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Study · Ex vivo tissue · rat · 2004

2 results

Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain.

Hirasawa M, Schwab Y, Natah S, Hillard CJ, Mackie K, Sharkey KA, Pittman QJ

The Journal of physiology14 Jul 2004Cited by 99 (Europe PMC)

PMID15254151 (opens in a new tab)DOI10.1113/jphysiol.2004.066159 (opens in a new tab)PepBankPUB-15254151
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat supraoptic neurones, the CB1 antagonist AM251 blocked the presynaptic inhibition of EPSCs induced by oxytocin.

    In plain wordsIn rat brain cells, a drug that blocks cannabinoid CB1 receptors stopped oxytocin from damping nerve signals.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin-induced presynaptic inhibition blocked by CB1 antagonist AM251
    Study

    Ratn: not reported in source

    Supraoptic magnocellular neurones in rat brain
    Comparator
    AM251
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AM251, a CB1 receptor antagonist, blocked both the WIN55,212-2 and the oxytocin-induced presynaptic inhibition of EPSCs.
    1 context sentence
    Summary · context
    Oxytocin is released from supraoptic magnocellular neurones and is thought to act at presynaptic receptors to inhibit transmitter release.
  2. 02LabEx vivo tissueMechanism

    In rat supraoptic neurones, the cannabinoid agonist WIN55,212-2 mimicked the action of oxytocin and occluded oxytocin-induced presynaptic inhibition.

    In plain wordsIn rat brain cells, a cannabinoid drug copied oxytocin's damping of nerve signals and blocked further oxytocin effect.

    Peptide
    Oxytocin
    Outcome
    Not applicableCannabinoid agonist WIN55,212-2 mimicked and occluded oxytocin inhibition
    Study

    Ratn: not reported in source

    Supraoptic magnocellular neurones in rat brain
    Comparator
    WIN55,212-2
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    WIN55,212-2, a cannabinoid receptor agonist, mimicked the action of oxytocin and occluded oxytocin-induced presynaptic inhibition.
    1 context sentence
    Summary · context
    Oxytocin is released from supraoptic magnocellular neurones and is thought to act at presynaptic receptors to inhibit transmitter release.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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