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Study · In vitro (cells) · 2004

4 results

Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people.

Lezhava T, Khavison V, Monaselidze J, Jokhadze T, Dvalishvili N, Bablishvili N, Barbakadze S

Biogerontology1 Jan 2004Cited by 5 (Europe PMC)

PMID15105581 (opens in a new tab)DOI10.1023/b:bgen.0000025070.90330.7f (opens in a new tab)PepBankPUB-15105581
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured lymphocytes from old people, Vilon induced deheterochromatinization of total heterochromatin.

    In plain wordsIn cells, Vilon loosened total heterochromatin in cultured human lymphocytes.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseTotal heterochromatin deheterochromatinization
    Study

    humann: not reported in source

    Cultured lymphocytes from old people
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The data obtained indicate that Vilon (a) induces unrolling (deheterochromatinization) of total heterochromatin;
    1 context sentence
    Summary · context
    The effect of the synthetic peptide bioregulator Vilon on structural and facultative heterochromatin of cultured lymphocytes from old people has been studied.
  2. 02LabIn vitro (cells)Mechanism

    In cultured lymphocytes from old people, Vilon activated synthetic processes through ribosomal gene reactivation and nucleolus organizer deheterochromatinization.

    In plain wordsIn cells, Vilon activated synthesis processes through ribosomal gene reactivation in cultured human lymphocytes.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseSynthetic processes through ribosomal gene reactivation
    Study

    humann: not reported in source

    Cultured lymphocytes from old people
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (b) activates synthetic processes caused by the reactivation of ribosomal genes as a result of deheterochromatinization of nucleolus organizer regions;
    1 context sentence
    Summary · context
    The effect of the synthetic peptide bioregulator Vilon on structural and facultative heterochromatin of cultured lymphocytes from old people has been studied.
  3. 03LabIn vitro (cells)Mechanism

    In cultured lymphocytes from old people, Vilon released genes repressed by euchromatin condensation into facultative heterochromatin.

    In plain wordsIn cells, Vilon released genes repressed by chromatin condensation in cultured human lymphocytes.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseRelease of repressed genes in facultative heterochromatin
    Study

    humann: not reported in source

    Cultured lymphocytes from old people
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (c) releases the genes repressed due to the condensation of euchromatic regions forming facultative heterochromatin;
    1 context sentence
    Summary · context
    The effect of the synthetic peptide bioregulator Vilon on structural and facultative heterochromatin of cultured lymphocytes from old people has been studied.
  4. 04LabIn vitro (cells)Mechanism

    In cultured lymphocytes from old people, Vilon did not induce pericentromeric structural heterochromatin decondensation.

    In plain wordsIn cells, Vilon did not loosen pericentromeric structural heterochromatin in cultured human lymphocytes.

    Peptide
    Vilon (KE)
    Outcome
    No significant changePericentromeric structural heterochromatin decondensation
    Study

    humann: not reported in source

    Cultured lymphocytes from old people
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (d) does not induce decondensation of pericentromeric structural heterochromatin.
    1 context sentence
    Summary · context
    The effect of the synthetic peptide bioregulator Vilon on structural and facultative heterochromatin of cultured lymphocytes from old people has been studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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