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Study · Measured the body's own peptide · 2004

4 results

Alterations in the central vasopressin and oxytocin axis after lesion of a brain osmotic sensory region.

Oliveira GR, Franci CR, Rodovalho GV, Franci JA, Morris M, Rocha MJ

Brain research bulletin1 Jul 2004Cited by 12 (Europe PMC)

PMID15249117 (opens in a new tab)DOI10.1016/j.brainresbull.2004.04.009 (opens in a new tab)PepBankPUB-15249117
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, AV3V lesions were associated with higher oxytocin content in the supraoptic nucleus and the paraventricular nucleus.

    In plain wordsIn rats, a brain lesion went with more of the body's own oxytocin stored in two brain regions.

    Peptide
    Oxytocin
    Outcome
    IncreaseOT content in SON and PVN after AV3V lesion
    Study

    Ratn: not reported in source

    AV3V-lesioned rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    AV3V-lesioned rats exhibited an elevated plasma osmolality and higher OT content in SON and PVN.
    2 context sentences
    Summary · context
    The aim was to evaluate the effects of AV3V lesions on neurosecretion under control/water replete conditions and after 48 h dehydration.
    Summary · context
    The focus was on central peptidergic changes with measurement of OT and VP content in the hypothalamic paraventricular (PVN) and supraoptic (OT) regions and the posterior pituitary.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In AV3V-lesioned rats, the plasma oxytocin response to dehydration was absent.

    In plain wordsIn rats with the brain lesion, the body's own oxytocin in blood did not rise with dehydration.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma OT response to dehydration in lesioned rats
    Study

    Ratn: not reported in source

    AV3V-lesioned rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    As predicted, the plasma peptide response to dehydration was absent in lesioned animals.
    2 context sentences
    Summary · context
    The aim was to evaluate the effects of AV3V lesions on neurosecretion under control/water replete conditions and after 48 h dehydration.
    Summary · context
    The focus was on central peptidergic changes with measurement of OT and VP content in the hypothalamic paraventricular (PVN) and supraoptic (OT) regions and the posterior pituitary.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In AV3V-lesioned rats, dehydration produced no change in posterior pituitary oxytocin content.

    In plain wordsIn rats with the brain lesion, dehydration did not change the body's own oxytocin in the pituitary.

    Peptide
    Oxytocin
    Outcome
    No significant changePosterior pituitary OT after dehydration in lesioned rats
    Study

    Ratn: not reported in source

    AV3V-lesioned rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    with no change in OT.
    2 context sentences
    Summary · context
    The aim was to evaluate the effects of AV3V lesions on neurosecretion under control/water replete conditions and after 48 h dehydration.
    Summary · context
    The focus was on central peptidergic changes with measurement of OT and VP content in the hypothalamic paraventricular (PVN) and supraoptic (OT) regions and the posterior pituitary.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, dehydration caused no change in oxytocin levels in the hypothalamic nuclei.

    In plain wordsIn rats, dehydration did not change the body's own oxytocin levels in the brain nuclei.

    Peptide
    Oxytocin
    Outcome
    No significant changeNuclear OT levels after dehydration
    Study

    Ratn: not reported in source

    AV3V-lesioned rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    No changes in nuclear VP and OT levels were seen after dehydration.
    2 context sentences
    Summary · context
    The aim was to evaluate the effects of AV3V lesions on neurosecretion under control/water replete conditions and after 48 h dehydration.
    Summary · context
    The focus was on central peptidergic changes with measurement of OT and VP content in the hypothalamic paraventricular (PVN) and supraoptic (OT) regions and the posterior pituitary.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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