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Study · Animal study (in vivo) · rat · 2004

10 results

Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression.

Li G, Zhang Y, Wilsey JT, Scarpace PJ

The Journal of endocrinology1 Jul 2004Cited by 39 (Europe PMC)

PMID15225137 (opens in a new tab)DOI10.1677/joe.0.1820123 (opens in a new tab)PepBankPUB-15225137
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In chow-fed and diet-induced obese rats, six-day central melanotan II infusion reduced body weight compared with ad libitum-fed control and pair-fed groups.

    In plain wordsIn rats, melanotan II infused into the brain lowered body weight compared with free-fed and pair-fed rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight
    Study

    ratn: not reported in source

    Chow-fed and high-fat diet-induced obese Sprague-Dawley rats
    Comparator
    Ad libitum-fed control and pair-fed groups
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    Six-day central infusion of MTII (1 nmol/day) reduced body weight and visceral adiposity compared with ad libitum-fed control and pair-fed groups and markedly suppressed caloric intake in both CH and DIO rats.
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In chow-fed and diet-induced obese rats, six-day central melanotan II infusion reduced visceral adiposity compared with ad libitum-fed control and pair-fed groups.

    In plain wordsIn rats, melanotan II infused into the brain lowered belly fat compared with free-fed and pair-fed rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseVisceral adiposity
    Study

    ratn: not reported in source

    Chow-fed and high-fat diet-induced obese Sprague-Dawley rats
    Comparator
    Ad libitum-fed control and pair-fed groups
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    Six-day central infusion of MTII (1 nmol/day) reduced body weight and visceral adiposity compared with ad libitum-fed control and pair-fed groups and markedly suppressed caloric intake in both CH and DIO rats.
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In chow-fed and diet-induced obese rats, central melanotan II markedly suppressed caloric intake.

    In plain wordsIn rats, melanotan II infused into the brain strongly reduced the calories eaten.

    Peptide
    Melanotan II
    Outcome
    DecreaseCaloric intake
    Study

    ratn: not reported in source

    Chow-fed and high-fat diet-induced obese Sprague-Dawley rats
    Comparator
    Ad libitum-fed control and pair-fed groups
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    Six-day central infusion of MTII (1 nmol/day) reduced body weight and visceral adiposity compared with ad libitum-fed control and pair-fed groups and markedly suppressed caloric intake in both CH and DIO rats.
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    The reduction in food intake with melanotan II was similar in diet-induced obese rats and chow-fed rats.

    In plain wordsIn rats, melanotan II cut food intake about equally in obese rats and chow-fed rats.

    Peptide
    Melanotan II
    Outcome
    No significant changeAnorexic response in diet-induced obese versus chow-fed rats
    Study

    ratn: not reported in source

    Chow-fed and high-fat diet-induced obese Sprague-Dawley rats
    Comparator
    Chow-fed rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    The anorexic response to MTII was similar in DIO relative to CH rats.
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    Melanotan II induced a sustained increase in oxygen consumption in diet-induced obese rats and a delayed response in chow-fed rats.

    In plain wordsIn rats, melanotan II raised oxygen use steadily in obese rats and with a delay in chow-fed rats.

    Peptide
    Melanotan II
    Outcome
    IncreaseOxygen consumption
    Study

    ratn: not reported in source

    Chow-fed and high-fat diet-induced obese Sprague-Dawley rats
    Comparator
    Chow-fed rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    MTII induced a sustained increase in oxygen consumption in DIO but a delayed response in CH rats.
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In both chow-fed and diet-induced obese rats, melanotan II reduced serum insulin compared with controls.

    In plain wordsIn rats on either diet, melanotan II lowered blood insulin compared with controls.

    Peptide
    Melanotan II
    Outcome
    DecreaseSerum insulin
    Study

    ratn: not reported in source

    Chow-fed and high-fat diet-induced obese Sprague-Dawley rats
    Comparator
    Controls
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    In both diet groups, MTII reduced serum insulin and cholesterol levels compared with controls.
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In both chow-fed and diet-induced obese rats, melanotan II reduced serum cholesterol compared with controls.

    In plain wordsIn rats on either diet, melanotan II lowered blood cholesterol compared with controls.

    Peptide
    Melanotan II
    Outcome
    DecreaseSerum cholesterol
    Study

    ratn: not reported in source

    Chow-fed and high-fat diet-induced obese Sprague-Dawley rats
    Comparator
    Controls
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    In both diet groups, MTII reduced serum insulin and cholesterol levels compared with controls.
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In chow-fed and diet-induced obese rats, melanotan II further elevated uncoupling protein 1 levels in brown adipose tissue.

    In plain wordsIn rats, melanotan II raised levels of a heat-producing protein (UCP1) in brown fat.

    Peptide
    Melanotan II
    Outcome
    IncreaseBrown adipose tissue UCP1
    Study

    ratn: not reported in source

    Chow-fed and high-fat diet-induced obese Sprague-Dawley rats
    Comparator
    Untreated rats on the same diet
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    UCP1 levels were further elevated in MTII-treated CH and DIO rats.
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In diet-induced obese rats, melanotan II lowered acetyl-CoA carboxylase expression in muscle.

    In plain wordsIn obese rats, melanotan II lowered activity of a fat-making enzyme gene in muscle.

    Peptide
    Melanotan II
    Outcome
    DecreaseMuscle acetyl-CoA carboxylase expression
    Study

    ratn: not reported in source

    High-fat diet-induced obese Sprague-Dawley rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    MTII lowered acetyl-CoA carboxylase expression
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In diet-induced obese rats, melanotan II prevented the reduction in muscle carnitine palmitoyltransferase I mRNA seen with pair-feeding.

    In plain wordsIn obese rats, melanotan II prevented a drop in a fat-burning enzyme gene in muscle that pair-feeding caused.

    Peptide
    Melanotan II
    Outcome
    IncreaseMuscle-type carnitine palmitoyltransferase I mRNA
    Study

    ratn: not reported in source

    Chow-fed and high-fat diet-induced obese Sprague-Dawley rats
    Comparator
    Pair-fed rats
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    1 nmol/day · central infusion · 6 daysAs given in this study (rat).

    Source sentences

    Summary
    MTII lowered acetyl-CoA carboxylase expression and prevented the reduction in muscle-type carnitine palmitoyltransferase I mRNA by pair-feeding in the muscle of DIO rats.
    1 context sentence
    Summary · context
    The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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