Skip to content

Study · Animal study (in vivo) · mouse · 2004

4 results

Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis.

Perrin C, Knauf C, Burcelin R

Endocrinology10 Jun 2004Cited by 62 (Europe PMC)

PMID15192044 (opens in a new tab)DOI10.1210/en.2004-0270 (opens in a new tab)PepBankPUB-15192044
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice during a hyperinsulinemic clamp, cerebral AICAR infusion increased insulin-stimulated muscle glycogen synthesis.

    In plain wordsIn mice during an insulin clamp, brain AICAR infusion increased insulin-stimulated muscle glycogen production.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseInsulin-stimulated muscle glycogen synthesis
    Study

    mousen: not reported in source

    mouse cerebral infusion model
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    We show in this study that the intracerebroventricular infusion of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), a pharmacological AMP-activated kinase activator, increased insulin-stimulated muscle glycogen synthesis and insulin sensitivity during a hyperinsulinemic clamp.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice during a hyperinsulinemic clamp, cerebral AICAR infusion increased insulin sensitivity.

    In plain wordsIn mice during an insulin clamp, brain AICAR infusion increased insulin sensitivity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseInsulin sensitivity during clamp
    Study

    mousen: not reported in source

    mouse cerebral infusion model
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    We show in this study that the intracerebroventricular infusion of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), a pharmacological AMP-activated kinase activator, increased insulin-stimulated muscle glycogen synthesis and insulin sensitivity during a hyperinsulinemic clamp.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In fasted mice with low insulinemia, brain AICAR infusion increased muscle glycogen synthesis.

    In plain wordsIn fasted mice with low insulin, brain AICAR infusion increased muscle glycogen production.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMuscle glycogen synthesis during fasting
    Study

    mousen: not reported in source

    mouse cerebral infusion model
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Similarly, we infused AICAR in the brain of fasted mice, i.e. when insulinemia was low, and showed that muscle glycogen synthesis was also increased.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, cerebral AICAR injections were associated with variations in hypothalamic AMPK phosphorylation without a reported direction.

    In plain wordsIn mice, brain AICAR injections were linked to changes in hypothalamic AMPK phosphorylation, with no stated direction.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedHypothalamic AMPK phosphorylation
    Study

    mousen: not reported in source

    mouse cerebral infusion model
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Importantly, the cerebral injections of AICAR, insulin, and glucose were associated with variations in the phosphorylation state of the AMP-activated kinase in the hypothalamus.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.