Stress-induced pressor and corticosterone responses in oxytocin-deficient mice.

Bernatova I, Rigatto KV, Key MP, Morris M

Experimental physiology7 Jun 2004Cited by 38 (Europe PMC)

PMID15184356DOI10.1113/expphysiol.2004.027714PepBankPUB-15184356

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In mice, oxytocin deficiency was linked to lower 24 h average mean arterial pressure than in wild-type controls.
In plain wordsIn mice lacking oxytocin, average blood pressure over 24 hours was lower than in normal mice.
Peptide
Oxytocin
Outcome
Decrease24 h average mean arterial pressure
Study
mousen: not reported in source
Oxytocin knockout mice
Comparator
Wild-type controls
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
Twenty-four hour averages of MAP and HR were lower in OTKO mice than in controls (P < 0.0001 and P < 0.005, respectively) with a significant diurnal rhythm.
2 context sentences(design, population, supporting numbers)
Summary · context
We used oxytocin knockout (OTKO) mice to investigate the role of oxytocin in regulation of blood pressure, heart rate and stress reactivity (pressure reactivity and plasma corticosterone).
Summary · context
Male OTKO and control wild-type mice with carotid arterial catheters were exposed to intermittent shaker stress for 7 days (2 min stressors, 45 times per day).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1518435601
02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In mice, oxytocin deficiency was linked to lower 24 h average heart rate than in wild-type controls.
In plain wordsIn mice lacking oxytocin, average heart rate over 24 hours was lower than in normal mice.
Peptide
Oxytocin
Outcome
Decrease24 h average heart rate
Study
mousen: not reported in source
Oxytocin knockout mice
Comparator
Wild-type controls
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Twenty-four hour averages of MAP and HR were lower in OTKO mice than in controls (P < 0.0001 and P < 0.005, respectively) with a significant diurnal rhythm.
2 context sentences(design, population, supporting numbers)
Summary · context
We used oxytocin knockout (OTKO) mice to investigate the role of oxytocin in regulation of blood pressure, heart rate and stress reactivity (pressure reactivity and plasma corticosterone).
Summary · context
Male OTKO and control wild-type mice with carotid arterial catheters were exposed to intermittent shaker stress for 7 days (2 min stressors, 45 times per day).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1518435602
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In oxytocin knockout mice, chronic stress on days 1 and 3 increased 24 h average mean arterial pressure, whereas controls showed no increase.
In plain wordsIn mice lacking oxytocin, repeated stress raised average blood pressure; in normal mice it did not.
Peptide
Oxytocin
Outcome
Increase24 h MAP during chronic stress (days 1 and 3)
Study
mousen: not reported in source
Oxytocin knockout mice
Comparator
Wild-type controls
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
Chronic stress (S1 and S3) produced an increase in 24 h average MAP in OTKO mice, but not in controls.
2 context sentences(design, population, supporting numbers)
Summary · context
We used oxytocin knockout (OTKO) mice to investigate the role of oxytocin in regulation of blood pressure, heart rate and stress reactivity (pressure reactivity and plasma corticosterone).
Summary · context
Male OTKO and control wild-type mice with carotid arterial catheters were exposed to intermittent shaker stress for 7 days (2 min stressors, 45 times per day).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1518435603
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In mice, there were no stress-related changes in 24 h average heart rate between control and oxytocin knockout mice.
In plain wordsIn mice, repeated stress did not change average heart rate differently in mice lacking oxytocin and normal mice.
Peptide
Oxytocin
Outcome
No significant change24 h average heart rate during chronic stress
Study
mousen: not reported in source
Oxytocin knockout mice
Comparator
Wild-type controls
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
There were no stress-related changes in 24 h average HR values between control and OTKO mice.
2 context sentences(design, population, supporting numbers)
Summary · context
We used oxytocin knockout (OTKO) mice to investigate the role of oxytocin in regulation of blood pressure, heart rate and stress reactivity (pressure reactivity and plasma corticosterone).
Summary · context
Male OTKO and control wild-type mice with carotid arterial catheters were exposed to intermittent shaker stress for 7 days (2 min stressors, 45 times per day).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1518435604
05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In mice, stress-induced pressor responses in the dark period were seen only in oxytocin knockout mice, on stress days 1 and 3.
In plain wordsIn mice lacking oxytocin, stress raised blood pressure in the dark period; in normal mice it did not.
Peptide
Oxytocin
Outcome
IncreaseImmediate pressor response in the dark period
Study
mousen: not reported in source
Oxytocin knockout mice
Comparator
Wild-type controls
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
During the dark period, stress-induced pressor responses were observed only in OTKO mice (S1 and S3).
2 context sentences(design, population, supporting numbers)
Summary · context
We used oxytocin knockout (OTKO) mice to investigate the role of oxytocin in regulation of blood pressure, heart rate and stress reactivity (pressure reactivity and plasma corticosterone).
Summary · context
Male OTKO and control wild-type mice with carotid arterial catheters were exposed to intermittent shaker stress for 7 days (2 min stressors, 45 times per day).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1518435605
06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In mice, stress-induced rises in mean arterial pressure in the light period occurred on all days in oxytocin knockout mice and on days 1 and 3 in controls.
In plain wordsIn mice, stress raised blood pressure in the light period on all days in mice lacking oxytocin, and on fewer days in normal mice.
Peptide
Oxytocin
Outcome
MixedImmediate pressor response in the light period
Study
mousen: not reported in source
Oxytocin knockout mice
Comparator
Wild-type controls
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
In the light period, stress-induced MAP increases were seen on all days in OTKO mice and on days S1 and S3 in controls.
2 context sentences(design, population, supporting numbers)
Summary · context
We used oxytocin knockout (OTKO) mice to investigate the role of oxytocin in regulation of blood pressure, heart rate and stress reactivity (pressure reactivity and plasma corticosterone).
Summary · context
Male OTKO and control wild-type mice with carotid arterial catheters were exposed to intermittent shaker stress for 7 days (2 min stressors, 45 times per day).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1518435606
07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In mice, baseline plasma corticosterone did not differ between oxytocin knockout mice and controls.
In plain wordsIn mice, resting stress-hormone levels were the same in mice lacking oxytocin and in normal mice.
Peptide
Oxytocin
Outcome
No significant changeBaseline plasma corticosterone
Study
mousen: not reported in source
Oxytocin knockout mice
Comparator
Wild-type controls
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
There were no differences in baseline Cort between the groups; however, OTKO mice showed a reduced response to chronic stress (+298 versus+411%, OTKO mice versus controls, P < 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
We used oxytocin knockout (OTKO) mice to investigate the role of oxytocin in regulation of blood pressure, heart rate and stress reactivity (pressure reactivity and plasma corticosterone).
Summary · context
Male OTKO and control wild-type mice with carotid arterial catheters were exposed to intermittent shaker stress for 7 days (2 min stressors, 45 times per day).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1518435607
08AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In mice, oxytocin knockout mice showed a reduced corticosterone response to chronic stress (+298 versus +411%) compared with controls.
In plain wordsIn mice lacking oxytocin, the stress-hormone rise after repeated stress was smaller than in normal mice.
Peptide
Oxytocin
Outcome
DecreaseCorticosterone response to chronic stress
Study
mousen: not reported in source
Oxytocin knockout mice
Comparator
Wild-type controls
Outcome group
Stress hormones · Endocrine and hormones
Measurements
Corticosterone response to chronic stress
298%
OTKO mice
Corticosterone response to chronic stress
411%
controls
Source sentences
Summary
OTKO mice showed a reduced response to chronic stress (+298 versus+411%, OTKO mice versus controls, P < 0.005).
2 context sentences(design, population, supporting numbers)
Summary · context
We used oxytocin knockout (OTKO) mice to investigate the role of oxytocin in regulation of blood pressure, heart rate and stress reactivity (pressure reactivity and plasma corticosterone).
Summary · context
Male OTKO and control wild-type mice with carotid arterial catheters were exposed to intermittent shaker stress for 7 days (2 min stressors, 45 times per day).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1518435608

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

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