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Study · Measured the body's own peptide · 2004

4 results

Interaction of prolactin, ANPergic, oxytocinergic and adrenal systems in response to extracellular volume expansion in rats.

Durlo FV, Castro M, Elias LL, Antunes-Rodrigues J

Experimental physiology7 Jun 2004Cited by 31 (Europe PMC)

PMID15184358 (opens in a new tab)DOI10.1113/expphysiol.2004.027243 (opens in a new tab)PepBankPUB-15184358
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In control rats, isotonic and hypertonic extracellular volume expansion significantly increased plasma oxytocin concentrations.

    In plain wordsIn rats, the body's own oxytocin levels in blood rose after saline injections that expanded blood volume.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after isotonic and hypertonic volume expansion
    Study

    ratn: not reported in source

    Male Wistar rats, extracellular volume expansion
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    After isotonic and hypertonic EVE, the control group showed a significant increase in the plasma concentrations of prolactin, corticosterone, ANP and oxytocin.
    2 context sentences
    Summary · context
    The present study evaluated the effect of acute extracellular volume expansion (EVE) induced by intravenous injection of isotonic (0.15 m NaCl) or hypertonic saline (0.3 m NaCl) on prolactin, corticosterone, vasopressin, oxytocin and atrial natriuretic peptide (ANP) secretion.
    Summary · context
    Male Wistar rats were treated with bromocriptine, sulpiride or dexamethasone.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, the rise in plasma oxytocin was more pronounced after hypertonic than after isotonic volume expansion.

    In plain wordsIn rats, the body's own oxytocin rose more after salty saline than after normal saline.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin, hypertonic versus isotonic expansion
    Study

    ratn: not reported in source

    Male Wistar rats, extracellular volume expansion
    Comparator
    Isotonic volume expansion
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The increase in ANP and oxytocin levels in response to hypertonic EVE was more pronounced than to isotonic EVE.
    2 context sentences
    Summary · context
    The present study evaluated the effect of acute extracellular volume expansion (EVE) induced by intravenous injection of isotonic (0.15 m NaCl) or hypertonic saline (0.3 m NaCl) on prolactin, corticosterone, vasopressin, oxytocin and atrial natriuretic peptide (ANP) secretion.
    Summary · context
    Male Wistar rats were treated with bromocriptine, sulpiride or dexamethasone.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, bromocriptine and sulpiride treatments did not modify the plasma oxytocin response to isotonic or hypertonic volume expansion.

    In plain wordsIn rats, two prolactin-acting drugs did not change the body's own oxytocin rise after volume expansion.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin response with bromocriptine or sulpiride
    Study

    ratn: not reported in source

    Male Wistar rats, extracellular volume expansion
    Comparator
    Untreated control rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Bromocriptine and sulpiride treatments did not modify corticosterone, ANP and oxytocin responses to either isotonic or hypertonic EVE.
    2 context sentences
    Summary · context
    The present study evaluated the effect of acute extracellular volume expansion (EVE) induced by intravenous injection of isotonic (0.15 m NaCl) or hypertonic saline (0.3 m NaCl) on prolactin, corticosterone, vasopressin, oxytocin and atrial natriuretic peptide (ANP) secretion.
    Summary · context
    Male Wistar rats were treated with bromocriptine, sulpiride or dexamethasone.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, dexamethasone pretreatment blocked the rise in plasma oxytocin after volume expansion.

    In plain wordsIn rats, dexamethasone pretreatment blocked the rise in the body's own oxytocin after volume expansion.

    Peptide
    Oxytocin
    Outcome
    DecreasePlasma oxytocin response with dexamethasone pretreatment
    Study

    ratn: not reported in source

    Male Wistar rats, extracellular volume expansion
    Comparator
    Untreated control rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The increases in prolactin and oxytocin, but not ANP, were blocked in dexamethasone pretreated rats.
    2 context sentences
    Summary · context
    The present study evaluated the effect of acute extracellular volume expansion (EVE) induced by intravenous injection of isotonic (0.15 m NaCl) or hypertonic saline (0.3 m NaCl) on prolactin, corticosterone, vasopressin, oxytocin and atrial natriuretic peptide (ANP) secretion.
    Summary · context
    Male Wistar rats were treated with bromocriptine, sulpiride or dexamethasone.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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