Maintenance of increased bone mass after recombinant human parathyroid hormone (1-84) with sequential zoledronate treatment in ovariectomized rats.

Rhee Y, Won YY, Baek MH, Lim SK

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research19 Jan 2004Cited by 18 (Europe PMC)

PMID15125792DOI10.1359/jbmr.040123PepBankPUB-15125792

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, femoral BMD was significantly higher with PTH maintenance than in untreated OVX rats (p < 0.05).
In plain wordsIn ovariectomized rats, PTH maintenance produced higher femoral bone density than no treatment.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseFemoral BMD versus untreated OVX
Study
ratn = 12
Ovariectomized Sprague-Dawley rats
Comparator
OVX
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 microg/kg/day, 5 days/weekAs given in this study (rat).
Source sentences
Summary
Bone quantity data showed that the BMD and most of the microstructural parameters were significantly higher in the PTH-M and PTH-Z groups than in the OVX and PTH-W groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
(1) ovariectomized rats (OVX; n = 6), (2) sham-operated rats (SHAM; n = 6), (3) OVX rats with PTH maintenance (PTH-M; n = 6), (4) OVX rats treated with PTH and then PTH was withdrawn (PTH-W; n = 6),
Summary · context
BMD of the right femora was measured by DXA. microCT was used to measure the structural parameters of the second lumbar vertebrae.
Report a problemFND-1512579201
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, femoral BMD was significantly higher with PTH maintenance than after PTH withdrawal (p < 0.05).
In plain wordsIn ovariectomized rats, bone density was higher with PTH maintenance than after PTH withdrawal.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseFemoral BMD versus PTH withdrawal
Study
ratn = 12
Ovariectomized Sprague-Dawley rats
Comparator
PTH-W
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 microg/kg/day, 5 days/weekAs given in this study (rat).
Source sentences
Summary
Bone quantity data showed that the BMD and most of the microstructural parameters were significantly higher in the PTH-M and PTH-Z groups than in the OVX and PTH-W groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
(1) ovariectomized rats (OVX; n = 6), (2) sham-operated rats (SHAM; n = 6), (3) OVX rats with PTH maintenance (PTH-M; n = 6), (4) OVX rats treated with PTH and then PTH was withdrawn (PTH-W; n = 6),
Summary · context
BMD of the right femora was measured by DXA. microCT was used to measure the structural parameters of the second lumbar vertebrae.
Report a problemFND-1512579202
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, most vertebral microstructural parameters were significantly higher with PTH maintenance than in untreated OVX rats (p < 0.05).
In plain wordsIn ovariectomized rats, most bone microstructural parameters were higher with PTH maintenance than no treatment.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseVertebral microstructural parameters versus untreated OVX
Study
ratn = 12
Ovariectomized Sprague-Dawley rats
Comparator
OVX
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 microg/kg/day, 5 days/weekAs given in this study (rat).
Source sentences
Summary
Bone quantity data showed that the BMD and most of the microstructural parameters were significantly higher in the PTH-M and PTH-Z groups than in the OVX and PTH-W groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
(1) ovariectomized rats (OVX; n = 6), (2) sham-operated rats (SHAM; n = 6), (3) OVX rats with PTH maintenance (PTH-M; n = 6), (4) OVX rats treated with PTH and then PTH was withdrawn (PTH-W; n = 6),
Summary · context
BMD of the right femora was measured by DXA. microCT was used to measure the structural parameters of the second lumbar vertebrae.
Report a problemFND-1512579203
04AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, most vertebral microstructural parameters were significantly higher with PTH maintenance than after PTH withdrawal (p < 0.05).
In plain wordsIn ovariectomized rats, most bone microstructural parameters were higher with PTH maintenance than after withdrawal.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseVertebral microstructural parameters versus PTH withdrawal
Study
ratn = 12
Ovariectomized Sprague-Dawley rats
Comparator
PTH-W
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 microg/kg/day, 5 days/weekAs given in this study (rat).
Source sentences
Summary
Bone quantity data showed that the BMD and most of the microstructural parameters were significantly higher in the PTH-M and PTH-Z groups than in the OVX and PTH-W groups (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
(1) ovariectomized rats (OVX; n = 6), (2) sham-operated rats (SHAM; n = 6), (3) OVX rats with PTH maintenance (PTH-M; n = 6), (4) OVX rats treated with PTH and then PTH was withdrawn (PTH-W; n = 6),
Summary · context
BMD of the right femora was measured by DXA. microCT was used to measure the structural parameters of the second lumbar vertebrae.
Report a problemFND-1512579204
05AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, femoral midshaft ultimate force with PTH maintenance exceeded that in untreated OVX rats (p < 0.05).
In plain wordsIn ovariectomized rats, femoral strength was higher with PTH maintenance than no treatment.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseFemoral ultimate force versus untreated OVX
Study
ratn = 12
Ovariectomized Sprague-Dawley rats
Comparator
OVX
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 microg/kg/day, 5 days/weekAs given in this study (rat).
Source sentences
Summary
The ultimate force (Fu) at the midshaft of the femora was similar in the treated groups and stronger than in the OVX group (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
(1) ovariectomized rats (OVX; n = 6), (2) sham-operated rats (SHAM; n = 6), (3) OVX rats with PTH maintenance (PTH-M; n = 6), (4) OVX rats treated with PTH and then PTH was withdrawn (PTH-W; n = 6),
Summary · context
Three-point bending test of the femora and compressive tests of vertebrae were also performed.
Report a problemFND-1512579206
06AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, vertebral ultimate force was significantly higher with PTH maintenance than in untreated OVX rats; reported increases spanned approximately 44-47% across comparisons.
In plain wordsIn ovariectomized rats, vertebral strength was higher with PTH maintenance than no treatment.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseVertebral ultimate force versus untreated OVX
Study
ratn = 12
Ovariectomized Sprague-Dawley rats
Comparator
OVX
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 microg/kg/day, 5 days/weekAs given in this study (rat).
Source sentences
Summary
However, in the vertebrae, the Fu of the PTH-M and PTH-Z groups was significantly higher, by approximately 44-47%, than in the OVX and PTH-E groups and showed a higher tendency than in the PTH-W group.
2 context sentences(design, population, supporting numbers)
Summary · context
(1) ovariectomized rats (OVX; n = 6), (2) sham-operated rats (SHAM; n = 6), (3) OVX rats with PTH maintenance (PTH-M; n = 6), (4) OVX rats treated with PTH and then PTH was withdrawn (PTH-W; n = 6),
Summary · context
Three-point bending test of the femora and compressive tests of vertebrae were also performed.
Report a problemFND-1512579207
07AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, vertebral ultimate force tended to be higher with PTH maintenance than after withdrawal.
In plain wordsIn ovariectomized rats, vertebral strength tended to be higher with PTH maintenance than after withdrawal.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseVertebral ultimate force versus PTH withdrawal
Study
ratn = 12
Ovariectomized Sprague-Dawley rats
Comparator
PTH-W
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 microg/kg/day, 5 days/weekAs given in this study (rat).
Source sentences
Summary
However, in the vertebrae, the Fu of the PTH-M and PTH-Z groups was significantly higher, by approximately 44-47%, than in the OVX and PTH-E groups and showed a higher tendency than in the PTH-W group.
2 context sentences(design, population, supporting numbers)
Summary · context
(1) ovariectomized rats (OVX; n = 6), (2) sham-operated rats (SHAM; n = 6), (3) OVX rats with PTH maintenance (PTH-M; n = 6), (4) OVX rats treated with PTH and then PTH was withdrawn (PTH-W; n = 6),
Summary · context
Three-point bending test of the femora and compressive tests of vertebrae were also performed.
Report a problemFND-1512579208
08AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, only the PTH-maintenance group showed significantly increased cortical thickness (p = 0.001).
In plain wordsIn ovariectomized rats, only PTH maintenance significantly increased cortical thickness.
Peptide
PTH 1-84 (parathyroid hormone)
Outcome
IncreaseCortical thickness
Study
ratn: not reported in source
Ovariectomized Sprague-Dawley rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 microg/kg/day, 5 days/weekAs given in this study (rat).
Source sentences
Summary
Measurement of the cortical thickness revealed that only the PTH-M group showed a significant increase (p = 0.001).
3 context sentences(design, population, supporting numbers)
Summary · context
Thirty-six, 20-week-old Sprague-Dawley rats were used.
Summary · context
BMD of the right femora was measured by DXA. microCT was used to measure the structural parameters of the second lumbar vertebrae.
Summary · context
Three-point bending test of the femora and compressive tests of vertebrae were also performed.
Report a problemFND-1512579205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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