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Study · Animal study (in vivo) · mouse · 2004

6 results

Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice.

De Winter BY, De Man JG, Seerden TC, Depoortere I, Herman AG, Peeters TL, Pelckmans PA

Neurogastroenterology and motility1 Aug 2004Cited by 77 (Europe PMC)

PMID15305999 (opens in a new tab)DOI10.1111/j.1365-2982.2004.00564.x (opens in a new tab)PepBankPUB-15305999
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In control mice, GHRP‑6 accelerated gastric emptying.

    In plain wordsIn mice, GHRP‑6 sped up emptying of the stomach.

    Peptide
    GHRP-6
    Outcome
    IncreaseGastric emptying in control mice
    Study

    mousen: not reported in source

    control mice
    Comparator
    Saline
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    20-100 microg kg(-1)As given in this study (mouse).

    Source sentences

    Summary
    In control mice, ghrelin (100 microg kg(-1)) and GHRP-6 (20-100 microg kg(-1)) accelerated gastric emptying, whereas ghrelin and GHRP-6 failed to increase transit significantly.
    2 context sentences
    Summary · context
    Mice were injected i.p. with lipopolysaccharides (LPS) or saline (control).
    Summary · context
    After 16-17 h mice were pretreated with saline, ghrelin or GHRP-6 1 h before intragastric administration of Evans blue.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In control mice, GHRP‑6 did not significantly increase gastric transit.

    In plain wordsIn mice, GHRP‑6 did not clearly speed up movement of food through the stomach.

    Peptide
    GHRP-6
    Outcome
    No significant changeGastric transit in control mice
    Study

    mousen: not reported in source

    control mice
    Comparator
    Saline
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    20-100 microg kg(-1)As given in this study (mouse).

    Source sentences

    Summary
    In control mice, ghrelin (100 microg kg(-1)) and GHRP-6 (20-100 microg kg(-1)) accelerated gastric emptying, whereas ghrelin and GHRP-6 failed to increase transit significantly.
    2 context sentences
    Summary · context
    Mice were injected i.p. with lipopolysaccharides (LPS) or saline (control).
    Summary · context
    After 16-17 h mice were pretreated with saline, ghrelin or GHRP-6 1 h before intragastric administration of Evans blue.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In septic mice, GHRP‑6 accelerated gastric emptying dose-dependently.

    In plain wordsIn mice with sepsis, GHRP‑6 sped up emptying of the stomach, more so at higher doses.

    Peptide
    GHRP-6
    Outcome
    IncreaseGastric emptying in septic mice
    Study

    mousen: not reported in source

    LPS-induced septic mice
    Comparator
    Saline
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In septic mice, ghrelin (20 microg kg(-1)) accelerated gastric emptying without effect on transit while GHRP-6 significantly accelerated gastric emptying dose-dependently and failed to increase transit significantly.
    2 context sentences
    Summary · context
    Mice were injected i.p. with lipopolysaccharides (LPS) or saline (control).
    Summary · context
    After 16-17 h mice were pretreated with saline, ghrelin or GHRP-6 1 h before intragastric administration of Evans blue.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In septic mice, GHRP‑6 did not significantly increase gastric transit.

    In plain wordsIn mice with sepsis, GHRP‑6 did not clearly speed up movement of food through the stomach.

    Peptide
    GHRP-6
    Outcome
    No significant changeGastric transit in septic mice
    Study

    mousen: not reported in source

    LPS-induced septic mice
    Comparator
    Saline
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In septic mice, ghrelin (20 microg kg(-1)) accelerated gastric emptying without effect on transit while GHRP-6 significantly accelerated gastric emptying dose-dependently and failed to increase transit significantly.
    2 context sentences
    Summary · context
    Mice were injected i.p. with lipopolysaccharides (LPS) or saline (control).
    Summary · context
    After 16-17 h mice were pretreated with saline, ghrelin or GHRP-6 1 h before intragastric administration of Evans blue.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In septic mice, GHRP‑6 had no effect on endotoxin-induced hypothermia.

    In plain wordsIn mice with sepsis, GHRP‑6 did not change the drop in body temperature.

    Peptide
    GHRP-6
    Outcome
    No significant changeEndotoxin-induced hypothermia
    Study

    mousen: not reported in source

    LPS-induced septic mice
    Comparator
    Saline
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ghrelin and GHRP-6 had no effect on the endotoxin-induced hypothermia or deterioration of behaviour scale.
    2 context sentences
    Summary · context
    Mice were injected i.p. with lipopolysaccharides (LPS) or saline (control).
    Summary · context
    After 16-17 h mice were pretreated with saline, ghrelin or GHRP-6 1 h before intragastric administration of Evans blue.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In septic mice, GHRP‑6 had no effect on the endotoxin-induced deterioration of the behaviour scale.

    In plain wordsIn mice with sepsis, GHRP‑6 did not improve the worsening of behaviour scores.

    Peptide
    GHRP-6
    Outcome
    No significant changeEndotoxin-induced deterioration of behaviour scale
    Study

    mousen: not reported in source

    LPS-induced septic mice
    Comparator
    Saline
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ghrelin and GHRP-6 had no effect on the endotoxin-induced hypothermia or deterioration of behaviour scale.
    2 context sentences
    Summary · context
    Mice were injected i.p. with lipopolysaccharides (LPS) or saline (control).
    Summary · context
    After 16-17 h mice were pretreated with saline, ghrelin or GHRP-6 1 h before intragastric administration of Evans blue.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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