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Study · Animal study (in vivo) · rat · 2004

3 results

[Morphochemical characteristic of rat brain structures after exposure to delta-sleep inducing peptide following long-term amphetamine administration].

Gershteĭn LM, Dovedova EL, Khrustalev DA

Morfologiia (Saint Petersburg, Russia)1 Jan 2004Cited by 1 (Europe PMC)

PMID15359701 (opens in a new tab)PepBankPUB-15359701
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given amphetamine for 3 weeks, a single intraperitoneal injection of DSIP at 60 microg/kg normalized brain metabolism that the drug had disturbed.

    In plain wordsIn rats given amphetamine for weeks, one DSIP injection brought disturbed brain metabolism back toward normal.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedBrain metabolism after long-term amphetamine
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    60 µg/kg · intraperitoneal · single injectionAs given in this study (rat).

    Source sentences

    Summary
    Single intraperitoneal injection of 60 microg/kg of DSIP following a long term amphetamine administration (2.5 mg/kg for 3 weeks) was shown to result in normalization of brain metabolism, that was disturbed by the drug.
    1 context sentence
    Summary · context
    The aim of this work, that was carried out using Wistar rats, was to characterize the response of neurons of different morphofunctional types to amphetamine administration and to study the possibility of correction of these changes by delta-sleep inducing peptide (DSIP).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given amphetamine for 3 weeks, DSIP corrected the state of proteins in neurons of the sensomotor cortex and caudate nucleus.

    In plain wordsIn rats given amphetamine for weeks, DSIP corrected protein changes in neurons of two brain areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedState of proteins in neurons of sensorimotor cortex and caudate nucleus
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    60 µg/kg · intraperitoneal · single injectionAs given in this study (rat).

    Source sentences

    Summary
    The correcting DSIP effect was found in rat brain structures judging by the parameters of the state of proteins in neurons of sensomotor cortex and caudate nucleus and by the activity of enzymes of neurotransmitter metabolism, such as type A and B monoamine oxidases and acetylcholine esterase, that…
    2 context sentences
    Summary · context
    Single intraperitoneal injection of 60 microg/kg of DSIP following a long term amphetamine administration (2.5 mg/kg for 3 weeks)
    Summary · context
    The aim of this work, that was carried out using Wistar rats, was to characterize the response of neurons of different morphofunctional types to amphetamine administration and to study the possibility of correction of these changes by delta-sleep inducing peptide (DSIP).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats given amphetamine for 3 weeks, DSIP corrected the activity of monoamine oxidases A and B and acetylcholine esterase in the sensomotor cortex and caudate nucleus.

    In plain wordsIn rats given amphetamine for weeks, DSIP corrected the activity of three brain enzymes in two brain areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedActivity of monoamine oxidases A and B and acetylcholine esterase
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    60 µg/kg · intraperitoneal · single injectionAs given in this study (rat).

    Source sentences

    Summary
    The correcting DSIP effect was found in rat brain structures judging by the parameters of the state of proteins in neurons of sensomotor cortex and caudate nucleus and by the activity of enzymes of neurotransmitter metabolism, such as type A and B monoamine oxidases and acetylcholine esterase, that…
    2 context sentences
    Summary · context
    Single intraperitoneal injection of 60 microg/kg of DSIP following a long term amphetamine administration (2.5 mg/kg for 3 weeks)
    Summary · context
    The aim of this work, that was carried out using Wistar rats, was to characterize the response of neurons of different morphofunctional types to amphetamine administration and to study the possibility of correction of these changes by delta-sleep inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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