Glucocorticoid-dependent stimulation of adiposity and appetite by a ghrelin mimetic in the rat.

Tung YL, Hewson AK, Dickson SL

European journal of endocrinology1 Jun 2004Cited by 13 (Europe PMC)

PMID15191362DOI10.1530/eje.0.1500905PepBankPUB-15191362

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In adrenal-intact and adrenalectomised rats, GHRP‑6 increased body weight compared with saline controls.
In plain wordsIn rats with and without adrenal glands, GHRP‑6 increased body weight compared with saline.
Peptide
GHRP-6
Outcome
IncreaseBody weight
Study
ratn: not reported in source
Adrenal-intact or adrenalectomised rats
Comparator
Saline controls
Outcome group
Body weight · Metabolic and weight
Studied dose
250 microg/kg twice daily · subcutaneous · 2 weeksAs given in this study (rat).
Source sentences
Summary
All GHS-injected rats had a significantly increased body weight at the end of 2 weeks of treatment compared with saline controls.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250 microg/kg) for 2 weeks on body weight, food intake and fat pad weight were determined in both adrenalectomised (ADX) rats (with or without basal corticosterone replacement) and adrenal-intact rats.
Report a problemFND-1519136201
02AnimalAnimal study (in vivo)Efficacy outcome
In adrenal-intact rats, GHRP‑6 increased subcutaneous inguinal fat pad weight by 15% versus saline controls.
In plain wordsIn rats with adrenal glands, GHRP‑6 increased groin fat pad weight compared with saline.
Peptide
GHRP-6
Outcome
IncreaseSubcutaneous inguinal fat pad weight
Study
ratn: not reported in source
Adrenal-intact rats
Comparator
Saline controls
Outcome group
Body composition · Metabolic and weight
Studied dose
250 microg/kg twice daily · subcutaneous · 2 weeksAs given in this study (rat).
Measurements
Inguinal fat pad weight increase
15%
Adrenal-intact rats versus saline
Source sentences
Summary
However, increased fat accumulation was only seen in adrenal-intact rats, with a 15% increase in s.c. inguinal (P<0.05 vs saline controls) and 20% increase in visceral mesenteric (P<0.05) fat pad weights following GHS treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250 microg/kg) for 2 weeks on body weight, food intake and fat pad weight were determined in both adrenalectomised (ADX) rats (with or without basal corticosterone replacement) and adrenal-intact rats.
Report a problemFND-1519136202
03AnimalAnimal study (in vivo)Efficacy outcome
In adrenal-intact rats, GHRP‑6 increased visceral mesenteric fat pad weight by 20% versus saline controls.
In plain wordsIn rats with adrenal glands, GHRP‑6 increased fat pad weight around the intestines compared with saline.
Peptide
GHRP-6
Outcome
IncreaseVisceral mesenteric fat pad weight
Study
ratn: not reported in source
Adrenal-intact rats
Comparator
Saline controls
Outcome group
Body composition · Metabolic and weight
Studied dose
250 microg/kg twice daily · subcutaneous · 2 weeksAs given in this study (rat).
Measurements
Mesenteric fat pad weight increase
20%
Adrenal-intact rats versus saline
Source sentences
Summary
However, increased fat accumulation was only seen in adrenal-intact rats, with a 15% increase in s.c. inguinal (P<0.05 vs saline controls) and 20% increase in visceral mesenteric (P<0.05) fat pad weights following GHS treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250 microg/kg) for 2 weeks on body weight, food intake and fat pad weight were determined in both adrenalectomised (ADX) rats (with or without basal corticosterone replacement) and adrenal-intact rats.
Report a problemFND-1519136203
04AnimalAnimal study (in vivo)Efficacy outcome
In adrenalectomised rats, increased body weight after GHRP‑6 did not reflect increased fat mass.
In plain wordsIn rats without adrenal glands, GHRP‑6-related weight gain did not reflect increased fat mass.
Peptide
GHRP-6
Outcome
No significant changeFat mass in adrenalectomised rats
Study
ratn: not reported in source
Adrenalectomised rats
Comparator
Saline controls
Outcome group
Body composition · Metabolic and weight
Studied dose
250 microg/kg twice daily · subcutaneous · 2 weeksAs given in this study (rat).
Source sentences
Summary
The increased body weight observed in ADX rats following GHS treatment was not due to increased fat mass or increased weight of other organs measured.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250 microg/kg) for 2 weeks on body weight, food intake and fat pad weight were determined in both adrenalectomised (ADX) rats (with or without basal corticosterone replacement) and adrenal-intact rats.
Report a problemFND-1519136204
05AnimalAnimal study (in vivo)Efficacy outcome
In adrenalectomised rats, increased body weight after GHRP‑6 did not reflect increased weights of other measured organs.
In plain wordsIn rats without adrenal glands, GHRP‑6-related weight gain did not reflect increased weights of other measured organs.
Peptide
GHRP-6
Outcome
No significant changeOther measured organ weights in adrenalectomised rats
Study
ratn: not reported in source
Adrenalectomised rats
Comparator
Saline controls
Outcome group
Body composition · Metabolic and weight
Studied dose
250 microg/kg twice daily · subcutaneous · 2 weeksAs given in this study (rat).
Source sentences
Summary
The increased body weight observed in ADX rats following GHS treatment was not due to increased fat mass or increased weight of other organs measured.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250 microg/kg) for 2 weeks on body weight, food intake and fat pad weight were determined in both adrenalectomised (ADX) rats (with or without basal corticosterone replacement) and adrenal-intact rats.
Report a problemFND-1519136205
06AnimalAnimal study (in vivo)Efficacy outcome
In adrenal-intact rats, a single GHRP‑6 injection increased food intake for up to 7 h.
In plain wordsIn rats with adrenal glands, one GHRP‑6 injection increased food intake compared with saline.
Peptide
GHRP-6
Outcome
IncreaseFood intake in adrenal-intact rats
Study
ratn: not reported in source
Adrenal-intact rats
Comparator
Saline controls
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · subcutaneous · up to 7 hAs given in this study (rat).
Source sentences
Summary
Food intake was increased for up to 7 h following a single injection of GHRP-6 in both the adrenal-intact (P<0.01) and corticosterone-replacement groups (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250 microg/kg) for 2 weeks on body weight, food intake and fat pad weight were determined in both adrenalectomised (ADX) rats (with or without basal corticosterone replacement) and adrenal-intact rats.
Report a problemFND-1519136206
07AnimalAnimal study (in vivo)Efficacy outcome
In corticosterone-replaced adrenalectomised rats, a single GHRP‑6 injection increased food intake for up to 7 h.
In plain wordsIn rats without adrenal glands that received corticosterone replacement, GHRP‑6 increased food intake compared with saline.
Peptide
GHRP-6
Outcome
IncreaseFood intake with corticosterone replacement
Study
ratn: not reported in source
Adrenalectomised rats with basal corticosterone replacement
Comparator
Saline controls
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · subcutaneous · up to 7 hAs given in this study (rat).
Source sentences
Summary
Food intake was increased for up to 7 h following a single injection of GHRP-6 in both the adrenal-intact (P<0.01) and corticosterone-replacement groups (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250 microg/kg) for 2 weeks on body weight, food intake and fat pad weight were determined in both adrenalectomised (ADX) rats (with or without basal corticosterone replacement) and adrenal-intact rats.
Report a problemFND-1519136207
08AnimalAnimal study (in vivo)Efficacy outcome
In adrenalectomised rats without corticosterone replacement, GHRP‑6 did not stimulate food intake at any measured time.
In plain wordsIn rats without adrenal glands or corticosterone replacement, GHRP‑6 did not increase food intake compared with saline.
Peptide
GHRP-6
Outcome
No significant changeFood intake without corticosterone replacement
Study
ratn: not reported in source
Adrenalectomised rats without corticosterone replacement
Comparator
Saline controls
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
This stimulating effect on food intake was not observed at any time point in the ADX rats without corticosterone replacement.
2 context sentences(design, population, supporting numbers)
Summary · context
Food intake was increased for up to 7 h following a single injection of GHRP-6 in both the adrenal-intact (P<0.01) and corticosterone-replacement groups (P<0.05).
Summary · context
The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250 microg/kg) for 2 weeks on body weight, food intake and fat pad weight were determined in both adrenalectomised (ADX) rats (with or without basal corticosterone replacement) and adrenal-intact rats.
Report a problemFND-1519136208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.