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Study · Not a test of the peptide alone · 2004

2 results

Effect of recombinant porcine IGFBP-3 on IGF-I and long-R3-IGF-I-stimulated proliferation and differentiation of L6 myogenic cells.

Xi G, Kamanga-Sollo E, Pampusch MS, White ME, Hathaway MR, Dayton WR

Journal of cellular physiology1 Sept 2004Cited by 17 (Europe PMC)

PMID15254966 (opens in a new tab)DOI10.1002/jcp.20068 (opens in a new tab)PepBankPUB-15254966
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

  1. 01LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In L6 myogenic cells, recombinant porcine IGFBP-3 suppressed Long-R3-IGF-I-stimulated proliferation, which indicates IGF-independent suppression.

    In plain wordsIn cells, the binding protein IGFBP-3 reduced growth of muscle cells that Long-R3-IGF-I had stimulated. The agent tested was IGFBP-3.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseLong-R3-IGF-I-stimulated proliferation with rpIGFBP-3
    Study

    ratn: not reported in source

    L6 myogenic cell line
    Outcome group
    Cell proliferation and differentiation · Musculoskeletal

    Source sentences

    Summary
    RpIGFBP-3 suppresses both IGF-I and Long-R3-IGF-I-stimulated proliferation of L6 cells, indicating that it suppresses proliferation via both IGF-dependent and IGF-independent mechanisms.
    1 context sentence
    Summary · context
    In this study, we have examined the effects of recombinant porcine IGFBP-3 (rpIGFBP-3) on IGF-I- and Long-R3-IGF-I-stimulated proliferation and differentiation of the L6 myogenic cell line.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  2. 02LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In L6 myogenic cells, recombinant porcine IGFBP-3 did not suppress Long-R3-IGF-I-stimulated differentiation, unlike IGF-I-stimulated differentiation.

    In plain wordsIn cells, IGFBP-3 did not slow the maturing of muscle cells that Long-R3-IGF-I had stimulated. The agent tested was IGFBP-3.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeLong-R3-IGF-I-stimulated differentiation with rpIGFBP-3
    Study

    ratn: not reported in source

    L6 myogenic cell line
    Outcome group
    Cell proliferation and differentiation · Musculoskeletal

    Source sentences

    Summary
    In contrast, however, rpIGFBP-3 does not suppress Long-R3-IGF-I-stimulated differentiation.
    1 context sentence
    Summary · context
    In this study, we have examined the effects of recombinant porcine IGFBP-3 (rpIGFBP-3) on IGF-I- and Long-R3-IGF-I-stimulated proliferation and differentiation of the L6 myogenic cell line.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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