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Study · Animal study (in vivo) · rat · 2004

3 results

Delta-sleep inducing peptide and neuronal activity after glutamate microiontophoresis: the role of NMDA-receptors.

Sudakov KV, Umriukhin PE, Rayevsky KS

Pathophysiology : the official journal of the International Society for Pathophysiology1 Oct 2004Cited by 8 (Europe PMC)

PMID15364118 (opens in a new tab)DOI10.1016/j.pathophys.2004.03.003 (opens in a new tab)PepBankPUB-15364118
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male Wistar rats, DSIP microiontophoresis predominantly activated neurons in brain regions, in particular dorsal hippocampus and ventral anterior thalamic nucleus.

    In plain wordsIn rats, DSIP applied to brain cells mostly made neurons more active, especially in the hippocampus and thalamus.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNeuronal activity
    Study

    ratn: not reported in source

    microiontophoresis in male Wistar rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Source sentences

    Summary
    DSIP microiontophoresis predominantly activated neurons of various brain regions, in particular, dorsal hippocampus and ventral anterior thalamic nucleus.
    1 context sentence
    Summary · context
    The influence of microiontophoretic application of delta-sleep inducing peptide (DSIP) on a neuronal activity of sensorimotor brain cortex, dorsal hippocampus, ventral anterior thalamic nucleus and lateral hypothalamus was studied under the effects of glutamate and MK-801, a N-methyl-d-aspartate non…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male Wistar rats, preliminary DSIP microiontophoresis prevented the increase in neuronal activity under glutamate microiontophoresis.

    In plain wordsIn rats, DSIP applied first stopped glutamate from raising brain cell activity.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseGlutamate-induced neuronal activity
    Study

    ratn: not reported in source

    microiontophoresis in male Wistar rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Source sentences

    Summary
    A preliminary DSIP microiontophoresis prevented the augmentation of a neuronal activity in the studied structures under glutamate microiontophoresis.
    1 context sentence
    Summary · context
    The influence of microiontophoretic application of delta-sleep inducing peptide (DSIP) on a neuronal activity of sensorimotor brain cortex, dorsal hippocampus, ventral anterior thalamic nucleus and lateral hypothalamus was studied under the effects of glutamate and MK-801, a N-methyl-d-aspartate non…

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In male Wistar rats, after MK-801 microiontophoresis the number of neurons activated by DSIP decreased significantly.

    In plain wordsIn rats, after the NMDA blocker MK-801, fewer brain cells were activated by DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseNeurons activated by DSIP after MK-801
    Study

    ratn: not reported in source

    microiontophoresis in male Wistar rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    After MK-801 microiontophoresis the number of neurons activated by the DSIP significantly decreased.
    1 context sentence
    Summary · context
    The influence of microiontophoretic application of delta-sleep inducing peptide (DSIP) on a neuronal activity of sensorimotor brain cortex, dorsal hippocampus, ventral anterior thalamic nucleus and lateral hypothalamus was studied under the effects of glutamate and MK-801, a N-methyl-d-aspartate non…

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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