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Study · Measured the body's own peptide · 2004

2 results

Timed hypocaloric food restriction alters the synthesis and expression of vasopressin and vasoactive intestinal peptide in the suprachiasmatic nucleus.

Andrade JP, Pereira PA, Silva SM, Sá SI, Lukoyanov NV

Brain research1 Oct 2004Cited by 15 (Europe PMC)

PMID15353233 (opens in a new tab)DOI10.1016/j.brainres.2004.07.013 (opens in a new tab)PepBankPUB-15353233
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adult rats, timed hypocaloric food restriction decreased the total number of VIP-immunoreactive neurons in the suprachiasmatic nucleus.

    In plain wordsIn rats on timed low-calorie feeding, the body's own VIP-producing neurons in the brain's clock region were fewer than in freely fed rats.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP-immunoreactive neurons in the suprachiasmatic nucleus
    Study

    ratn: not reported in source

    Adult rats on timed hypocaloric food restriction for 7 months
    Comparator
    Free access to food
    Outcome group
    Circadian rhythm · Nervous system and cognition

    Source sentences

    Summary
    However, the total number of AVP- and VIP-immunoreactive neurons and the AVP and VIP mRNA levels were significantly decreased in timed hypocaloric food-restricted animals.
    1 context sentence
    Summary · context
    Two groups of adult rats, both maintained on 12-h light/12-h dark cycles, were used; in one group, animals had permanent free access to food, whereas in the other they were subjected to a restricted hypocaloric early morning feeding during 7 months.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adult rats, timed hypocaloric food restriction decreased VIP mRNA levels in the suprachiasmatic nucleus.

    In plain wordsIn rats on timed low-calorie feeding, the body's own VIP mRNA in the brain's clock region was lower than in freely fed rats.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP mRNA level in the suprachiasmatic nucleus
    Study

    ratn: not reported in source

    Adult rats on timed hypocaloric food restriction for 7 months
    Comparator
    Free access to food
    Outcome group
    Circadian rhythm · Nervous system and cognition

    Source sentences

    Summary
    However, the total number of AVP- and VIP-immunoreactive neurons and the AVP and VIP mRNA levels were significantly decreased in timed hypocaloric food-restricted animals.
    1 context sentence
    Summary · context
    Two groups of adult rats, both maintained on 12-h light/12-h dark cycles, were used; in one group, animals had permanent free access to food, whereas in the other they were subjected to a restricted hypocaloric early morning feeding during 7 months.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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