Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats.

Gao L, Yu LC

Regulatory peptides1 Aug 2004Cited by 51 (Europe PMC)

PMID15177920DOI10.1016/j.regpep.2004.02.011PepBankPUB-15177920

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, intracerebroventricular oxytocin dose-dependently increased hindpaw withdrawal latency to noxious thermal stimulation.
In plain wordsIn rats, oxytocin injected into the brain ventricles reduced pain responses to heat, with larger doses giving larger effects.
Peptide
Oxytocin
Outcome
IncreaseHindpaw withdrawal latency, thermal stimulation
Study
ratn: not reported in source
In vivo rat, intracerebroventricular
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
intracerebroventricular injection of oxytocin induced dose-dependent increases in hindpaw withdrawal latencies (HWL) to noxious thermal and mechanical stimulation in rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was performed to explore whether opioid system is involved in the oxytocin-induced antinociception in the brain of rats.
Report a problemFND-1517792001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, intracerebroventricular oxytocin dose-dependently increased hindpaw withdrawal latency to noxious mechanical stimulation.
In plain wordsIn rats, oxytocin injected into the brain ventricles reduced pain responses to pressure, with larger doses giving larger effects.
Peptide
Oxytocin
Outcome
IncreaseHindpaw withdrawal latency, mechanical stimulation
Study
ratn: not reported in source
In vivo rat, intracerebroventricular
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
intracerebroventricular injection of oxytocin induced dose-dependent increases in hindpaw withdrawal latencies (HWL) to noxious thermal and mechanical stimulation in rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was performed to explore whether opioid system is involved in the oxytocin-induced antinociception in the brain of rats.
Report a problemFND-1517792002
03AnimalAnimal study (in vivo)Mechanism
In rats, intracerebroventricular naloxone dose-dependently attenuated the antinociceptive effect of oxytocin, indicating opioid system involvement.
In plain wordsIn rats, the opioid blocker naloxone weakened the pain-relieving effect of oxytocin, which points to the opioid system.
Peptide
Oxytocin
Outcome
DecreaseOxytocin antinociception with naloxone
Study
ratn: not reported in source
In vivo rat, intracerebroventricular
Comparator
Naloxone
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
(2) The antinociceptive effect of oxytocin was attenuated dose-dependently by intracerebroventricular injection of naloxone, indicating an involvement of opioid system in the oxytocin-induced antinociception.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was performed to explore whether opioid system is involved in the oxytocin-induced antinociception in the brain of rats.
Report a problemFND-1517792003
04AnimalAnimal study (in vivo)Mechanism
In rats, the mu-opioid antagonist beta-funaltrexamine attenuated the antinociceptive effect of oxytocin.
In plain wordsIn rats, a blocker of the mu-opioid receptor weakened the pain-relieving effect of oxytocin.
Peptide
Oxytocin
Outcome
DecreaseOxytocin antinociception with mu-opioid antagonist beta-FNA
Study
ratn: not reported in source
In vivo rat, intracerebroventricular
Comparator
beta-funaltrexamine
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
(3) It is interesting that the antinociceptive effect of oxytocin was attenuated by subsequent intracerebroventricular injection of the mu-opioid antagonist beta-funaltrexamine (beta-FNA) and the kappa-opioid antagonist nor-binaltorphimine (nor-BNI), but not the delta-opioid antagonist naltrindole.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was performed to explore whether opioid system is involved in the oxytocin-induced antinociception in the brain of rats.
Report a problemFND-1517792004
05AnimalAnimal study (in vivo)Mechanism
In rats, the kappa-opioid antagonist nor-binaltorphimine attenuated the antinociceptive effect of oxytocin.
In plain wordsIn rats, a blocker of the kappa-opioid receptor weakened the pain-relieving effect of oxytocin.
Peptide
Oxytocin
Outcome
DecreaseOxytocin antinociception with kappa-opioid antagonist nor-BNI
Study
ratn: not reported in source
In vivo rat, intracerebroventricular
Comparator
nor-binaltorphimine
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
(3) It is interesting that the antinociceptive effect of oxytocin was attenuated by subsequent intracerebroventricular injection of the mu-opioid antagonist beta-funaltrexamine (beta-FNA) and the kappa-opioid antagonist nor-binaltorphimine (nor-BNI), but not the delta-opioid antagonist naltrindole.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was performed to explore whether opioid system is involved in the oxytocin-induced antinociception in the brain of rats.
Report a problemFND-1517792005
06AnimalAnimal study (in vivo)Mechanism
In rats, the delta-opioid antagonist naltrindole did not attenuate the antinociceptive effect of oxytocin.
In plain wordsIn rats, a blocker of the delta-opioid receptor did not weaken the pain-relieving effect of oxytocin.
Peptide
Oxytocin
Outcome
No significant changeOxytocin antinociception with delta-opioid antagonist naltrindole
Study
ratn: not reported in source
In vivo rat, intracerebroventricular
Comparator
Naltrindole
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
(3) It is interesting that the antinociceptive effect of oxytocin was attenuated by subsequent intracerebroventricular injection of the mu-opioid antagonist beta-funaltrexamine (beta-FNA) and the kappa-opioid antagonist nor-binaltorphimine (nor-BNI), but not the delta-opioid antagonist naltrindole.
1 context sentence(design, population, supporting numbers)
Summary · context
The present study was performed to explore whether opioid system is involved in the oxytocin-induced antinociception in the brain of rats.
Report a problemFND-1517792006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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