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Study · Animal study (in vivo) · rat · 2004

4 results

Melanocortin 4 receptor-mediated hyperphagia and activation of neuropeptide Y expression in the dorsomedial hypothalamus during lactation.

Chen P, Williams SM, Grove KL, Smith MS

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Jun 2004Cited by 49 (Europe PMC)

PMID15175378 (opens in a new tab)PMCIDPMC6729200 (opens in a new tab)DOI10.1523/jneurosci.0588-04.2004 (opens in a new tab)PepBankPUB-15175378
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In lactating rats, MTII injected into the dorsomedial hypothalamus significantly suppressed feeding induced by 24 h fasting.

    In plain wordsIn lactating rats, MTII injected into a brain region reduced eating after a 24-hour fast.

    Peptide
    Melanotan II
    Outcome
    DecreaseFeeding induced by 24 h fasting
    Study

    ratn: not reported in source

    Lactating rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · bilateral injection into the dorsomedial hypothalamusAs given in this study (rat).

    Source sentences

    Summary
    MTII injection significantly suppressed feeding induced by 24 hr fasting or suckling-induced hyperphagia.
    1 context sentence
    Summary · context
    To study the function of DMH MC4Rs in energy balance, an MC3/4R-selective agonist, melanotan II (MTII), was injected bilaterally into the DMH.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In lactating rats, MTII injected into the dorsomedial hypothalamus significantly suppressed suckling-induced hyperphagia.

    In plain wordsIn lactating rats, MTII injected into a brain region reduced the extra eating that suckling causes.

    Peptide
    Melanotan II
    Outcome
    DecreaseSuckling-induced hyperphagia
    Study

    ratn: not reported in source

    Lactating rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · bilateral injection into the dorsomedial hypothalamusAs given in this study (rat).

    Source sentences

    Summary
    MTII injection significantly suppressed feeding induced by 24 hr fasting or suckling-induced hyperphagia.
    1 context sentence
    Summary · context
    To study the function of DMH MC4Rs in energy balance, an MC3/4R-selective agonist, melanotan II (MTII), was injected bilaterally into the DMH.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In lactating rats, MTII greatly attenuated suckling-induced NPY expression in the dorsomedial hypothalamus.

    In plain wordsIn lactating rats, MTII strongly reduced the suckling-driven rise in NPY in a brain region that controls appetite.

    Peptide
    Melanotan II
    Outcome
    DecreaseSuckling-induced NPY expression in the dorsomedial hypothalamus
    Study

    ratn: not reported in source

    Lactating rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · bilateral injection into the dorsomedial hypothalamusAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, MTII treatment greatly attenuated suckling-induced NPY expression in the DMH.
    1 context sentence
    Summary · context
    To study the function of DMH MC4Rs in energy balance, an MC3/4R-selective agonist, melanotan II (MTII), was injected bilaterally into the DMH.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In suckling female rats, MTII stimulated uncoupling protein 1 activity in brown adipose tissue.

    In plain wordsIn suckling female rats, MTII raised uncoupling protein 1 activity in brown fat, a sign of more energy use.

    Peptide
    Melanotan II
    Outcome
    IncreaseUncoupling protein 1 activity in brown adipose tissue
    Study

    ratn: not reported in source

    Lactating rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · bilateral injection into the dorsomedial hypothalamusAs given in this study (rat).

    Source sentences

    Summary
    MTII treatment also stimulated uncoupling protein 1 activity in the brown adipose tissue of suckling female rats, indicative of increased sympathetic outflow.
    1 context sentence
    Summary · context
    To study the function of DMH MC4Rs in energy balance, an MC3/4R-selective agonist, melanotan II (MTII), was injected bilaterally into the DMH.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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