Ageing and the diurnal expression of mRNAs for vasoactive intestinal peptide and for the VPAC2 and PAC1 receptors in the suprachiasmatic nucleus of male rats.

Kalló I, Kalamatianos T, Piggins HD, Coen CW

Journal of neuroendocrinology1 Sept 2004Cited by 43 (Europe PMC)

PMID15344914DOI10.1111/j.1365-2826.2004.01232.xPepBankPUB-15344914

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In aged male rats, VIP mRNA levels in the suprachiasmatic nucleus were lower than in young adult rats.
In plain wordsIn aged male rats, the body's own VIP mRNA in the brain's clock region was lower than in young adult rats.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP mRNA level in the suprachiasmatic nucleus
Study
ratn: not reported in source
Suprachiasmatic nucleus of young adult (2-3 months) and aged (19-20 months) male rats
Comparator
Young adult rats
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
Analysis of film autoradiographs from young adult (2-3 months) or aged (19-20 months) rats, at eight time points across the light/dark cycle, showed loss of diurnal rhythmicity and reduced levels for VIP mRNA in the aged group.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used isotopic in situ hybridization to examine the effects of ageing on expression of mRNAs for VIP, VPAC2 and PAC1 in the SCN of male rats under a 12 : 12 h light/dark cycle.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1534491401
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In aged male rats, the diurnal rhythm of VIP mRNA in the suprachiasmatic nucleus was lost, unlike in young adult rats.
In plain wordsIn aged male rats, the daily rhythm of the body's own VIP mRNA in the brain's clock region was lost.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseDiurnal rhythmicity of VIP mRNA in the suprachiasmatic nucleus
Study
ratn: not reported in source
Suprachiasmatic nucleus of young adult (2-3 months) and aged (19-20 months) male rats
Comparator
Young adult rats
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
Analysis of film autoradiographs from young adult (2-3 months) or aged (19-20 months) rats, at eight time points across the light/dark cycle, showed loss of diurnal rhythmicity and reduced levels for VIP mRNA in the aged group.
1 context sentence(design, population, supporting numbers)
Summary · context
This study used isotopic in situ hybridization to examine the effects of ageing on expression of mRNAs for VIP, VPAC2 and PAC1 in the SCN of male rats under a 12 : 12 h light/dark cycle.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1534491402

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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