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Study · Animal study (in vivo) · rat · 2004

5 results

Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots: a comparison of intrathecal administration of brain-derived neurotrophic factor and Cerebrolysin.

Haninec P, Dubový P, Sámal F, Houstava L, Stejskal L

Experimental brain research4 Sept 2004Cited by 20 (Europe PMC)

PMID15351925 (opens in a new tab)DOI10.1007/s00221-004-1969-z (opens in a new tab)PepBankPUB-15351925
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ventral root avulsion, Cerebrolysin protected motor neurons against cell death.

    In plain wordsIn rats after nerve root injury, Cerebrolysin protected motor neurons from death.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMotor neuron death
    Study

    ratn: not reported in source

    C5 ventral root avulsion with nerve graft
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Cerebrolysin treatment greatly protected the motor neurons against cell death.
    1 context sentence
    Summary · context
    Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brain-derived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ventral root avulsion, Cerebrolysin improved myelinated axon morphometric features compared with vehicle.

    In plain wordsIn rats after nerve root injury, Cerebrolysin improved myelinated axon features compared with vehicle.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMyelinated axon morphometry versus vehicle
    Study

    ratn: not reported in source

    C5 ventral root avulsion with nerve graft
    Comparator
    vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Moreover, morphometric features of myelinated axons were better than those of rats treated with vehicle or BDNF.
    1 context sentence
    Summary · context
    Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brain-derived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ventral root avulsion, Cerebrolysin improved myelinated axon morphometric features compared with BDNF.

    In plain wordsIn rats after nerve root injury, Cerebrolysin improved myelinated axon features compared with BDNF.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMyelinated axon morphometry versus BDNF
    Study

    ratn: not reported in source

    C5 ventral root avulsion with nerve graft
    Comparator
    BDNF
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Moreover, morphometric features of myelinated axons were better than those of rats treated with vehicle or BDNF.
    1 context sentence
    Summary · context
    Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brain-derived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after ventral root avulsion, grooming scores suggested better motor reinnervation with Cerebrolysin than with BDNF.

    In plain wordsIn rats after nerve root injury, grooming scores suggested better motor recovery with Cerebrolysin than with BDNF.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGrooming test motor reinnervation
    Study

    ratn: not reported in source

    C5 ventral root avulsion with nerve graft
    Comparator
    BDNF
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    The mean score of grooming test suggested better results of the functional motor reinnervation than after BDNF administration.
    1 context sentence
    Summary · context
    Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brain-derived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In Cerebrolysin-treated rats, most rescued motor neurons regenerating axons through the graft expressed choline acetyltransferase immunostaining.

    In plain wordsIn rats given Cerebrolysin, most rescued motor neurons that regrew axons showed choline acetyltransferase staining.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableCholine acetyltransferase immunostaining
    Study

    ratn: not reported in source

    C5 ventral root avulsion with nerve graft
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    The majority of rescued motor neurons regenerating their axons through nerve graft in both BDNF- and Cerebrolysin-treated rats expressed choline acetyltransferase immunostaining.
    1 context sentence
    Summary · context
    Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brain-derived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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