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Study · Measured the body's own peptide · 2004

6 results

Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone-deficient lit/lit mice.

Iida K, Itoh E, Kim DS, del Rincon JP, Coschigano KT, Kopchick JJ, Thorner MO

The Journal of physiology12 Aug 2004Cited by 30 (Europe PMC)

PMID15308683 (opens in a new tab)DOI10.1113/jphysiol.2004.069500 (opens in a new tab)PepBankPUB-15308683
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mice that express bovine growth hormone, MGF mRNA in skeletal muscle was higher than in control animals.

    In plain wordsIn mice with extra growth hormone, the body's own MGF activity in muscle was higher than in control mice.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMuscle MGF mRNA in bGH transgenic mice
    Study

    mousen: not reported in source

    Comparator
    Control animals
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    MGF mRNA in skeletal muscle was increased in bGH mice whereas it was decreased in GHR-/- mice compared with control animals.
    1 context sentence
    Summary · context
    Therefore, we investigated the effect of chronic GH excess or disruption of GH receptor (GHR) signalling, and the acute effect of GH administration on expression of muscle IGF-I isoforms using transgenic mice that express bovine GH (bGH), GHR gene-disrupted (GHR-/-) mice and GH-deficient lit/lit mic…

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mice with a disrupted growth hormone receptor gene, MGF mRNA in skeletal muscle was lower than in control animals.

    In plain wordsIn mice without a working growth hormone receptor, the body's own MGF activity in muscle was lower than in control mice.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMuscle MGF mRNA in GHR-/- mice
    Study

    mousen: not reported in source

    Comparator
    Control animals
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    MGF mRNA in skeletal muscle was increased in bGH mice whereas it was decreased in GHR-/- mice compared with control animals.
    1 context sentence
    Summary · context
    Therefore, we investigated the effect of chronic GH excess or disruption of GH receptor (GHR) signalling, and the acute effect of GH administration on expression of muscle IGF-I isoforms using transgenic mice that express bovine GH (bGH), GHR gene-disrupted (GHR-/-) mice and GH-deficient lit/lit mic…

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In growth hormone deficient lit/lit mice, exogenous growth hormone increased muscle MGF mRNA 4 h after treatment, but not IGF-IEa mRNA.

    In plain wordsIn growth hormone deficient mice, a growth hormone dose raised the body's own MGF activity in muscle within 4 hours.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMuscle MGF mRNA in lit/lit mice, 4 h after GH
    Study

    mousen: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    Exogenous GH administration to dwarf lit/lit mice significantly increased muscle MGF but not IGF-IEa mRNA 4 h after treatment.
    1 context sentence
    Summary · context
    Therefore, we investigated the effect of chronic GH excess or disruption of GH receptor (GHR) signalling, and the acute effect of GH administration on expression of muscle IGF-I isoforms using transgenic mice that express bovine GH (bGH), GHR gene-disrupted (GHR-/-) mice and GH-deficient lit/lit mic…

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In growth hormone deficient lit/lit mice, muscle MGF mRNA was higher 12 h after growth hormone than in vehicle-treated mice.

    In plain wordsIn growth hormone deficient mice, the body's own MGF activity in muscle was higher 12 hours after growth hormone than with vehicle.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMuscle MGF mRNA in lit/lit mice, 12 h after GH
    Study

    mousen: not reported in source

    Comparator
    Vehicle-treated lit/lit mice
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    Twelve hours after GH treatment, both MGF and IGF-IEa mRNAs in muscle were increased compared with vehicle-treated lit/lit mice.
    1 context sentence
    Summary · context
    Therefore, we investigated the effect of chronic GH excess or disruption of GH receptor (GHR) signalling, and the acute effect of GH administration on expression of muscle IGF-I isoforms using transgenic mice that express bovine GH (bGH), GHR gene-disrupted (GHR-/-) mice and GH-deficient lit/lit mic…

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In GH-sufficient lit/+ mice, muscle MGF mRNA was increased 4 h after growth hormone treatment.

    In plain wordsIn mice with normal growth hormone, the body's own MGF activity in muscle rose 4 hours after growth hormone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMuscle MGF mRNA in lit/+ mice, 4 h after GH
    Study

    mousen: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    In contrast in GH-sufficient lit/+ mice, both MGF and IGF-IEa mRNAs were increased 4 h after and returned to the basal level 12 h after GH treatment.
    1 context sentence
    Summary · context
    Therefore, we investigated the effect of chronic GH excess or disruption of GH receptor (GHR) signalling, and the acute effect of GH administration on expression of muscle IGF-I isoforms using transgenic mice that express bovine GH (bGH), GHR gene-disrupted (GHR-/-) mice and GH-deficient lit/lit mic…

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  6. 06AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In GH-sufficient lit/+ mice, muscle MGF mRNA returned to the basal level 12 h after growth hormone treatment.

    In plain wordsIn mice with normal growth hormone, the body's own MGF activity in muscle was back to its starting level 12 hours after growth hormone.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMuscle MGF mRNA in lit/+ mice, 12 h after GH
    Study

    mousen: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    In contrast in GH-sufficient lit/+ mice, both MGF and IGF-IEa mRNAs were increased 4 h after and returned to the basal level 12 h after GH treatment.
    1 context sentence
    Summary · context
    Therefore, we investigated the effect of chronic GH excess or disruption of GH receptor (GHR) signalling, and the acute effect of GH administration on expression of muscle IGF-I isoforms using transgenic mice that express bovine GH (bGH), GHR gene-disrupted (GHR-/-) mice and GH-deficient lit/lit mic…

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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