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Study · Randomized controlled trial · n = 41 · 1990

7 results

A multidimensional approach in testing nootropic drug effects (Cerebrolysin).

Kofler B, Erhart C, Erhart P, Harrer G

Archives of gerontology and geriatrics1 Mar 1990Cited by 10 (Europe PMC)

PMID15374509 (opens in a new tab)DOI10.1016/0167-4943(90)90014-w (opens in a new tab)PepBankPUB-15374509
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In geriatric patients with organic brain syndrome, SCAG changes favored cerebrolysin plus multivitamins over multivitamins alone.

    In plain wordsIn geriatric patients, SCAG changes favored cerebrolysin plus multivitamins over multivitamins alone.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedSCAG clinical scale
    Study

    n = 41

    Comparator
    Multivitamin infusions alone
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Treatment group size
    27 patients
    Cerebrolysin plus multivitamin infusions in the SCAG comparison
    Comparison group size
    14 patients
    Multivitamin infusions alone in the SCAG comparison

    Source sentences

    Summary
    Pre-posttreatment differences from (1) clinical scales (SCAG, Plutchik Geriatric Rating Scale and a self-evaluation scale); (2) psychometric test performance (trail-making and maze subtests from the Nürnberg Age Inventory); and (3) event-related brain activity (contingent negative variation (CNV) am…
    2 context sentences
    Summary · context
    A group of 27 geriatric patients suffering from an organic brain syndrome with moderate cognitive impairment of a vascular or/and degenerative nature received a series of ten Cerebrolysin + multivitamin infusions.
    Summary · context
    They were compared to a second group with 14 clinically comparable patients, who received multivitamin infusions alone.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In geriatric patients with organic brain syndrome, Plutchik Geriatric Rating Scale changes favored cerebrolysin plus multivitamins over multivitamins alone.

    In plain wordsIn geriatric patients, Plutchik Geriatric Rating Scale changes favored cerebrolysin plus multivitamins over multivitamins alone.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedPlutchik Geriatric Rating Scale
    Study

    n = 41

    Comparator
    Multivitamin infusions alone
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pre-posttreatment differences from (1) clinical scales (SCAG, Plutchik Geriatric Rating Scale and a self-evaluation scale); (2) psychometric test performance (trail-making and maze subtests from the Nürnberg Age Inventory); and (3) event-related brain activity (contingent negative variation (CNV) am…
    2 context sentences
    Summary · context
    A group of 27 geriatric patients suffering from an organic brain syndrome with moderate cognitive impairment of a vascular or/and degenerative nature received a series of ten Cerebrolysin + multivitamin infusions.
    Summary · context
    They were compared to a second group with 14 clinically comparable patients, who received multivitamin infusions alone.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In geriatric patients with organic brain syndrome, self-evaluation scale changes favored cerebrolysin plus multivitamins over multivitamins alone.

    In plain wordsIn geriatric patients, self-evaluation scale changes favored cerebrolysin plus multivitamins over multivitamins alone.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedSelf-evaluation scale
    Study

    n = 41

    Comparator
    Multivitamin infusions alone
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pre-posttreatment differences from (1) clinical scales (SCAG, Plutchik Geriatric Rating Scale and a self-evaluation scale); (2) psychometric test performance (trail-making and maze subtests from the Nürnberg Age Inventory); and (3) event-related brain activity (contingent negative variation (CNV) am…
    2 context sentences
    Summary · context
    A group of 27 geriatric patients suffering from an organic brain syndrome with moderate cognitive impairment of a vascular or/and degenerative nature received a series of ten Cerebrolysin + multivitamin infusions.
    Summary · context
    They were compared to a second group with 14 clinically comparable patients, who received multivitamin infusions alone.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In geriatric patients with organic brain syndrome, trail-making performance changes favored cerebrolysin plus multivitamins over multivitamins alone.

    In plain wordsIn geriatric patients, trail-making performance changes favored cerebrolysin plus multivitamins over multivitamins alone.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedTrail-making test performance
    Study

    n = 41

    Comparator
    Multivitamin infusions alone
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pre-posttreatment differences from (1) clinical scales (SCAG, Plutchik Geriatric Rating Scale and a self-evaluation scale); (2) psychometric test performance (trail-making and maze subtests from the Nürnberg Age Inventory); and (3) event-related brain activity (contingent negative variation (CNV) am…
    2 context sentences
    Summary · context
    A group of 27 geriatric patients suffering from an organic brain syndrome with moderate cognitive impairment of a vascular or/and degenerative nature received a series of ten Cerebrolysin + multivitamin infusions.
    Summary · context
    They were compared to a second group with 14 clinically comparable patients, who received multivitamin infusions alone.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In geriatric patients with organic brain syndrome, maze performance changes favored cerebrolysin plus multivitamins over multivitamins alone.

    In plain wordsIn geriatric patients, maze performance changes favored cerebrolysin plus multivitamins over multivitamins alone.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedMaze test performance
    Study

    n = 41

    Comparator
    Multivitamin infusions alone
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pre-posttreatment differences from (1) clinical scales (SCAG, Plutchik Geriatric Rating Scale and a self-evaluation scale); (2) psychometric test performance (trail-making and maze subtests from the Nürnberg Age Inventory); and (3) event-related brain activity (contingent negative variation (CNV) am…
    2 context sentences
    Summary · context
    A group of 27 geriatric patients suffering from an organic brain syndrome with moderate cognitive impairment of a vascular or/and degenerative nature received a series of ten Cerebrolysin + multivitamin infusions.
    Summary · context
    They were compared to a second group with 14 clinically comparable patients, who received multivitamin infusions alone.
  6. 06HumanRandomized controlled trialActivity measurement

    In geriatric patients with organic brain syndrome, CNV amplitude changes favored cerebrolysin plus multivitamins over multivitamins alone.

    In plain wordsIn geriatric patients, CNV amplitude changes favored cerebrolysin plus multivitamins over multivitamins alone.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedCNV amplitude
    Study

    n = 41

    Comparator
    Multivitamin infusions alone
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pre-posttreatment differences from (1) clinical scales (SCAG, Plutchik Geriatric Rating Scale and a self-evaluation scale); (2) psychometric test performance (trail-making and maze subtests from the Nürnberg Age Inventory); and (3) event-related brain activity (contingent negative variation (CNV) am…
    2 context sentences
    Summary · context
    A group of 27 geriatric patients suffering from an organic brain syndrome with moderate cognitive impairment of a vascular or/and degenerative nature received a series of ten Cerebrolysin + multivitamin infusions.
    Summary · context
    They were compared to a second group with 14 clinically comparable patients, who received multivitamin infusions alone.

Studies that did not test the peptide alone1

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 07HumanNot a test of Cerebrolysin aloneRandomized controlled trialOther

    In geriatric patients, multidimensional measures of cerebrolysin treatment showed high association and 95% joint correct classification.

    In plain wordsIn geriatric patients, combined measurements of cerebrolysin treatment showed strong association and 95% correct classification.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableJoint classification accuracy
    Study

    n = 41

    Outcome group
    Analytical methods and detection · Nervous system and cognition

    Measurements

    Joint correct classification
    95%
    multidimensional measures

    Source sentences

    Summary
    A high degree of association as well as high classification rates (95% joint correct classification) underlined their clinical significance.
    2 context sentences
    Summary · context
    A group of 27 geriatric patients suffering from an organic brain syndrome with moderate cognitive impairment of a vascular or/and degenerative nature received a series of ten Cerebrolysin + multivitamin infusions.
    Summary · context
    They were compared to a second group with 14 clinically comparable patients, who received multivitamin infusions alone.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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