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Study · Ex vivo tissue · turkey · 2004

4 results

Receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide in turkey cerebral cortex: characterization by [125I]-VIP binding and effects on cyclic AMP synthesis.

Zawilska JB, Niewiadomski P, Nowak JZ

General and comparative endocrinology1 Jun 2004Cited by 7 (Europe PMC)

PMID15158130 (opens in a new tab)DOI10.1016/j.ygcen.2004.03.007 (opens in a new tab)PepBankPUB-15158130
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In turkey cerebral cortical membranes, [125I]-VIP bound a single class of high affinity sites with a Kd of 0.70 nM and a Bmax of 52 fmol/mg protein.

    In plain wordsIn lab tests on turkey brain membranes, labelled VIP bound one class of high affinity sites.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicable[125I]-VIP binding affinity and capacity
    Study

    turkeyn: not reported in source

    Turkey cerebral cortical membranes and slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Kd
    0.7 nM
    [125I]-VIP, turkey cortical membranes
    Bmax
    52 fmol/mg protein
    [125I]-VIP, turkey cortical membranes

    Source sentences

    Summary
    Saturation analysis resulted in a linear Scatchard plot, suggesting binding to a single class of high affinity receptor binding sites with a Kd of 0.70 nM and a Bmax of 52 fmol/mg protein.
  2. 02LabEx vivo tissueActivity measurement

    In turkey cerebral cortical membranes, mammalian VIP displaced [125I]-VIP binding with a potency similar to PACAP38, PACAP27 and chicken VIP, and much greater than PHI and secretin.

    In plain wordsIn lab tests on turkey brain membranes, mammalian VIP displaced labelled VIP about as well as PACAP, and far better than PHI or secretin.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicablePotency of mammalian VIP to displace [125I]-VIP binding
    Study

    turkeyn: not reported in source

    Turkey cerebral cortical membranes and slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The relative rank order of potency of the tested peptides to inhibit [125I]-VIP binding to turkey cerebrum was: PACAP38 approximately PACAP27 approximately chicken VIP approximately mammalian VIP >>> PHI >> secretin, chicken VIP16-28 (inactive).
  3. 03LabEx vivo tissueActivity measurement

    In turkey cerebral cortex, about 65% of specific [125I]-VIP binding sites were sensitive to the GTP analogue Gpp(NH)p.

    In plain wordsIn lab tests on turkey brain tissue, about 65% of the labelled VIP binding sites were sensitive to a GTP analogue.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableGpp(NH)p-sensitive fraction of [125I]-VIP binding sites
    Study

    turkeyn: not reported in source

    Turkey cerebral cortical membranes and slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Gpp(NH)p-sensitive binding sites
    65%
    [125I]-VIP, turkey cerebral cortex

    Source sentences

    Summary
    About 65% of specific [125I]-VIP binding sites in turkey cerebral cortex was sensitive to Gpp(NH)p, a nonhydrolysable analogue of GTP.
  4. 04LabEx vivo tissueActivity measurement

    In turkey cerebral cortical slices, mammalian VIP stimulated cyclic AMP formation in a concentration-dependent manner, with an EC50 of 202 nM.

    In plain wordsIn lab tests on turkey brain slices, mammalian VIP raised cyclic AMP, less strongly than PACAP or chicken VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseCyclic AMP formation stimulated by mammalian VIP
    Study

    turkeyn: not reported in source

    Turkey cerebral cortical membranes and slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    EC50
    202 nM
    mammalian VIP, cyclic AMP formation, turkey cerebral cortical slices

    Source sentences

    Summary
    PACAP38, PACAP27, chicken VIP and, to a lesser extent, mammalian VIP potently stimulated cyclic AMP formation in turkey cerebral cortical slices in a concentration-dependent manner, displaying EC50 values of 8.7 nM (PACAP38), 21.3 nM (PACAP27), 67.4 nM (chicken VIP), and 202 nM (mammalian VIP).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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