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Study · In vitro (cells) · 2004

1 result

Overexpression and functional characterisation of the human melanocortin 4 receptor in Sf9 cells.

Dolby V, Collén A, Lundqvist A, Cronet P

Protein expression and purification1 Oct 2004Cited by 8 (Europe PMC)

PMID15358370 (opens in a new tab)DOI10.1016/j.pep.2004.06.018 (opens in a new tab)PepBankPUB-15358370
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In Sf9 cells expressing human MC4r, the Ki value of MTII was comparable to the value at MC4r expressed in mammalian cells.

    In plain wordsIn cells, melanotan II bound the receptor made in insect cells about as strongly as the receptor made in mammalian cells.

    Peptide
    Melanotan II
    Outcome
    No significant changeMTII binding affinity (Ki) at recombinant MC4r
    Study

    n: not reported in source

    Sf9 insect cells expressing human MC4r
    Comparator
    MC4r expressed in mammalian cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ki values for the ligands MTII, HS014, alpha-, beta-, and gamma-MSH are comparable to the values obtained for MC4r expressed in mammalian cells.
    1 context sentence
    Summary · context
    The human melanocortin 4 receptor (MC4r) was successfully expressed in Sf9 cells using the baculovirus infection system.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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