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Study · Animal study (in vivo) · mouse · 2004

4 results

Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice.

Amico JA, Vollmer RR, Karam JR, Lee PR, Li X, Koenig JI, McCarthy MM

Pharmacology, biochemistry, and behavior1 Jun 2004Cited by 37 (Europe PMC)

PMID15219775 (opens in a new tab)DOI10.1016/j.pbb.2004.04.006 (opens in a new tab)PepBankPUB-15219775
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In oxytocin null and wild-type mice, intracerebroventricular oxytocin, but not vehicle, produced a robust increase in grooming behavior.

    In plain wordsIn mice, oxytocin injected into the brain ventricles increased grooming; the vehicle did not.

    Peptide
    Oxytocin
    Outcome
    IncreaseGrooming after intracerebroventricular oxytocin
    Study

    mousen: not reported in source

    Oxytocin null and wild-type mice
    Comparator
    Vehicle (artificial cerebrospinal fluid)
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    The intracerebroventricular administration of OT, but not vehicle, artificial cerebrospinal fluid (aCSF), produced a robust increase in grooming behavior in both OT null and wild type animals, P<.001.
    2 context sentences
    Summary · context
    Experiments were conducted to determine if the chronic absence of the neurotransmitter oxytocin (OT) in null mice resulted in alterations in the responsiveness and abundance of central OT receptors.
    Summary · context
    Self-grooming elicited by intracerebroventricularly administered OT was studied as an indicator of the activation of central OT receptors and autoradiography was used to map the distribution and density of OT receptors in OT null and wild type mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, oxytocin-induced grooming was significantly greater in oxytocin null mice than in wild-type mice.

    In plain wordsIn mice, oxytocin triggered more grooming in mice lacking oxytocin than in normal mice.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin-induced grooming, null versus wild-type mice
    Study

    mousen: not reported in source

    Oxytocin null and wild-type mice
    Comparator
    Wild-type mice
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    However, OT-induced grooming was significantly greater in OT null than wild type mice, P<.005.
    2 context sentences
    Summary · context
    Experiments were conducted to determine if the chronic absence of the neurotransmitter oxytocin (OT) in null mice resulted in alterations in the responsiveness and abundance of central OT receptors.
    Summary · context
    Self-grooming elicited by intracerebroventricularly administered OT was studied as an indicator of the activation of central OT receptors and autoradiography was used to map the distribution and density of OT receptors in OT null and wild type mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, pretreatment with the oxytocin antagonist atosiban abolished oxytocin-induced grooming.

    In plain wordsIn mice, the oxytocin blocker atosiban stopped the grooming that oxytocin caused.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-induced grooming with atosiban pretreatment
    Study

    mousen: not reported in source

    Oxytocin null and wild-type mice
    Comparator
    Atosiban
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    pretreatment of animals with an OT antagonist, Atosiban, abolished OT-induced grooming, but not AVP-induced grooming.
    2 context sentences
    Summary · context
    Experiments were conducted to determine if the chronic absence of the neurotransmitter oxytocin (OT) in null mice resulted in alterations in the responsiveness and abundance of central OT receptors.
    Summary · context
    Self-grooming elicited by intracerebroventricularly administered OT was studied as an indicator of the activation of central OT receptors and autoradiography was used to map the distribution and density of OT receptors in OT null and wild type mice.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In mice, oxytocin receptor distribution and binding by autoradiography did not differ significantly between oxytocin null and wild-type brains.

    In plain wordsIn mice, the number and location of oxytocin receptors in the brain were not clearly different between mice lacking oxytocin and normal mice.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin receptor distribution and binding
    Study

    mousen: not reported in source

    Oxytocin null and wild-type mice
    Comparator
    Wild-type mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    OT receptor distribution and binding in brains of OT null and wild type mice were examined by autoradiography and were not significantly different.
    2 context sentences
    Summary · context
    Experiments were conducted to determine if the chronic absence of the neurotransmitter oxytocin (OT) in null mice resulted in alterations in the responsiveness and abundance of central OT receptors.
    Summary · context
    Self-grooming elicited by intracerebroventricularly administered OT was studied as an indicator of the activation of central OT receptors and autoradiography was used to map the distribution and density of OT receptors in OT null and wild type mice.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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