Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake.

Verty AN, McFarlane JR, McGregor IS, Mallet PE

Neuropharmacology1 Sept 2004Cited by 45 (Europe PMC)

PMID15380376DOI10.1016/j.neuropharm.2004.06.002PepBankPUB-15380376

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, intracerebroventricular oxytocin alone dose-dependently attenuated baseline food intake.
In plain wordsIn rats, oxytocin given into the brain lowered food intake in a dose-dependent way.
Peptide
Oxytocin
Outcome
DecreaseBaseline food intake
Study
Ratn: not reported in source
Rats with ICV injections
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 120 min measurementAs given in this study (Rat).
Source sentences
Summary
When administrated alone, SR 141716 and oxytocin dose-dependently attenuated baseline food intake, while oxytocin but not SR 141716 reduced water intake.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were habituated to the test environment and injection procedure, and then received intracerebroventricular (ICV) injections of various combinations of the oxytocin receptor antagonist tocinoic acid, the cannabionid receptor agonist delta(9)-tetrahydrocannabinol (THC), oxytocin, or the cannabino…
Summary · context
Food and water intake and locomotor activity were then measured for 120 min.
Report a problemFND-1538037601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, intracerebroventricular oxytocin alone reduced baseline water intake.
In plain wordsIn rats, oxytocin given into the brain lowered water intake.
Peptide
Oxytocin
Outcome
DecreaseBaseline water intake
Study
Ratn: not reported in source
Rats with ICV injections
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 120 min measurementAs given in this study (Rat).
Source sentences
Summary
When administrated alone, SR 141716 and oxytocin dose-dependently attenuated baseline food intake, while oxytocin but not SR 141716 reduced water intake.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were habituated to the test environment and injection procedure, and then received intracerebroventricular (ICV) injections of various combinations of the oxytocin receptor antagonist tocinoic acid, the cannabionid receptor agonist delta(9)-tetrahydrocannabinol (THC), oxytocin, or the cannabino…
Summary · context
Food and water intake and locomotor activity were then measured for 120 min.
Report a problemFND-1538037602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, oxytocin did not block THC-induced feeding.
In plain wordsIn rats, oxytocin did not stop the extra eating caused by THC.
Peptide
Oxytocin
Outcome
No significant changeTHC-induced feeding
Study
Ratn: not reported in source
Rats with ICV injections
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 120 min measurementAs given in this study (Rat).
Source sentences
Summary
THC-induced feeding was not blocked by oxytocin
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were habituated to the test environment and injection procedure, and then received intracerebroventricular (ICV) injections of various combinations of the oxytocin receptor antagonist tocinoic acid, the cannabionid receptor agonist delta(9)-tetrahydrocannabinol (THC), oxytocin, or the cannabino…
Summary · context
Food and water intake and locomotor activity were then measured for 120 min.
Report a problemFND-1538037605
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, oxytocin attenuated water intake during THC-induced feeding.
In plain wordsIn rats, oxytocin lowered water intake during THC-driven eating.
Peptide
Oxytocin
Outcome
DecreaseWater intake during THC-induced feeding
Study
Ratn: not reported in source
Rats with ICV injections
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 120 min measurementAs given in this study (Rat).
Source sentences
Summary
the oxytocin did attenuate water intake during such feeding.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were habituated to the test environment and injection procedure, and then received intracerebroventricular (ICV) injections of various combinations of the oxytocin receptor antagonist tocinoic acid, the cannabionid receptor agonist delta(9)-tetrahydrocannabinol (THC), oxytocin, or the cannabino…
Summary · context
Food and water intake and locomotor activity were then measured for 120 min.
Report a problemFND-1538037606

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In rats, sub-anorectic doses of oxytocin and SR 141716 together attenuated baseline feeding beyond the sum of the individual effects.
In plain wordsIn rats, small doses of oxytocin with a CB1 blocker together lowered feeding more than the two added up.
Peptide
Oxytocin
Outcome
DecreaseBaseline feeding with sub-anorectic oxytocin plus SR 141716
Study
Ratn: not reported in source
Rats with ICV injections
Outcome group
Appetite and food intake · Metabolic and weight
Source sentences
Summary
Sub-anorectic doses of SR 141716 and oxytocin attenuated baseline feeding beyond what would be expected by the sum of the individual drug effects
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were habituated to the test environment and injection procedure, and then received intracerebroventricular (ICV) injections of various combinations of the oxytocin receptor antagonist tocinoic acid, the cannabionid receptor agonist delta(9)-tetrahydrocannabinol (THC), oxytocin, or the cannabino…
Summary · context
Food and water intake and locomotor activity were then measured for 120 min.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1538037603
06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In rats, sub-anorectic doses of oxytocin and SR 141716 together did not affect baseline water intake.
In plain wordsIn rats, small doses of oxytocin with a CB1 blocker together did not change water intake.
Peptide
Oxytocin
Outcome
No significant changeBaseline water intake with sub-anorectic oxytocin plus SR 141716
Study
Ratn: not reported in source
Rats with ICV injections
Outcome group
Appetite and food intake · Metabolic and weight
Source sentences
Summary
without affecting baseline water intake.
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were habituated to the test environment and injection procedure, and then received intracerebroventricular (ICV) injections of various combinations of the oxytocin receptor antagonist tocinoic acid, the cannabionid receptor agonist delta(9)-tetrahydrocannabinol (THC), oxytocin, or the cannabino…
Summary · context
Food and water intake and locomotor activity were then measured for 120 min.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1538037604
07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Safety outcome
In rats, locomotor activity was not significantly affected by any of the drug treatments, which included oxytocin among other drugs.
In plain wordsIn rats, none of the drug treatments, oxytocin among them, changed movement significantly.
Peptide
Oxytocin
Outcome
No significant changeLocomotor activity across drug treatments
Study
Ratn: not reported in source
Rats with ICV injections
Outcome group
Adverse events · Nervous system and cognition
Source sentences
Summary
Locomotor activity was not significantly affected by any drug treatments
2 context sentences(design, population, supporting numbers)
Summary · context
Rats were habituated to the test environment and injection procedure, and then received intracerebroventricular (ICV) injections of various combinations of the oxytocin receptor antagonist tocinoic acid, the cannabionid receptor agonist delta(9)-tetrahydrocannabinol (THC), oxytocin, or the cannabino…
Summary · context
Food and water intake and locomotor activity were then measured for 120 min.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1538037607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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