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Study · Not a test of the peptide alone · 2004

4 results

Estrogen receptor-beta in oxytocin and vasopressin neurons of the rat and human hypothalamus: Immunocytochemical and in situ hybridization studies.

Hrabovszky E, Kalló I, Steinhauser A, Merchenthaler I, Coen CW, Petersen SL, Liposits Z

The Journal of comparative neurology1 May 2004Cited by 91 (Europe PMC)

PMID15116394 (opens in a new tab)DOI10.1002/cne.20127 (opens in a new tab)PepBankPUB-15116394
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneObservational studyMechanism

    In human autopsy samples, subsets of oxytocin and vasopressin neurons expressed estrogen receptor-beta.

    In plain wordsIn human brain tissue after death, some oxytocin cells carried the estrogen receptor-beta.

    Peptide
    Oxytocin
    Outcome
    Not applicableER-beta expression in human oxytocin neurons
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Finally, double-label immunocytochemical analysis of human autopsy samples showed that subsets of OT and VP neurons also express ER-beta in the human.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, 45-98% of oxytocin neurons in distinct subregions of the paraventricular and supraoptic nuclei showed estrogen receptor-beta immunoreactivity.

    In plain wordsIn rats, many oxytocin-producing brain cells carried the estrogen receptor-beta, in a share that depended on the brain region.

    Peptide
    Oxytocin
    Outcome
    Not applicableER-beta immunoreactivity in oxytocin neurons
    Study

    ratn: not reported in source

    Ovariectomized rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Measurements

    OT neurons with ER-beta immunoreactivity
    45 to 98%
    distinct subregions of PVH and SO

    Source sentences

    Summary
    In distinct subregions, 45-98% of OT neurons and 88-99% of VP neurons exhibited ER-beta immunoreactivity that was confined to cell nuclei.
    1 context sentence
    Summary · context
    Topographical distribution of estrogen receptor-beta (ER-beta)-synthesizing oxytocin (OT) and vasopressin (VP) neurons was studied in the hypothalamic paraventricular and supraoptic nuclei (PVH; SO) of ovariectomized rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, magnocellular oxytocin neurons contained low ER-beta signal, whereas oxytocin cells in the ventral medial parvicellular subnucleus and caudal PVH showed robust receptor labeling.

    In plain wordsIn rats, estrogen receptor-beta labeling was weak in large oxytocin cells and strong in some smaller oxytocin cell groups.

    Peptide
    Oxytocin
    Outcome
    MixedER-beta signal intensity by oxytocin neuron subtype
    Study

    ratn: not reported in source

    Ovariectomized rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Magnocellular OT neurons in the PVH, SO, and accessory cell groups typically contained low levels of the ER-beta signal; in contrast, robust receptor labeling was displayed by OT cells in the ventral subdivision of medial parvicellular subnucleus and in the caudal PVH (dorsal subdivision of medial p…
    1 context sentence
    Summary · context
    Topographical distribution of estrogen receptor-beta (ER-beta)-synthesizing oxytocin (OT) and vasopressin (VP) neurons was studied in the hypothalamic paraventricular and supraoptic nuclei (PVH; SO) of ovariectomized rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, ER-beta signal was generally more intense and present in higher proportions of vasopressin neurons than of oxytocin neurons of similar topography.

    In plain wordsIn rats, estrogen receptor-beta labeling was usually stronger in vasopressin cells than in oxytocin cells.

    Peptide
    Oxytocin
    Outcome
    Not applicableER-beta signal in vasopressin versus oxytocin neurons
    Study

    ratn: not reported in source

    Ovariectomized rats
    Comparator
    Vasopressin neurons
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Estrogen receptor-beta signal was generally more intense and present in higher proportions of magnocellular and parvicellular VP vs. OT neurons of similar topography.
    1 context sentence
    Summary · context
    Topographical distribution of estrogen receptor-beta (ER-beta)-synthesizing oxytocin (OT) and vasopressin (VP) neurons was studied in the hypothalamic paraventricular and supraoptic nuclei (PVH; SO) of ovariectomized rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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