morphological change was not seen and apoptotic cell death was suppressed in pancreatic cells of FTS-administered mice.
2 context sentences(design, population, supporting numbers)
Summary · context
The protective effect of synthetic serum thymic factor (FTS) nonapeptide on lipopolysaccharide (LPS)-induced pancreatic cell damage in 10-week-old BALB/c male mice was investigated.
Summary · context
Group II was administered with FTS (50 micro g/head; i.p.) 24 hr before treatment with LPS and complemented immediately before LPS injection with FTS (50 micro g/head; i.p.) (FTS-administered mice).
Report a problemFND-1538369801
02AnimalAnimal study (in vivo)Mechanism
In LPS-treated mice, FTS suppressed pancreatic cell apoptosis.
In plain wordsIn mice, FTS reduced pancreatic cell death compared with LPS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreasePancreatic cell apoptosis
Study
mousen: not reported in source
LPS-induced pancreatic injury in BALB/c male mice
Comparator
LPS without FTS
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
50 micro g/head before LPS and 50 micro g/head immediately before LPS · intraperitonealAs given in this study (mouse).
Source sentences
Summary
In contrast, morphological change was not seen and apoptotic cell death was suppressed in pancreatic cells of FTS-administered mice.
2 context sentences(design, population, supporting numbers)
Summary · context
The protective effect of synthetic serum thymic factor (FTS) nonapeptide on lipopolysaccharide (LPS)-induced pancreatic cell damage in 10-week-old BALB/c male mice was investigated.
Summary · context
Group II was administered with FTS (50 micro g/head; i.p.) 24 hr before treatment with LPS and complemented immediately before LPS injection with FTS (50 micro g/head; i.p.) (FTS-administered mice).
Report a problemFND-1538369802
03AnimalAnimal study (in vivo)Mechanism
In LPS-treated mice, FTS maintained normal insulin expression, whereas LPS alone caused low or absent expression.
In plain wordsIn mice, FTS maintained normal insulin expression compared with low or absent expression after LPS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreasePancreatic insulin expression
Study
mousen: not reported in source
LPS-induced pancreatic injury in BALB/c male mice
Comparator
LPS without FTS
Outcome group
Glycemic control · Endocrine and hormones
Studied dose
50 micro g/head before LPS and 50 micro g/head immediately before LPS · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Moreover, insulin expression was normal in those mice.
3 context sentences(design, population, supporting numbers)
Summary · context
Immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) revealed that LPS treatment also caused low or a lack of insulin expression in pancreatic islets.
Summary · context
The protective effect of synthetic serum thymic factor (FTS) nonapeptide on lipopolysaccharide (LPS)-induced pancreatic cell damage in 10-week-old BALB/c male mice was investigated.
Summary · context
Group II was administered with FTS (50 micro g/head; i.p.) 24 hr before treatment with LPS and complemented immediately before LPS injection with FTS (50 micro g/head; i.p.) (FTS-administered mice).
Report a problemFND-1538369803
04AnimalAnimal study (in vivo)Mechanism
In LPS-treated mice, FTS increased pancreatic Bcl-2 mRNA compared with LPS alone at 3 hr.
In plain wordsIn mice, FTS increased pancreatic Bcl-2 gene activity compared with LPS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreasePancreatic Bcl-2 mRNA
Study
mousen: not reported in source
LPS-induced pancreatic injury in BALB/c male mice
Comparator
LPS without FTS
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
50 micro g/head before LPS and 50 micro g/head immediately before LPS · intraperitonealAs given in this study (mouse).
Source sentences
Summary
FTS administration enhanced expression of Bcl-2 mRNA levels in pancreatic tissues and IL-6 mRNA levels in splenocytes significantly compared with those of LPS treatment at 3 hr after LPS injection.
2 context sentences(design, population, supporting numbers)
Summary · context
The protective effect of synthetic serum thymic factor (FTS) nonapeptide on lipopolysaccharide (LPS)-induced pancreatic cell damage in 10-week-old BALB/c male mice was investigated.
Summary · context
Group II was administered with FTS (50 micro g/head; i.p.) 24 hr before treatment with LPS and complemented immediately before LPS injection with FTS (50 micro g/head; i.p.) (FTS-administered mice).
Report a problemFND-1538369804
05AnimalAnimal study (in vivo)Mechanism
In LPS-treated mice, FTS increased splenocyte IL-6 mRNA compared with LPS alone at 3 hr.
In plain wordsIn mice, FTS increased IL-6 gene activity in spleen cells compared with LPS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSplenocyte IL-6 mRNA
Study
mousen: not reported in source
LPS-induced pancreatic injury in BALB/c male mice
Comparator
LPS without FTS
Outcome group
Immune response · Immune and inflammation
Studied dose
50 micro g/head before LPS and 50 micro g/head immediately before LPS · intraperitonealAs given in this study (mouse).
Source sentences
Summary
FTS administration enhanced expression of Bcl-2 mRNA levels in pancreatic tissues and IL-6 mRNA levels in splenocytes significantly compared with those of LPS treatment at 3 hr after LPS injection.
2 context sentences(design, population, supporting numbers)
Summary · context
The protective effect of synthetic serum thymic factor (FTS) nonapeptide on lipopolysaccharide (LPS)-induced pancreatic cell damage in 10-week-old BALB/c male mice was investigated.
Summary · context
Group II was administered with FTS (50 micro g/head; i.p.) 24 hr before treatment with LPS and complemented immediately before LPS injection with FTS (50 micro g/head; i.p.) (FTS-administered mice).
Report a problemFND-1538369805

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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