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Study · In vitro (cells) · hamster · 2004

4 results

alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells.

Elliott RJ, Szabo M, Wagner MJ, Kemp EH, MacNeil S, Haycock JW

The Journal of investigative dermatology1 Apr 2004Cited by 41 (Europe PMC)

PMID15102092 (opens in a new tab)DOI10.1111/j.0022-202x.2004.22404.x (opens in a new tab)PepBankPUB-15102092
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    KPV did not raise cyclic AMP in HaCaT or normal human keratinocytes.

    In plain wordsIn cells, KPV did not raise cyclic AMP in human skin cells.

    Peptide
    KPV
    Outcome
    No significant changeCyclic AMP in keratinocytes
    Study

    humann: not reported in source

    HaCaT and normal human keratinocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No elevation in cyclic AMP was detected in either HaCaT or normal human keratinocytes in response to alpha-MSH, KPV or ACTH peptides.
    1 context sentence
    Summary · context
    The aim of this study was to examine the intracellular signalling of key MSH and ACTH peptides in human keratinotocytes.
  2. 02LabIn vitro (cells)Mechanism

    KPV (10(-15) to 10(-7) M) caused rapid, acute intracellular calcium rises in HaCaT keratinocytes, but only with the adenosine agonist PIA present.

    In plain wordsIn cells, KPV raised calcium inside a human skin cell line, but only when a second compound that blocks the cyclic AMP pathway was present.

    Peptide
    KPV
    Outcome
    IncreaseIntracellular calcium in HaCaT keratinocytes
    Study

    humann: not reported in source

    HaCaT keratinocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Rapid and acute intracellular calcium, however, were observed in HaCaT keratinocytes in response to alpha-MSH (10(-15)-10(-7) M), KPV (10(-15)-10(-7) M), KP-D-V (10(-15)-10(-7) M) and ACTH (10(-15)-10(-7) M), but only in the presence of PIA, an adenosine agonist that inhibits the cyclic AMP pathway.
    1 context sentence
    Summary · context
    The aim of this study was to examine the intracellular signalling of key MSH and ACTH peptides in human keratinotocytes.
  3. 03LabIn vitro (cells)Mechanism

    Normal human keratinocytes showed a calcium response to KPV and the other peptides tested, as HaCaT cells did.

    In plain wordsIn cells, normal human skin cells showed a calcium response to KPV.

    Peptide
    KPV
    Outcome
    IncreaseIntracellular calcium in normal keratinocytes
    Study

    humann: not reported in source

    normal human keratinocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Normal keratinocytes responded to all the above peptides
    2 context sentences
    Summary · context
    Rapid and acute intracellular calcium, however, were observed in HaCaT keratinocytes in response to alpha-MSH (10(-15)-10(-7) M), KPV (10(-15)-10(-7) M), KP-D-V (10(-15)-10(-7) M) and ACTH (10(-15)-10(-7) M), but only in the presence of PIA, an adenosine agonist that inhibits the cyclic AMP pathway.
    Summary · context
    The aim of this study was to examine the intracellular signalling of key MSH and ACTH peptides in human keratinotocytes.
  4. 04LabIn vitro (cells)Mechanism

    In Chinese hamster ovary cells transfected with the MC-1 receptor, KPV raised intracellular calcium.

    In plain wordsIn cells, KPV raised calcium inside hamster cells that carried the MC-1 receptor.

    Peptide
    KPV
    Outcome
    IncreaseIntracellular calcium in MC-1R-transfected CHO cells
    Study

    hamstern: not reported in source

    CHO cells stably transfected with MC-1 receptor
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Stable transfection of Chinese hamster ovary cells with the MC-1 receptor showed that alpha-MSH and the KPV peptides elevated intracellular calcium.
    1 context sentence
    Summary · context
    The aim of this study was to examine the intracellular signalling of key MSH and ACTH peptides in human keratinotocytes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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