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Study · Not a test of the peptide alone · 2004

2 results

Permeability to water in a tight epithelium: possible modulating action of gap junctions.

Orce G, Castillo G, Chanampa Y, Bellomio A

Canadian journal of physiology and pharmacology1 Jun 2004Cited by 4 (Europe PMC)

PMID15381966 (opens in a new tab)DOI10.1139/y04-037 (opens in a new tab)PepBankPUB-15381966
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In isolated toad urinary bladders, the gap junction inhibitor octanol reduced the osmotic water flow stimulated by oxytocin.

    In plain wordsIn lab tests on toad bladders, a gap junction blocker reduced the water flow that oxytocin triggers.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-stimulated osmotic water flow with octanol
    Study

    Toadn = 6

    Isolated toad urinary bladder
    Comparator
    Oxytocin without octanol
    Outcome group
    Kidney function · Kidney and urinary

    Measurements

    Jw with oxytocin
    185.3 mg.20 min(-1)
    oxytocin 50 mIU/mL
    Jw with oxytocin and octanol
    69 mg.20 min(-1)
    oxytocin 50 mIU/mL plus octanol

    Source sentences

    Summary
    Octanol, 1.2 x 10(-3) M, a gap junction inhibitor, significantly reduced Jw (expressed as mg.20 min(-1)) in isolated toad urinary bladders (a model of the distal nephron) subjected to a transepithelial osmotic gradient and exposed to agents mimicking the vasopressin-triggered mechanism: oxytocin, 50…
    1 context sentence
    Summary · context
    Osmotic water flow (Jw) across tight distal nephron epithelial membranes increases upon exposure to vasopressin: following binding of the hormone to its receptors, intracellular cyclic AMP concentration increases, leading to insertion of aquaporins in the apical membrane.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In isolated toad urinary bladders, the gap junction blocker carbenoxolone reduced the osmotic water flow stimulated by oxytocin.

    In plain wordsIn lab tests on toad bladders, a second gap junction blocker also reduced the water flow that oxytocin triggers.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-stimulated osmotic water flow with carbenoxolone
    Study

    Toadn = 6

    Isolated toad urinary bladder
    Comparator
    Oxytocin without carbenoxolone
    Outcome group
    Kidney function · Kidney and urinary

    Measurements

    Jw with oxytocin
    256.7 mg.20 min(-1)
    oxytocin 100 mIU/mL
    Jw with oxytocin and carbenoxolone
    102.7 mg.20 min(-1)
    oxytocin 100 mIU/mL plus carbenoxolone

    Source sentences

    Summary
    Another gap junction blocker, carbenoxolone, 2.0 x 10(-4) M (CBX), exerted similar effects on the responses to oxytocin, 100 mIU.mL(-1), reducing the response from 256.7 +/- 33.6, P < 0.001, to 102.7 +/- 10.4, P < 0.001; Pdiff < 0.01, n = 6) and nystatin, which was unaffected (95.0 +/- 20.9, P < 0.0…
    1 context sentence
    Summary · context
    Osmotic water flow (Jw) across tight distal nephron epithelial membranes increases upon exposure to vasopressin: following binding of the hormone to its receptors, intracellular cyclic AMP concentration increases, leading to insertion of aquaporins in the apical membrane.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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