In adult rats with facial nerve avulsion, MGF cDNA injected into facial muscle gave 37% neuroprotection of motoneurons compared with control plasmid and avulsion-only groups, reading the abstract's 'respectively' order at face value (a later sentence calls MGF more effective than IGF-IEa).
In plain wordsIn rats with facial nerve injury, MGF gene delivery protected some nerve cells compared with control groups.
- Peptide
- MGF / PEG-MGF
- Outcome
- IncreaseMotoneuron survival after MGF cDNA injection
- Study
ratn: not reported in source
- Comparator
- Control plasmid and avulsion-only groups
- Outcome group
- Neuroprotection · Nervous system and cognition
Measurements
- Motoneuron neuroprotection
- 37%
- MGF cDNA
Source sentences
This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups.
1 context sentence(design, population, supporting numbers)
We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.