Dizocilpine blocks the effects of delta sleep-inducing peptide-induced suppression of c-fos gene expression in the paraventricular nucleus of the hypothalamus in rats.

Umryukhin PE, Anokhin KV, Raevskii KS

Neuroscience and behavioral physiology1 Jun 2004Cited by 5 (Europe PMC)

PMID15330290DOI10.1023/b:neab.0000022637.57852.e0PepBankPUB-15330290

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, DSIP reduced c-fos gene expression in the paraventricular nucleus of the hypothalamus.
In plain wordsIn rats, DSIP lowered activity of the c-fos gene in a brain area called the paraventricular nucleus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Decreasec-fos expression in paraventricular nucleus
Study
ratn: not reported in source
c-fos expression in hypothalamic paraventricular nucleus
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
reductions in c-fos expression induced by delta sleep peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
The characteristics of the actions of the non-competitive blocker of NMDA receptors dizocilpine on the expression of the early c-fos gene in the paraventricular nuclei of the hypothalamus were studied in rats with different predicted susceptibilities to emotional stress in conditions of treatment wi…
Report a problemFND-1533029001

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism
In rats, prior treatment with the NMDA-receptor blocker dizocilpine blocked the DSIP-induced reduction in c-fos expression.
In plain wordsIn rats, the drug dizocilpine stopped DSIP from lowering c-fos gene activity in the brain.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseDizocilpine block of DSIP-induced c-fos reduction
Study
ratn: not reported in source
c-fos expression in hypothalamic paraventricular nucleus
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
The results showed that prior treatment with dizocilpine blocked reductions in c-fos expression induced by delta sleep peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
The characteristics of the actions of the non-competitive blocker of NMDA receptors dizocilpine on the expression of the early c-fos gene in the paraventricular nuclei of the hypothalamus were studied in rats with different predicted susceptibilities to emotional stress in conditions of treatment wi…
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1533029002

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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