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Study · In vitro (cells) · 2004

2 results

Gonadotropin-releasing hormone initiates multiple signaling pathways in human GH-secreting adenomas.

Lania A, Mantovani G, Ferrante E, Zavanone LM, Locatelli M, Corbetta S, Beck-Peccoz P, Spada A

Journal of endocrinological investigation1 Apr 2004Cited by 7 (Europe PMC)

PMID15233551 (opens in a new tab)DOI10.1007/bf03351057 (opens in a new tab)PepBankPUB-15233551
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human GH-secreting adenoma cells, GHRP‑6 did not significantly modify cAMP levels.

    In plain wordsIn cells from human pituitary tumors, GHRP‑6 did not significantly change cAMP levels.

    Peptide
    GHRP-6
    Outcome
    No significant changecAMP levels
    Study

    humann: not reported in source

    Dispersed human GH-secreting adenoma cells responsive to GnRH
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these cells neither TRH nor GHRP-6 were effective in causing significant modifications of cAMP levels, despite their ability to increase [Ca2+]i.
    2 context sentences
    Summary · context
    GH-secreting adenomas removed from patients in vivo responsive to GnRH test were studied.
    Summary · context
    Intracellular calcium ([Ca2+]i) and cAMP levels were measured in dispersed cells and adenylyl cyclase (AC) activity in membrane preparations.
  2. 02LabIn vitro (cells)Mechanism

    In human GH-secreting adenoma cells, GHRP‑6 increased intracellular calcium.

    In plain wordsIn cells from human pituitary tumors, GHRP‑6 increased calcium inside the cells.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntracellular calcium
    Study

    humann: not reported in source

    Dispersed human GH-secreting adenoma cells responsive to GnRH
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these cells neither TRH nor GHRP-6 were effective in causing significant modifications of cAMP levels, despite their ability to increase [Ca2+]i.
    2 context sentences
    Summary · context
    GH-secreting adenomas removed from patients in vivo responsive to GnRH test were studied.
    Summary · context
    Intracellular calcium ([Ca2+]i) and cAMP levels were measured in dispersed cells and adenylyl cyclase (AC) activity in membrane preparations.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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